AccScience Publishing / IJB / Volume 9 / Issue 5 / DOI: 10.18063/ijb.757
Cite this article
115
Download
571
Views
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
RESEARCH ARTICLE

Functional materials of 3D bioprinting for wound dressings and skin tissue engineering applications: A review

Huan Fang1,2† Jie Xu1,2† Hailin Ma1,2 Jiaqi Liu1 Erpai Xing1 Yuen Yee Cheng3 Hong Wang4 * Yi Nie2* Bo Pan5* Kedong Song1*
Show Less
1 State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China
2 Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, Henan, China
3 Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, NSW 2007, Australia
4 Department of Orthopaedics, Dalian Municipal Central Hospital Affiliated of Dalian University of Technology, Dalian 116033, China
5 Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, China
Submitted: 10 August 2022 | Accepted: 31 January 2023 | Published: 18 May 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

The skin plays an important role in vitamin D synthesis, humoral balance, temperature regulation, and waste excretion. Due to the complexity of the skin, fluids loss, bacterial infection, and other life-threatening secondary complications caused by skin defects often lead to the damage of skin functions. 3D bioprinting technology, as a customized and precise biomanufacturing platform, can manufacture dressings and tissue engineering scaffolds that accurately simulate tissue structure, which is more conducive to wound healing. In recent years, with the development of emerging technologies, an increasing number of 3D-bioprinted wound dressings and skin tissue engineering scaffolds with multiple functions, such as antibacterial, antiinflammatory, antioxidant, hemostatic, and antitumor properties, have significantly improved wound healing and skin treatment. In this article, we review the process of wound healing and summarize the classification of 3D bioprinting technology. Following this, we shift our focus on the functional materials for wound dressing and skin tissue engineering, and also highlight the research progress and development direction of 3D-bioprinted multifunctional wound healing materials.

Keywords
Functional materials
Wound healing
3D bioprinting
Dressing
Skin tissue engineering
References

Moeini A, Pedram P, Makvandi P, et al., 2020, Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review. Carbohydr Polym, 233:115839. https://doi.org/10.1016/j.carbpol.2020.115839

Kus KJB, Ruiz ES, 2020, Wound dressings—A practical review. Curr Derm Rep, 9(4):298–308. https://doi.org/10.1007/s13671-020-00319-w

Li R, Liu K, Huang X, et al., 2022, Bioactive materials promote wound healing through modulation of cell behaviors. Adv Sci (Weinh), 9(10):e2105152. https://doi.org/10.1002/advs.202105152

Simoes D, Miguel SP, Ribeiro MP, et al., 2018, Recent advances on antimicrobial wound dressing: A review. Eur J Pharm Biopharm, 127:130–141. https://doi.org/10.1016/j.ejpb.2018.02.022

Zhang K, Wang Y, Wei Q, et al., 2021, Design and fabrication of sodium alginate/carboxymethyl cellulose sodium blend hydrogel for artificial skin. Gels, 7(3):115. https://doi.org/10.3390/gels7030115

Farahani M, Shafiee A, 2021, Wound healing: From passive to smart dressings. Adv Healthc Mater, 10(16):e2100477. https://doi.org/10.1002/adhm.202100477

Wang F, Wang S, Nan L, et al., 2022, Conductive adhesive and antibacterial zwitterionic hydrogel dressing for therapy of full-thickness skin wounds. Front Bioeng Biotechnol, 10:833887. https://doi.org/10.3389/fbioe.2022.833887

Katiyar S, Singh D, Kumari S, et al., 2022, Novel strategies for designing regenerative skin products for accelerated wound healing. 3 Biotech, 12(11):316. https://doi.org/10.1007/s13205-022-03331-y

Da LC, Huang YZ, Xie HQ, 2017, Progress in development of bioderived materials for dermal wound healing. Regen Biomater, 4(5):325–334. https://doi.org/10.1093/rb/rbx025

 

Xu J, Fang H, Zheng S, et al., 2021, A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering. Int J Biol Macromol, 187:840–849. https://doi.org/10.1016/j.ijbiomac.2021.07.162

