AccScience Publishing / JCBP / Online First / DOI: 10.36922/JCBP025150023
ORIGINAL RESEARCH ARTICLE

Prevalence of somatic symptom disorder in Syrian patients with breast cancer: A cross-sectional study

Jamal Alshorman1 Maria Karaminasian2 Somayeh Sadeghi2 Elaheh Safari2 Hadis Abbaspourtabari2 Ruba Altahla1,3*
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1 Department of Orthopedics, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
2 Department of General Medicine, MBBS Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
3 Department of Rehabilitation, Faculty of Medicine, Al Baath University, Homs, Syria
Received: 10 April 2025 | Revised: 27 May 2025 | Accepted: 18 June 2025 | Published online: 9 September 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Breast cancer is a common cancer among women in Syria, characterized by lower incidence rates compared to those in Western countries but higher mortality. This study aims to determine the prevalence of somatic symptom disorder (SSD) among breast cancer patients in Syria and to identify disparities in demographic, clinical, and psychosocial characteristics between breast cancer patients with and without SSD. A cross-sectional survey was conducted from June to December 2024, involving 65 women with breast cancer patients randomly selected from the Al-Baath University Cancer Hospital. Participants completed a self-administered questionnaire, including validated tools for assessing SSD, anxiety, and fear of cancer recurrence. Statistical analyses such as Chi-square tests and logistic regression were performed using SPSS. Among the 65 participants, 18 (27.69%) were diagnosed with SSD. The patients with SSD reported significant levels of impairment (p<0.001) and longer symptom durations. Only 5.55% of the SSD patients reported no impairment, compared to 48.93% in the non-SSD group. Higher scores on the Patient Health Questionnaire-15, General Anxiety Disorder-7, and Fear of Cancer Recurrence-4 indicated increased psychological distress among SSD patients (all p<0.001). The results highlight a significant prevalence of SSD among breast cancer patients in Syria, emphasizing the need for routine psychological screenings and a multidisciplinary approach to care.

Keywords
Breast cancer
Prevalence
Somatic symptom disorder
Syria
Funding
None.
Conflict of interest
The authors declare they have no competing interests.
References
  1. Nahhat F, Doyya M, Zabad K, et al. Breast cancer quality of care in Syria: Screening, diagnosis, and staging. BMC Cancer. 2023;23(1):1234. doi: 10.1186/s12885-023-11740-2

 

  1. Wéber A, Vignat J, Shah R, et al. Global burden of bladder cancer mortality in 2020 and 2040 according to GLOBOCAN estimates. World J Urol. 2024;42(1):237. doi: 10.1007/s00345-024-04949-8

 

  1. Hanafi I, Alsalkini M, Husein S, Salamoon M. The delay of breast cancer diagnosis and management during the Syrian war. Cancer Epidemiol. 2023;82:102290. doi: 10.1016/j.canep.2022.102290

 

  1. Li Z, Li J, Tang L, Pang Y. Development of psychosocial oncology care in China: Consultation-liaison psychiatric service in a cancer center. Psychooncology. 2019;28(11):2247-2249. doi: 10.1002/pon.5219

 

  1. Chaturvedi SK. Psychiatric oncology: Cancer in mind. Indian J Psychiatry. 2012;54(2):111-118. doi: 10.4103/0019-5545.99529

 

  1. Dunphy L, Penna M, El-Kafsi J. Somatic symptom disorder: A diagnostic dilemma. BMJ Case Rep. 2019;12(11):e231550. doi: 10.1136/bcr-2019-231550

 

  1. Sayed D, Grider J, Strand N, et al. The American Society of Pain and Neuroscience (ASPN) evidence-based clinical guideline of interventional treatments for low back pain. J Pain Res. 2022;15:3729-3832. doi: 10.2147/jpr.S386879

 

  1. Li Z, Zhang Y, Pang Y, et al. The mediating effect of somatic symptom disorder between psychological factors and quality of life among Chinese breast cancer patients. Front Psychiatry. 2023;14:1076036. doi: 10.3389/fpsyt.2023.1076036

 

  1. Kroenke K, Zhong X, Theobald D, Wu J, Tu W, Carpenter JS. Somatic symptoms in patients with cancer experiencing pain or depression: Prevalence, disability, and health care use. Arch Intern Med. 2010;170(18):1686-1694. doi: 10.1001/archinternmed.2010.337

 

  1. Ismail A, Chabbouh A, Charro E, et al. Examining the validity and reliability of the Arabic translated version of the depression and somatic symptoms scale (A-DSSS) among the Lebanese adults. Sci Rep. 2024;14(1):5435. doi: 10.1038/s41598-024-55813-z

 

  1. Narrow WE, Clarke DE, Kuramoto SJ, et al. DSM-5 field trials in the United States and Canada, Part III: Development and reliability testing of a cross-cutting symptom assessment for DSM-5. Am J Psychiatry. 2013;170(1):71-82. doi: 10.1176/appi.ajp.2012.12071000

 

  1. Kroenke K, Spitzer RL, Williams JB. The PHQ-15: Validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med. 2002;64(2):258-266. doi: 10.1097/00006842-200203000-00008

 

  1. Sawaya H, Atoui M, Hamadeh A, Zeinoun P, Nahas Z. Adaptation and initial validation of the Patient Health Questionnaire - 9 (PHQ-9) and the Generalized Anxiety Disorder - 7 Questionnaire (GAD-7) in an Arabic speaking Lebanese psychiatric outpatient sample. Psychiatry Res. 2016;239:245-252. doi: 10.1016/j.psychres.2016.03.030

