Mucosal Schwann cell hamartoma of the gastrointestinal tract: A benign and little-known entity
Mucosal Schwann cell hamartoma (MSCH) is a rare neurogenic tumor occurring in the gastrointestinal tract composed of Schwann cell components. To investigate the clinical and histopathological features, immunohistochemical characteristics, diagnosis, and differential diagnosis of MSCH, we reviewed the gastrointestinal endoscopic biopsy cases in the past 3 years. Along with a re-examination of the histological patterns, immunohistochemical tests were performed to identify cases that met the diagnostic criteria for MSCH. The endoscopic and clinical data of the patients were collected. We found that MSCH is a clinically rare benign lesion of neurogenic origin of the gastrointestinal tract with non-specific clinical and endoscopic manifestations and is not associated with hereditary cancer syndromes. Therefore, the integration of morphological and immunohistochemical findings is crucial for making accurate diagnosis of this disease, which is essential to avoid unnecessary treatment.
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