Wang K, Wang J, Li L, et al., 2020, Novel nonreleasing antibacterial hydrogel dressing by a one-pot method. ACS Biomater Sci Eng, 6(2):1259–1268. https://doi.org/10.1021/acsbiomaterials.9b01812

 

Guo Y, Huang J, Fang Y, et al., 2022, 1D, 2D, and 3D scaffolds promoting angiogenesis for enhanced wound healing. Chem Eng J, 437:134690. https://doi.org/10.1016/j.cej.2022.134690

Brock WD, Bearden W, Tann T, et al., 2003, Autogenous dermis skin grafts in lower eyelid reconstruction. Ophthalmic Plast Reconstr Surg, 19(5):394–397. https://doi.org/10.1097/01.IOP.0000087070.83353.99

 

Ali JM, Catarino P, Dunning J, et al., 2016, Could sentinel skin transplants have some utility in solid organ transplantation? Transplant Proc, 48(8):2565–2570. https://doi.org/10.1016/j.transproceed.2016.06.040

Shi C, Zhu Y, Su Y, et al., 2006, Stem cells and their applications in skin-cell therapy. Trends Biotechnol, 24(1):48–52. https://doi.org/10.1016/j.tibtech.2005.11.003

Pajardi G, Rapisarda V, Somalvico F, et al., 2016, Skin substitutes based on allogenic fibroblasts or keratinocytes for chronic wounds not responding to conventional therapy: A retrospective observational study. Int Wound J, 13(1):44–52. https://doi.org/10.1111/iwj.12223

Rastin H, Ramezanpour M, Hassan K, et al., 2021, 3D bioprinting of a cell-laden antibacterial polysaccharide hydrogel composite. Carbohydr Polym, 264:117989. https://doi.org/10.1016/j.carbpol.2021.117989

 

Yi T, Huang S, Liu G, et al., 2018, Bioreactor synergy with 3D scaffolds: New era for stem cells culture. ACS Appl Bio Mater, 1(2):193–209. https://doi.org/10.1021/acsabm.8b00057

Xue J, Wang X, Wang E, et al., 2019, Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing. Acta Biomater, 100:270–279. https://doi.org/10.1016/j.actbio.2019.10.012

 

Radmanesh S, Shabangiz S, Koupaei N, et al., 2022, 3D printed bio polymeric materials as a new perspective for wound dressing and skin tissue engineering applications: A review. J Polym Res, 29(2):50. https://doi.org/10.1007/s10965-022-02899-6

Aderibigbe BA, Buyana B, 2018, Alginate in wound dressings. Pharmaceutics, 10(2):42. https://doi.org/10.3390/pharmaceutics10020042

Yu P, Zhong W, 2021, Hemostatic materials in wound care. Burns Trauma, 9:tkab019. https://doi.org/10.1093/burnst/tkab019

Pelletier DA, Suresh AK, Holton GA, et al., 2010, Effects of engineered cerium oxide nanoparticles on bacterial growth and viability. Appl Environ Microbiol, 76(24):7981–7989. https://doi.org/10.1128/AEM.00650-10

Yang X, Liu W, Li N, et al., 2017, Design and development of polysaccharide hemostatic materials and their hemostatic mechanism. Biomater Sci, 5(12):2357–2368. https://doi.org/10.1039/c7bm00554g

Wan W, Cai F, Huang J, et al., 2019, A skin-inspired 3D bilayer scaffold enhances granulation tissue formation and anti-infection for diabetic wound healing. J Mater Chem B, 7(18):2954–2961. https://doi.org/10.1039/c8tb03341b

Zhang B, Luo Y, Ma L, et al., 2018, 3D bioprinting: An emerging technology full of opportunities and challenges. Bio-Des Manuf, 1(1):2–13. https://doi.org/10.1007/s42242-018-0004-3

Chen X, Han S, Wu W, et al., 2022, Harnessing 4D printing bioscaffolds for advanced orthopedics. Small, 18(36):e2106824. https://doi.org/10.1002/smll.202106824

