Vertigo or dizziness as the first presentation of epilepsy: A case report

Vertigo or dizziness is a common neurological symptom, but it is rarely regarded as the first presenting symptom of epilepsy. Patients who present with vertigo as the first symptom of epilepsy may be misdiagnosed or missed diagnose. We report a case presenting with vertigo or dizziness as the first manifestation of epilepsy and review relevant literature. A 71-year-old female patient sought medical attention in view of paroxysmal dizziness for a year that progressively worsened over the course of 1 week. Initially, her dizziness occurred 2 or 3 times a month, lasting for less than a minute each time. However, her attacks became more frequent and severe over the course of 1 week. Twenty-four-hour electroencephalogram (EEG) monitoring showed spike-and-slow-wave complex discharges at both sphenoidal electrodes, with the left being more prominent. The patient was treated with oral valproic acid. After a 9-month follow-up, the frequency of dizziness was markedly reduced. Although the pathogenesis of epileptic vertigo remains ambiguous, the current literature indicates that vestibular cortical neurons may be closely associated with periodic abnormal discharge of the brain lobe. Based on comprehensive medical history and EEG results, we should exercise caution when diagnosing this kind of epilepsy.
Kim DW, Sunwoo JS, Lee SK, 2016, Incidence and localizing value of vertigo and dizziness in patients with epilepsy: Video-EEG monitoring study. Epilepsy Res, 126: 102–105. https://doi.org/10.1016/j.eplepsyres.2016.07.002
Hewett R, Bartolomei F, 2013, Epilepsy and the cortical vestibular system: tales of dizziness and recent concepts. Front Integr Neurosci, 7: 73. https://doi.org/10.3389/fnint.2013.00073
Tarnutzer AA, Lee SH, Robinson KA, Kaplan PW, et al., 2015, Clinical and electrographic findings in epileptic vertigo and dizziness: A systematic review. Neurology, 84: 1595–604. https://doi.org/10.1212/WNL.0000000000001474
Bisdorff AR, Staab JP, Newman-Toker DE, 2015, Overview of the international classification of vestibular disorders. Neurol Clin, 33: 541–550. https://doi.org/10.1016/j.ncl.2015.04.010
Strupp M, Lopez-Escamez JA, Kim JS, et al., 2016, Vestibular paroxysmia: Diagnostic criteria. J Vestib Res, 26: 409–415. https://doi.org/10.3233/VES-160589
Bladin PF, 1998, History of “epileptic vertigo”: Its medical, social, and forensic problems. Epilepsia, 39: 442–447. https://doi.org/10.1111/j.1528-1157.1998.tb01398.x
Batu ED, Anlar B, Topçu M, et al., 2015, Vertigo in childhood: A retrospective series of 100 children. Eur J Paediatr Neurol, 19: 226–232. https://doi.org/10.1016/j.ejpn.2014.12.009
Jiang Y, Zhou X, 2020, Frontal lobe epilepsy manifesting as vertigo: A case report and literature review. J Int Med Res, 48: 300060520946166. https://doi.org/10.1177/0300060520946166
Surmeli R, Yalcin AD, Surmeli M, et al., 2020, Vertiginous epilepsy: Documentation of clinical and electrophysiological findings of nine patients. Epileptic Disord, 22: 775–781. https://doi.org/10.1684/epd.2020.1232
Hamed SA, Tohamy AM, Oseilly AM, 2017, Vestibular function in adults with epilepsy of unknown etiology. Otol Neurotol, 38: 1217–1224. https://doi.org/10.1097/MAO.0000000000001513
Kumar A, Sharma S, 2021, Complex Partial Seizure. In: StatPearls. Treasure Island: StatPearls Publishing.
Morano A, Carnì M, Casciato S, et al., 2017, Ictal EEG/fMRI study of vertiginous seizures. Epilepsy Behav, 68: 51–56. https://doi.org/10.1016/j.yebeh.2016.12.031
Malov AG, Kulesh AA, Vshivkov MI, 2019, Familial temporal lobe epilepsy 5 with vestibular seizures (a case report). Zh Nevrol Psikhiatr Im S S Korsakova, 119: 65–69. https://doi.org/10.17116/jnevro201911911265
Hewett R, Guye M, Gavaret M, et al., 2011, Benign temporo-parieto-occipital junction epilepsy with vestibular disturbance: An underrecognized form of epilepsy? Epilepsy Behav, 21: 412–416. https://doi.org/10.1016/j.yebeh.2011.05.017
Fotuhi M, Glaun B, Quan SY, et al., 2009, Vestibular migraine: A critical review of treatment trials. J Neurol, 256: 711–716. https://doi.org/10.1007/s00415-009-5050-5