N6-methyladenosine-related long noncoding RNA is a potential biomarker for predicting pancreatic cancer prognosis

¹ Anhui Medical University, Clinical College of Peking University Shenzhen Hospital, Fifth Clinical Medical College of Anhui Medical University, China

² Peking University Shenzhen Hospital Clinical School, Futian District, Shenzhen, Guangdong Province, China

Tumor Discovery 2022, 1(2), 165 https://doi.org/10.36922/td.v1i2.165

Submitted: 4 August 2022 | Accepted: 23 September 2022 | Published: 11 October 2022

© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Pancreatic cancer is a common malignant tumor of the digestive system, with insidious onset, difficult early diagnosis, easy metastasis, and poor prognosis. N6-methyladenosine (m6A) and long non-coding RNA (lncRNA) play important roles in the prognostic value and immunotherapy response of pancreatic adenocarcinoma (PAAD). Therefore, it is crucial to recognize m6A-related-lncRNAs in PAAD patients. In this study, m6A-related lncRNAs were obtained by coexpression analysis. Univariate, the Least Absolute Shrinkage, and Selection Operator (LASSO) and multivariate Cox regression analyses were performed to construct m6A-related lncRNA prognostic models. Kaplan–Meier analysis, principal component analysis, feature-rich annotation, and nomogram were used to analyze the accuracy of risk models. Potential drugs targeting this model are also discussed. A prognostic model based on m6A-related lncRNAs was constructed, potential drugs targeting this m6A-related lncRNAs feature were discovered, and the relationship with immunotherapy response was studied. Finally, a nomogram was established to predict survival in PAAD patients. This m6A-based lncRNAs risk prognostic model may be promising for clinical prediction of prognosis and immunotherapy response in PAAD patients.

Keywords

Bioinformatics

N6-methyladenosine

Long non-coding RNA

Pancreatic adenocarcinoma

Funding

No external funding was received for this work.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that they have no conflicts of interest.

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