 

Hockaday LA, Kang KH, Colangelo NW, et al., 2012, Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds. Biofabrication, 4(3):035005. https://doi.org/10.1088/1758-5082/4/3/035005

Zhong H, Huang J, Wu J, et al., 2021, Electrospinning nanofibers to 1D, 2D, and 3D scaffolds and their biomedical applications. Nano Res, 15(2):787–804. https://doi.org/10.1007/s12274-021-3593-7

Song W, Yao B, Zhu D, et al., 2022, 3D-bioprinted microenvironments for sweat gland regeneration. Burns Trauma, 10:tkab044. https://doi.org/10.1093/burnst/tkab044

Liu C, Wang Z, Wei X, et al., 2021, 3D printed hydrogel/PCL core/shell fiber scaffolds with NIR-triggered drug release for cancer therapy and wound healing. Acta Biomater, 131: 314–325. https://doi.org/10.1016/j.actbio.2021.07.011

Zhao C, Chen R, Chen Z, et al., 2021, Bioinspired multifunctional cellulose nanofibril-based in situ liquid wound dressing for multiple synergistic therapy of the postoperative infected wound. ACS Appl Mater Interfaces, 13(43):51578–51591. https://doi.org/10.1021/acsami.1c18221

 

Gul A, Gallus I, Tegginamath A, et al., 2021, Electrospun antibacterial nanomaterials for wound dressings applications. Membranes (Basel), 11(12):908. https://doi.org/10.3390/membranes11120908

Chouhan D, Dey N, Bhardwaj N, et al., 2019, Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances. Biomaterials, 216:119267. https://doi.org/10.1016/j.biomaterials.2019.119267

Lansdown A, 2002, Calcium a potential central regulator in wound healing in the skin. Wound Repair Regen, 10(5): 271–285.https://doi.org/10.1046/j.1524-475X.2002.10502.x

Homaeigohar S, Boccaccini AR, 2020, Antibacterial biohybrid nanofibers for wound dressings. Acta Biomater, 107:25–49. https://doi.org/10.1016/j.actbio.2020.02.022

Liang Y, He J, Guo B, 2021, Functional hydrogels as wound dressing to enhance wound healing. ACS Nano, 15(8):12687– 12722. https://doi.org/10.1021/acsnano.1c04206

Wang F, Gao Y, Li H, et al., 2022, Effect of natural-based biological hydrogels combined with growth factors on skin wound healing. Nanotechnol Rev, 11(1):2493–2512. https://doi.org/10.1515/ntrev-2022-0122

Wang H, Xu Z, Zhao M, et al., 2021, Advances of hydrogel dressings in diabetic wounds. Biomater Sci, 9(5):1530–1546. https://doi.org/10.1039/d0bm01747g

Brown MS, Ashley B, Koh A, 2018, Wearable technology for chronic wound monitoring: Current dressings, advancements, and future prospects. Front Bioeng Biotechnol, 6:47. https://doi.org/10.3389/fbioe.2018.00047

Tang N, Zheng Y, Cui D, et al., 2021, Multifunctional dressing for wound diagnosis and rehabilitation. Adv Healthc Mater, 10(22):e2101292. https://doi.org/10.1002/adhm.202101292

Hao R, Cui Z, Zhang X, et al., 2021, Rational design and preparation of functional hydrogels for skin wound healing. Front Chem, 9:839055. https://doi.org/10.3389/fchem.2021.839055

Sharifi S, Hajipour MJ, Gould L, et al., 2021, Nanomedicine in healing chronic wounds: Opportunities and Challenges. Mol Pharm, 18(2):550–575. https://doi.org/10.1021/acs.molpharmaceut.0c00346

Mao H, Yang L, Zhu H, et al., 2020, Recent advances and challenges in materials for 3D bioprinting. Prog Nat Sci Mater Int, 30(5):618–634. https://doi.org/10.1016/j.pnsc.2020.09.015

