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REVIEW ARTICLE

Myokines as mediators of muscle–brain crosstalk: Implications for neuroplasticity and neurodegenerative diseases

Marco Machado1* ,  Flavio Bachini2 ,  Greziene S. Silva1,3 ,  Fabiana P.C. Ramos3 ,  Alex Itaborahy4
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1 Fundação Universitária de Itaperuna, Itaperuna, RJ , Brazil
2 Bioquímica do Exercício e do Esporte Laboratório de Performance Esportiva, Nova Friburgo, RJ , Brazil
3 Programa de Pós-graduação em Cognição e Linguagem, Universidade Estadual do Norte Fluminense Darci Ribeiro (UENF), Campos dos Goytacazes, RJ , Brazil
4 Núcleo de Avaliação de Tecnologias em Saúde, Instituto Nacional de Cardiologia, Rio de Janeiro, RJ , Brazil
JCTR, 026180033 https://doi.org/10.36922/JCTR026180033
Received: 17 April 2026 | Revised: 13 August 2026 | Accepted: 28 August 2026 | Published online: 4 September 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Background: Skeletal muscle is increasingly recognized as an endocrine organ that releases bioactive factors, termed myokines, capable of mediating inter-organ communication, including signaling to the brain. Aim: To summarize current evidence on key myokines involved in muscle–brain crosstalk and their potential roles in neuroplasticity, cognition, and neurodegenerative diseases. Methods: This narrative review synthesizes findings from experimental and clinical studies addressing exercise-induced myokines, their interaction with the blood–brain barrier, and associated intracellular signaling pathways relevant to central nervous system function. Results: Multiple myokines, including fibronectin type III domain-containing protein 5 (irisin), cathepsin B, insulin-like growth factor-1, interleukin-6, interleukin-1, leukemia inhibitory factor, and lactate, have been implicated in muscle–brain communication. These factors may influence brain function by crossing or modulating the blood–brain barrier and activating signaling pathways such as protein kinase B, extracellular signal-regulated kinases, and cAMP response element-binding protein. Evidence suggests that these mechanisms contribute to increased brain-derived neurotrophic factor expression, promoting neurogenesis, synaptic plasticity, and neuroprotection. Additionally, creatine, although not a myokine, may support brain function through its role in cellular energy homeostasis. Conclusion: Myokines represent key mediators linking physical exercise to brain health, with potential implications for the prevention and management of neurodegenerative conditions. However, further studies are required to clarify their mechanisms and clinical applicability. Relevance for Patients: Understanding how exercise-induced factors influence brain function may support the development of non-pharmacological and adjunct therapeutic strategies to preserve cognitive function and reduce the risk of neurodegenerative diseases.

Graphical abstract
Keywords
Exercise
Cytokines
Inflammatory mediators
Signaling
Crosstalk
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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