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REVIEW ARTICLE

Boronosteroids as potential antitumor drugs: A review

Valery M. Dembitsky1,2* ,  Alexander O. Terent’ev2 ,  Sergey V. Baranin2
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1 Bio-Pharm Laboratories, Lake Forest, California, United States of America
2 Department of Carbocyclic Compounds, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
Tumor Discovery, 025290069 https://doi.org/10.36922/TD025290069
Received: 11 July 2025 | Revised: 21 September 2025 | Accepted: 14 October 2025 | Published online: 3 November 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Boron’s unique chemical properties have long fascinated scientists, particularly its ability to form stable five- or six-membered spiroborate compounds. Among these, tetracoordinate compounds, where boron is bonded to four oxygen atoms, stand out for their versatility and significance across various fields. Over the past few decades, these compounds have demonstrated remarkable pharmacological properties and biological activity, establishing them as a cornerstone of modern boron chemistry. The reaction between boric acid and cis-1,2- and 1,3-diol groups has been known for more than a century, providing the basis for analytical chemistry and adsorption techniques. Building upon this knowledge, the interaction between boric acid and steroids opens new horizons in lipid chemistry. These boron-steroid complexes, though largely unexplored, hold great promise for future biomedical applications. The steroids that form boron complexes exhibit enhanced solubility in an aqueous solution, which in turn augments the antitumor efficacy of these steroids. The data presented show that 58% of steroids exhibit strong antineoplastic and related activities, 31% display moderate activity, and <11% show weak antineoplastic activity and varying levels of activity in other biological mechanisms.

Keywords
Antitumor activity
Boronosteroids
Bacteria
Invertebrates
Fungi
Plants
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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Tumor Discovery, Electronic ISSN: 2810-9775 Print ISSN: 3060-8597, Published by AccScience Publishing
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