Bishop ES, Mostafa S, Pakvasa M, et al., 2017, 3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends. Genes Dis, 4(4):185–195. https://doi.org/10.1016/j.gendis.2017.10.002

Askari M, Afzali Naniz M, Kouhi M, et al., 2021, Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: A comprehensive review with focus on advanced fabrication techniques. Biomater Sci, 9(3):535–573. https://doi.org/10.1039/d0bm00973c

Vedakumari WS, Ayaz N, Karthick AS, et al., 2017, Quercetin impregnated chitosan-fibrin composite scaffolds as potential wound dressing materials—Fabrication, characterization and in vivo analysis. Eur J Pharm Sci, 97:106–112. https://doi.org/10.1016/j.ejps.2016.11.012

Li Y, Zhang W, Niu J, et al., 2012, Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal-oxide nanoparticles. ACS Nano, 6(6):5164–5173. https://doi.org/10.1021/nn300934k

Yu H, Gong W, Mei J, et al., 2022, The efficacy of a paeoniflorin-sodium alginate-gelatin skin scaffold for the treatment of diabetic wound: An in vivo study in a rat model. Biomed Pharmacother, 151:113165. https://doi.org/10.1016/j.biopha.2022.113165

Seon GM, Lee MH, Koo MA, et al., 2021, A collagen-AS/ epsilonPLL bilayered artificial substitute regulates anti-inflammation and infection for initial inflamed wound healing. Biomater Sci, 9(20):6865–6878. https://doi.org/10.1039/d1bm01071a

Sadidi H, Hooshmand S, Ahmadabadi A, et al., 2020, Cerium oxide nanoparticles (nanoceria): Hopes in soft tissue engineering. Molecules, 25(19):4559. https://doi.org/10.3390/molecules25194559

Liang Y, Chen B, Li M, et al., 2020, injectable antimicrobial conductive hydrogels for wound disinfection and infectious wound healing. Biomacromolecules, 21(5):1841–1852. https://doi.org/10.1021/acs.biomac.9b01732

Tang Q, Plank TN, Zhu T, et al., 2019, Self-assembly of metallo-nucleoside hydrogels for injectable materials that promote wound closure. ACS Appl Mater Interfaces, 11(22):19743–19750. https://doi.org/10.1021/acsami.9b02265

Xu Z, Han S, Gu Z, et al., 2020, advances and impact of antioxidant hydrogel in chronic wound healing. Adv Healthc Mater, 9(5):e1901502. https://doi.org/10.1002/adhm.201901502

Tang P, Han L, Li P, et al., 2019, Mussel-inspired electroactive and antioxidative scaffolds with incorporation of polydopamine-reduced graphene oxide for enhancing skin wound healing. ACS Appl Mater Interfaces, 11(8):7703– 7714. https://doi.org/10.1021/acsami.8b18931

 

Nguyen TTT, Ghosh C, Hwang SG, et al., 2013, Characteristics of curcumin-loaded poly (lactic acid) nanofibers for wound healing. J Mater Sci, 48(20):7125–7133. https://doi.org/10.1007/s10853-013-7527-y

Liu L, Hu E, Yu K, et al., 2021, Recent advances in materials for hemostatic management. Biomater Sci, 9(22):7343–7378. https://doi.org/10.1039/d1bm01293b

Du X, Wu L, Yan H, et al., 2021, Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing. Nat Commun, 12(1):4733. https://doi.org/10.1038/s41467-021-24972-2

Futalan CM, Kan C-C, Dalida ML, et al., 2011, Comparative and competitive adsorption of copper, lead, and nickel using chitosan immobilized on bentonite. Carbohydr Polym, 83(2):528–536. https://doi.org/10.1016/j.carbpol.2010.08.013

Biranje SS, Sun J, Cheng L, et al., 2022, Development of cellulose nanofibril/casein-based 3D composite hemostasis scaffold for potential wound-healing application. ACS Appl Mater Interfaces, 14(3):3792–3808. https://doi.org/10.1021/acsami.1c21039

