Supplementation of Carrot Incorporated Paneer Attenuates Diabetes through its Antioxidant Potential in Streptozotocin-Nicotinamide-Induced Diabetic Rats
*These authors contributed equally to this work.
Background: The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening
on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.
Objective: The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.
Materials and Methods: Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).
Results: Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.
Conclusion: Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.
Uddandrao, V.V.; Brahmanaidu, P.; Ravindarnaik, R.; Suresh, P.; Vadivukkarasi, S.; Saravanan, G. Restorative potentiality of s-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide induced diabetic rats. Eur. J. Nutr., 2018, DOI: 10.1007/s00394-018-1795-x.
Naidu, P.B.; Uddandrao, S.; Naik, R.R.; Suresh, P.; Meriga, B.; Begum, M.S. Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats. Mol. Cell. Endocrinol., 2016, 419, 139-147.
Kandasamy, N.; Ashokkumar, N. Myricetin modulates streptozotocin-cadmium induced oxidative stress in long term experimental diabetic nephrotoxic rats. J. Funct. Foods, 2013, 5(3), 1499-1477.
Uddandrao, V.V.; Brahmanaidu, P.; Meriga. B.; Saravanan, G. The potential role of S-allylcysteine as antioxidant against various disorders in animal models. Oxid. Antioxid. Med. Sci., 2016, 5(3), 79-86.
Agrawal, S.P. Innovations in production of indigenous milk products. In: Dairy India 2007. Dairy India Yearbook. 6th ed. New Delhi: Priyadarshini Vihar, 2007. p. 413-414.
Raja, J.; Punoo, H.A.; Masoodi, F.A. Comparative study of soy paneer prepared from soymilk, blends of soymilk and skimmed milk. J. Food Process. Technol., 2014, 5(2), 301.
Raveendran, P.N.; Uddandrao, V.V.; Saravanan, G.; Brahmanaidu, P.; Vadivukkarasi, S. An endeavour to formulate carrot juice incorporated buffalo milk paneer as better nutritional source; organoleptic and nutritional evaluation. Indian J. Diary Sci., 2018, 71(2), 1-5.
Kakkar, P.; Das, B.; Viswanathan, P.N. Amodified spectrophotometric assay of SOD. Indian J. Biochem. Biophys., 1984, 21(2), 130-132.
Aebi, H. Catalase in vitro. Methods Enzymol, 1984, 105(C), 121-126.
Paglia, D.; Valentine, W. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med., 1967, 70(1), 158-169.
Beutler, E.; Kelly, B.M. The effect of sodium nitrate on RBC glutathione. Experienta, 1963, 19, 96-97.
Brahmanaidu, P.; Uddandrao, V.V.; Vadivukkarsi, S.; Naik, R.R.; Pothani, S.; Begum, M.S.; Varatharaju, C.; Meriga, B.; Kalaivani, A.; Saravanan, G. Reversal of endothelial dysfunction in aorta of streptozotocin nicotinamide-induced Type-2 diabetic rats by s-allylcysteine. Mol. Cell. Biochem., 2017, 432(1-2), 25-32.
Saravanan, G.; Ponmurugan, P. Ameliorative potential of s-allylcysteine on oxidative stress in STZ induced diabetic rats. Chem. Bio. Int., 2011, 189(1-2), 100-106.
Brahmanaidu, P.; Uddandrao, V.V.; Pothani, S.; Naik, R.R.; Begum, M.S.; Varatharaju, C.; Pandiyan, R.; Saravanan, G. Effects of S-allylcysteine on biomarkers of polyol pathway in experimental type II diabetes in rats. Can. J. Diabetes, 2016, 40(5), 442-448.
Uddandrao, V.V.; Brahmanaidu, P.; Saravanan, G. Therapeutical perspectives of s-allylcysteine: Effect on diabetes and other disorders in animal models. Cardiovasc. Hematol. Agents Med. Chem., 2017, 15(2), 71-77.
U d d a n d r a o , V. V. ; B r a h m a n a i d u , P. ; N i v e d h a , P. R . ; Vadivukkarasi, S.; Saravanan, G. Beneficial role of some natural products to attenuate the diabetic cardiomyopathy through Nrf2 pathway in cell culture and animal models. Cardiovasc. Toxicol., 2018, 18(3), 199-205.
Hefnawy, T.; El-Shourbagy, A.G.; Ramadan, M.F. Phenolic extracts of carrot, grape leaf and turmeric powder: antioxidant potential and application in biscuits. J. Food Meas. Charact., 2016, 10(3), 576-583.