Orthopedic infection remains a critical challenge across species, directly compromising implant stability and fracture healing. While human orthopedic surgery is performed within highly controlled and technologically advanced environments, large-animal veterinary orthopedics routinely operates under conditions of elevated contamination, mechanical overload, and limited environmental control. This contrast transforms veterinary surgery into a natural stress test for infection-prevention strategies, exposing vulnerabilities that may remain concealed in optimized human operating rooms. Conversely, human orthopedics continues to drive innovations in implant surface engineering, local antimicrobial delivery, predictive modeling, and personalized prophylaxis that hold significant translational potential for veterinary practice. This perspective explores the lessons from bidirectional exchange between human and veterinary orthopedic surgery, emphasizing how comparative analysis of infection control, implant performance, and surgical environments can inform more resilient and context-adaptable strategies. By fostering intentional collaboration across disciplines, comparative orthopedics may emerge as a translational framework capable of advancing infection prevention and implant reliability in both human and veterinary medicine.