Gao D, Wang Z, Wu Z, et al., 2020, 3D-printing of solvent exchange deposition modeling (SEDM) for a bilayered flexible skin substitute of poly (lactide-co-glycolide) with bioorthogonally engineered EGF. Mater Sci Eng C Mater Biol Appl, 112:110942. https://doi.org/10.1016/j.msec.2020.110942

Lee WH, Ren H, Wu J, et al., 2016, Electrochemically modulated nitric oxide release from flexible silicone rubber patch: Antimicrobial activity for potential wound healing applications. ACS Biomater Sci Eng, 2(9):1432–1435. https://doi.org/10.1021/acsbiomaterials.6b00360

Sajadimajd S, Bahramsoltani R, Iranpanah A, et al., 2020, Advances on natural polyphenols as anticancer agents for skin cancer. Pharmacol Res, 151:104584. https://doi.org/10.1016/j.phrs.2019.104584

Bal-Ozturk A, Ozkahraman B, Ozbas Z, et al., 2021, Advancements and future directions in the antibacterial wound dressings—A review. J Biomed Mater Res B Appl Biomater, 109(5):703–716. https://doi.org/10.1002/jbm.b.34736

Fang H, Wang J, Li L, et al., 2019, A novel high-strength poly(ionic liquid)/PVA hydrogel dressing for antibacterial applications. Chem Eng J, 365:153–164. https://doi.org/10.1016/j.cej.2019.02.030

Zheng L, Li S, Luo J, et al., 2020, Latest advances on bacterial cellulose-based antibacterial materials as wound dressings. Front Bioeng Biotechnol, 8:593768. https://doi.org/10.3389/fbioe.2020.593768

Thill A, Zeyons O, Spalla O, et al., 2006, Cytotoxicity of CeO2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism. Environ Sci Technol, 40(19):6151–6156. https://doi.org/10.1021/es060999b

Guo Z, Zhang Z, Zhang N, et al., 2022, A mg(2+)/ polydopamine composite hydrogel for the acceleration of infected wound healing. Bioact Mater, 15:203–213. https://doi.org/10.1016/j.bioactmat.2021.11.036

Subramanian AK, Prabhakar R, Vikram NR, et al., 2022, In vitro anti-inflammatory activity of silymarin/ hydroxyapatite/chitosan nanocomposites and its cytotoxic effect using brine shrimp lethality assay. J Popul Ther Clin Pharmacol, 28(2):e71–e77. https://doi.org/10.47750/jptcp.2022.874

Kim H, Kim BH, Huh BK, et al., 2017, Surgical suture releasing macrophage-targeted drug-loaded nanoparticles for an enhanced anti-inflammatory effect. Biomater Sci, 5(8):1670–1677. https://doi.org/10.1039/c7bm00345e

He L, Hong G, Zhou L, et al., 2019, Asiaticoside, a component of centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappaB signaling pathways. J Cell Physiol, 234(4):4267–4276. https://doi.org/10.1002/jcp.27195

Talikowska M, Fu X, Lisak G, 2019, Application of conducting polymers to wound care and skin tissue engineering: A review. Biosens Bioelectron, 135:50–63. https://doi.org/10.1016/j.bios.2019.04.001

Guo B, Ma PX, 2018, Conducting polymers for tissue engineering. Biomacromolecules, 19(6):1764–1782. https://doi.org/10.1021/acs.biomac.8b00276

Zhou L, Zheng H, Wang S, et al., 2020, Biodegradable conductive multifunctional branched poly(glycerol-amino acid)-based scaffolds for tumor/infection-impaired skin multimodal therapy. Biomaterials, 262:120300. https://doi.org/10.1016/j.biomaterials.2020.120300

Ou Q, Zhang S, Fu C, et al., 2021, More natural more better: Triple natural anti-oxidant puerarin/ferulic acid/ polydopamine incorporated hydrogel for wound healing. J Nanobiotechnology, 19(1):237. https://doi.org/10.1186/s12951-021-00973-7

