AccScience Publishing / TD / Online First / DOI: 10.36922/TD025310074
PERSPECTIVE ARTICLE

Large language models in oncodermatology

Mansak Shishak1 Sorun Shishak2* Sameer Rastogi3
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1 Department of Dermatology, Fortis Hospital and Research Center, New Delhi, India
2 Department of Radiation Oncology, Medanta Hospital, Gurugram, Haryana, India
3 Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
Tumor Discovery, 025310074 https://doi.org/10.36922/TD025310074
Received: 31 July 2025 | Revised: 23 September 2025 | Accepted: 11 October 2025 | Published online: 4 November 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

With the release of ChatGPT, a generative artificial intelligence-based chatbot, the potential for multiple applications in medicine seems not just plausible but inevitably intertwined with oncology science. Their rapid fine-tuning and evolution into updated versions that incorporate different modes—gradually enhancing “reasoning” and contextual abilities—offer promise in bridging critical gaps in healthcare delivery. In the evolving landscape of precision oncology and dermatology, the skin has long served as both a mirror and a messenger, revealing malignancies through primary lesions, paraneoplastic signs, metastases, or therapy-related adverse effects. Large language models, deep learning systems trained on vast corpora that include open-source biomedical data, are poised to redefine how we process, contextualize, and act upon complex, language-rich, and algorithm-rich clinical datasets.

Keywords
Large language models
Artificial intelligence
ChatGPT
Oncology
Oncodermatology
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
References
  1. Liu F, Zhou H, Gu B, et al. Application of large language models in medicine. Nat Rev Bioeng. 2025;3:445-464. doi: 10.1038/s44222-025-00279-5

 

  1. Singhal K, Azizi S, Tu T, et al. Large language models encode clinical knowledge. Nature. 2023;620:172-180. doi: 10.1038/s41586-023-06291-3

 

  1. Lane R, Hay A, Schwarz A, Berry DM, Shrager J. Eliza Reanimated: The World’s First Chatbot Restored On The World’s First-Time Sharing System. arXiv. 2025. Available from: https://arxiv.org/abs/2501.06707 [Last accessed on 2025 Oct 21]. doi: 10.48550/arXiv.2501

 

  1. Roster K, Kann RB, Farabi B, Gronbeck C, Brownstone N, Lipner SR. Readability and health literacy scores for ChatGPT-generated dermatology public education materials: Cross-sectional analysis of sunscreen and melanoma questions. JMIR Dermatol. 2024;7:e50163. doi: 10.2196/50163

 

  1. Bender EM, Gebru T, McMillan-Major A, Shmitchell S. On the dangers of stochastic parrots: Can language models be too big? In: Proceedings of the 2021 ACM Conference on Fairness, Accountability, and Transparency (FAccT ’21). New York, NY: Association for Computing Machinery; 2021. p. 610-623. doi: 10.1145/3442188.3445922

 

  1. Veccio C, Barley S, Kennedy LB, et al. Analysis of a large language model-based system versus manual review in clinical data abstraction and deduction from real-world medical records of patients with melanoma for clinical trial eligibility assessment. J Clin Oncol. 2025;43:1571. doi: 10.1200/JCO.2025.43.16_suppl.1571

 

  1. Hom J, Nikowitz J, Ottesen R, Niland JC. Facilitating clinical research through automation: Combining optical character recognition with natural language processing. Clin Trials. 2022;19(5):504-511. doi: 10.1177/17407745221093621

 

  1. Kabak Y, Erturkmen F, Gokce B, et al. FHIR-RAG-MEDS: Integrating HL7 FHIR with Retrieval-Augmented Large Language Models for Enhanced Medical Decision Support. [arXiv Preprint]; 2025. doi: 10.48550/arXiv.2509.07706

 

  1. Carl N, Schramm F, Haggenmüller S, et al. Large language model use in clinical oncology. NPJ Precis Oncol. 2024;8:240. doi: 10.1038/s41698-024-00733-4

 

  1. Chen D, Parsa R, Swanson K, et al. Large language models in oncology: A review. BMJ Oncol. 2025;4(1):e000759. doi: 10.1136/bmjonc-2025-000759

 

  1. Wei L, Niraula D, Gates EDH, et al. Artificial intelligence (AI) and machine learning (ML) in precision oncology: A review on enhancing discoverability through multiomics integration. Br J Radiol. 2023;96:20230211. doi: 10.1259/bjr.20230211

 

  1. Gilbert S, Kather JN, Hogan A. Augmented non-hallucinating large language models as medical information curators. NPJ Digit Med. 2024;7:100. doi: 10.1038/s41746-024-01081-0

 

  1. Crowe B, Rodriguez JA. Identifying and addressing bias in artificial intelligence. JAMA Netw Open. 2024; 7(8):e2425955. doi: 10.1001/jamanetworkopen.2024.25955
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Tumor Discovery, Electronic ISSN: 2810-9775 Print ISSN: 3060-8597, Published by AccScience Publishing