AccScience Publishing / AN / Volume 1 / Issue 2 / DOI: 10.36922/an.v1i2.71
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Associations of common variants in TAAR5, OR6C70, and GBA with hyposmia in Han Chinese individuals with Parkinson’s disease

Yi-Lun Ge1 Pu-Zhi Wang1 Jia-Hui Yan1 Wen Li1 Jin-Ru Zhang1 Hong Jin1 Ya-Ping Yang1 Fen Wang2 Dan Li3 Jing Chen1 Kai Li1* Cheng-Jie Mao1,3* Chun-Feng Liu1,2,3
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1 Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
2 Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China
3 Department of Neurology, Suqian First Hospital, Suqian, China
Advanced Neurology 2022 , 1(2), 71; https://doi.org/10.36922/an.v1i2.71
Submitted: 17 April 2022 | Accepted: 31 May 2022 | Published: 27 July 2022
© 2022 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Hyposmia is one of the cardinal symptoms of Parkinson’s disease (PD), with a considerably high prevalence rate in PD individuals. However, some individuals still retain normal olfactory function. Recent studies have shown that genetic factors may play a role in such a phenomenon. This study aimed to explore the potential genetic factors underlying the variation of olfactory function among PD individuals. Two hundred and three Han Chinese individuals with PD were recruited into this study. All the individuals underwent detailed clinical assessment conducted by experienced neurologists. High-throughput sequencing was performed to identify gene variants associated with PD. TAAR5, OR6C70, and GBA were included in the association analysis. In our study, 85 out of 203 individuals (41.9%) reported normal olfaction, and the other 118 (58.1%) reported hyposmia. Genotype and allele logistic regression models were applied to association analysis. We did not find any significant association of TAAR5 and OR6C70 with hyposmia. However, we found that GBA rs762488 was associated with increased hyposmia risk (P = 0.036, OR = 3.05, 95% CI = 1.08–8.63), while GBA rs1800438 was associated with decreased hyposmia risk (P = 0.032, OR = 0.47, 95% CI = 0.24–0.94). In conclusion, this study revealed the association of GBA with hyposmia, indicating the genetic involvement in PD hyposmia variation. However, we did not replicate previous results (TAAR5 and OR6C70) in this study. Further studies with larger sample sizes in different populations are warranted.

Keywords
Parkinson’s disease
Olfaction
TAAR5
OR6C70
GBA
Funding
None
National Key R&D Program of China
Jiangsu Provincial Key R&D Program
Jiangsu Provincial Medical Key Discipline Project
Suzhou Clinical Research Center of Neurological Disease
National Natural Science Foundation of China
Talent Support Project for Science and Teaching of the Second Affiliated Hospital of Soochow University
Pre-research Project for Doctors of the Second Affiliated Hospital of Soochow University
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Conflict of interest
None.
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Advanced Neurology, Electronic ISSN: 2810-9619, Print ISSN: TBA, Published by AccScience Publishing