Ren Y, Zhang D, He Y, et al., 2021, Injectable and antioxidative HT/QGA hydrogel for potential application in wound healing. Gels, 7(4):204. https://doi.org/10.3390/gels7040204

Zhao X, Wu H, Guo B, et al., 2017, Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials, 122:34–47.https://doi.org/10.1016/j.biomaterials.2017.01.011

 

Dominguez-Robles J, Martin NK, Fong ML, et al., 2019, Antioxidant PLA composites containing lignin for 3D Printing applications: A potential material for healthcare applications. Pharmaceutics, 11(4):165. https://doi.org/10.3390/pharmaceutics11040165

Comino-Sanz IM, Lopez-Franco MD, Castro B, et al., 2021, The role of antioxidants on wound healing: A review of the current evidence. J Clin Med, 10(16):3558. https://doi.org/10.3390/jcm10163558

Viana-Mendieta P, Sanchez ML, Benavides J, 2022, Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants. Int Wound J, 19(1):100–113. https://doi.org/10.1111/iwj.13602

 

Huang Y, Zhao X, Zhang Z, et al., 2020, Degradable gelatin-based IPN cryogel hemostat for rapidly stopping deep noncompressible hemorrhage and simultaneously improving wound healing. Chem Mater, 32(15):6595–6610. https://doi.org/10.1021/acs.chemmater.0c02030

 

Sung YK, Lee DR, Chung DJ, 2021, Advances in the development of hemostatic biomaterials for medical application. Biomater Res, 25(1):37. https://doi.org/10.1186/s40824-021-00239-1

Hu Z, Zhang DY, Lu ST, et al., 2018, Chitosan-based composite materials for prospective hemostatic applications. Mar Drugs, 16(8):273. https://doi.org/10.3390/md16080273

Biranje SS, Sun J, Shi Y, et al., 2021, Polysaccharide-based hemostats: recent developments, challenges, and future perspectives. Cellulose, 28(14):8899–8937. https://doi.org/10.1007/s10570-021-04132-x

Zhong Y, Hu H, Min N, et al., 2021, Application and outlook of topical hemostatic materials: A narrative review. Ann Transl Med, 9(7):577. https://doi.org/10.21037/atm-20-7160

Duarte AP, Coelho JF, Bordado JC, et al., 2012, Surgical adhesives: Systematic review of the main types and development forecast. Prog Polym Sci, 37(8):1031–1050. https://doi.org/10.1016/j.progpolymsci.2011.12.003

Zheng Y, Ma W, Yang Z, et al., 2022, An ultralong hydroxyapatite nanowire aerogel for rapid hemostasis and wound healing. Chem Eng J, 430:132912. https://doi.org/10.1016/j.cej.2021.132912

Zhou LY, Fu J, He Y, 2020, A review of 3D printing technologies for soft polymer materials. Adv Funct Mater, 30(28):2000187. https://doi.org/10.1002/adfm.202000187

Yang Y, Gao W, 2019, Wearable and flexible electronics for continuous molecular monitoring. Chem Soc Rev, 48(6):1465–1491. https://doi.org/10.1039/c7cs00730b

Shintake J, Cacucciolo V, Floreano D, et al., 2018, Soft robotic grippers. Adv Mater, 30(29):1707035. https://doi.org/10.1002/adma.201707035

Zhu C, Ninh C, Bettinger CJ, 2014, Photoreconfigurable polymers for biomedical applications: Chemistry and macromolecular engineering. Biomacromolecules, 15(10):3474–3494. https://doi.org/10.1021/bm500990z

Kim TH, An DB, Oh SH, et al., 2015, Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing-thawing method to investigate stem cell differentiation behaviors. Biomaterials, 40:51–60. https://doi.org/10.1016/j.biomaterials.2014.11.017

Guvendiren M, Molde J, Soares RM, et al., 2016, Designing biomaterials for 3D printing. ACS Biomater Sci Eng, 2(10):1679–1693. https://doi.org/10.1021/acsbiomaterials.6b00121