 

  1. Thewes B, Butow P, Zachariae R, Christensen S, Simard S, Gotay C. Fear of cancer recurrence: A systematic literature review of self-report measures. Psychooncology. 2012;21(6):571-587. doi: 10.1002/pon.2070

 

  1. Humphris GM, Watson E, Sharpe M, Ozakinci G. Unidimensional scales for fears of cancer recurrence and their psychometric properties: The FCR4 and FCR7. Health Qual Life Outcomes. 2018;16(1):30. doi: 10.1186/s12955-018-0850-x

 

  1. Sawma T, Choueiri P. The influence of family functioning on the severity of fear of cancer recurrence: A cross-sectional study in a sample of breast cancer survivors of Lebanese women. Eur J Oncol Nurs. 2022;60:102169. doi: 10.1016/j.ejon.2022.102169

 

  1. Alalawi NM, Al Salmani AA, Aljabri MK, et al. Epidemiology and prevalence of somatic symptom disorder at the primary care level in Muscat, Oman: A cross-sectional study. Int J Psychiatry Med. 2023;58(3):284-294. doi: 10.1177/00912174221088263

 

  1. Bhatia S, Landier W, Paskett ED, et al. Rural-urban disparities in cancer outcomes: Opportunities for future research. J Natl Cancer Inst. 2022;114(7):940-952. doi: 10.1093/jnci/djac030

 

  1. Chen ZH, Yang KB, Zhang YZ, et al. Assessment of modifiable factors for the association of marital status with cancer-specific survival. JAMA Netw Open. 2021;4(5):e2111813. doi: 10.1001/jamanetworkopen.2021.11813

 

  1. Hergenrather KC, Emmanuel D, McGuire-Kuletz M, Rhodes SD. Employment as a social determinant of health: Exploring the relationship between neurocognitive function and employment status. Rehabil Res Policy Educ. 2018;32(2):101-122. doi: 10.1891/2168-6653.32.2.101

 

  1. Altahla R, Alshorman J, Ali I, Tao X. A cross-sectional survey on the effects of the COVID-19 pandemic on psychological well-being and quality of life in people with spinal cord injury. J Orthop Surg Res. 2024;19(1):564. doi: 10.1186/s13018-024-04955-x

 

  1. Altahla R, Alshorman J, Ali-Shah SZ, Nasb M, Tao X. Quality of life and subjective well-being comparison between traumatic, nontraumatic chronic spinal cord injury, and healthy individuals in China. PeerJ. 2024;12:e18709. doi: 10.7717/peerj.18709

 

  1. Bultz BD, Carlson LE. Emotional distress: The sixth vital sign-future directions in cancer care. Psychooncology. 2006;15(2):93-95. doi: 10.1002/pon.1022

 

  1. Lin C, Clark R, Tu P, Bosworth HB, Zullig LL. Breast cancer oral anti-cancer medication adherence: A systematic review of psychosocial motivators and barriers. Breast cancer Res Treat. 2017;165(2):247-260. doi: 10.1007/s10549-017-4317-2

 

  1. Okur Güney ZE, Sattel H, Witthöft M, Henningsen P. Emotion regulation in patients with somatic symptom and related disorders: A systematic review. PLoS One. 2019;14(6):e0217277. doi: 10.1371/journal.pone.0217277

 

  1. Turk DC. The role of psychological factors in chronic pain. Acta Anaesthesiol Scand. 1999;43(9):885-888. doi: 10.1034/j.1399-6576.1999.430904.x

 

  1. Linton SJ, Shaw WS. Impact of psychological factors in the experience of pain. Phys Ther. 2011;91(5):700-711. doi: 10.2522/ptj.20100330

 

  1. Gilam G, Gross JJ, Wager TD, Keefe FJ, Mackey SC. What is the relationship between pain and emotion? Bridging constructs and communities. Neuron. 2020;107(1):17-21. doi: 10.1016/j.neuron.2020.05.024

 

  1. Lumley MA, Cohen JL, Borszcz GS, et al. Pain and emotion: A biopsychosocial review of recent research. J Clin Psychol. 2011;67(9):942-968. doi: 10.1002/jclp.20816

 

  1. Götze H, Taubenheim S, Dietz A, Lordick F, Mehnert‐ Theuerkauf A. Fear of cancer recurrence across the survivorship trajectory: Results from a survey of adult long‐term cancer survivors. Psychooncology. 2019;28(10):2033-2041. doi: 10.1002/pon.5188

 

  1. Tong F, Zhou Y, Xu Y, et al. Supramolecular Nanomedicines Based on Host-guest Interactions of Cyclodextrins. United States: Wiley Online Library; 2023. p. 20210111.

 

  1. Yan M, Wu S, Wang Y, et al. Recent progress of supramolecular chemotherapy based on host–guest interactions. Adv Mater. 2024;36(21):2304249. doi: 10.1002/adma.202304249

 

  1. Dai Y, Sun J, Zhang X, et al. Supramolecular assembly boosting the phototherapy performances of BODIPYs. Coordination Chem Rev. 2024;517:216054. doi: 10.1016/j.ccr.2024.216054
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Journal of Clinical and Basic Psychosomatics, Electronic ISSN: 2972-4414 Print ISSN: 3060-8562, Published by AccScience Publishing