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ORIGINAL RESEARCH ARTICLE
Prevalence and clinical significance of rs9929218 in Cadherin 1 and rs6983267 in the 8q24 region among Kurdish colorectal cancer patients in Iraq
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1 Department of Dentistry, College of Medicine, Komar University of Science and Technology, Chaq-Chaq-Qualaraisi, Sulaimani,
Iraq
Tumor Discovery, 025110021 https://doi.org/10.36922/TD025110021
Received: 14 March 2025 | Revised: 19 May 2025 | Accepted: 20 May 2025 | Published online: 4 June 2025
(This article belongs to the Special Issue Colorectal Cancer: Best Tools for Diagnosis to Management Strategies)
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide, with genetic factors playing a significant role in its pathogenesis. This study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) – rs9929218 in the Cadherin 1 (CDH1) gene and rs6983267 in the 8q24 region – among Kurdish CRC patients in Sulaymaniyah, Iraq, and assessed their association with clinicopathological features. Blood samples from 290 CRC patients and 100 healthy controls were analyzed using allele-specific polymerase chain reaction. The frequency of rs9929218 was 20.34% in CRC patients compared to 7% in controls, while rs6983267 was detected in 26.55% of CRC cases versus 11% of controls. Both SNPs were significantly associated with CRC risk in univariate analyses; however, after adjusting for age, sex, tumor grade, and TNM stage in multivariate logistic regression, neither SNP remained an independent risk factor. Nonetheless, both SNPs showed significant associations with advanced tumor stage, nodal involvement, and perineural invasion, suggesting a potential role in disease progression rather than initiation. These findings enhance the understanding of CRC genetics in the Kurdish population and highlight the need for larger, functionally validated studies to confirm these associations.
Keywords
Colorectal cancer
Genetic polymorphism
CDH1 gene
8q24 region
Cancer susceptibility
Kurdish population
Funding
None.
Conflict of interest
The author declares no conflicts of interest.
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