Wang P, Wang C, Liu C, 2021, Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration. Oncol Lett, 21(1):59. https://doi.org/10.3892/ol.2020.12321

Jain S, Chandra V, Kumar Jain P, et al., 2019, Comprehensive review on current developments of quinoline-based anticancer agents. Arab J Chem, 12(8):4920–4946. https://doi.org/10.1016/j.arabjc.2016.10.009

 

Bagheri B, Zarrintaj P, Surwase SS, et al., 2019, Self-gelling electroactive hydrogels based on chitosan-aniline oligomers/ agarose for neural tissue engineering with on-demand drug release. Colloids Surf B Biointerfaces, 184:110549. https://doi.org/10.1016/j.colsurfb.2019.110549

Qiu M, Wang D, Liang W, et al., 2018, Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy. Proc Natl Acad Sci U S A, 115(3):501–506. https://doi.org/10.1073/pnas.1714421115

Ghofrani A, Taghavi L, Khalilivavdareh B, et al., 2022, Additive manufacturing and advanced functionalities of cardiac patches: A review. Eur Polym J, 174:111332. https://doi.org/10.1016/j.eurpolymj.2022.111332

Han S, Wu J, 2022, Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy. Bioact Mater, 17:300–319. https://doi.org/10.1016/j.bioactmat.2022.01.020

Bhar B, Chouhan D, Pai N, et al., 2021, Harnessing multifaceted next-generation technologies for improved skin wound healing. ACS Appl Biol Mater, 4(11):7738–7763. https://doi.org/10.1021/acsabm.1c00880

Lee M, Rizzo R, Surman F, et al., 2020, Guiding lights: Tissue bioprinting using photoactivated materials. Chem Rev, 120(19):10950–11027. https://doi.org/10.1021/acs.chemrev.0c00077

Long J, Etxeberria AE, Nand AV, et al., 2019, A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery. Mater Sci Eng C Mater Biol Appl, 104:109873. https://doi.org/10.1016/j.msec.2019.109873

Park J, Wetzel I, Dreau D, et al., 2018, 3D miniaturization of human organs for drug discovery. Adv Healthc Mater, 7(2):1700551. https://doi.org/10.1002/adhm.201700551

Gudapati H, Dey M, Ozbolat I, 2016, A comprehensive review on droplet-based bioprinting: Past, present and future. Biomaterials, 102:20–42. https://doi.org/10.1016/j.biomaterials.2016.06.012

Gao C, Lu C, Jian Z, et al., 2021, 3D bioprinting for fabricating artificial skin tissue. Colloids Surf B Biointerfaces, 208:112041. https://doi.org/10.1016/j.colsurfb.2021.112041

Kim JH, Yoo JJ, Lee SJ, 2016, Three-dimensional cell-based bioprinting for soft tissue regeneration. Tissue Eng Regen Med, 13(6):647–662. https://doi.org/10.1007/s13770-016-0133-8

Derakhshanfar S, Mbeleck R, Xu K, et al., 2018, 3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances. Bioact Mater, 3(2):144–156. https://doi.org/10.1016/j.bioactmat.2017.11.008

Wang Y, Yuan X, Yao B, et al., 2022, Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing. Bioact Mater, 17:178–194. https://doi.org/10.1016/j.bioactmat.2022.01.024

Fairag R, Rosenzweig DH, Ramirez-Garcialuna JL, et al., 2019, Three-dimensional printed polylactic acid scaffolds promote bone-like matrix deposition in vitro. ACS Appl Mater Interfaces, 11(17):15306–15315. https://doi.org/10.1021/acsami.9b02502

Tan SH, Ngo ZH, Sci DB, et al., 2022, Recent advances in the design of three-dimensional and bioprinted scaffolds for full-thickness wound healing. Tissue Eng. Part B, Rev, 28(1):160–181. https://doi.org/10.1089/ten.TEB.2020.0339

Guillotin B, Souquet A, Catros S, et al., 2010, Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials, 31(28):7250–7256. https://doi.org/10.1016/j.biomaterials.2010.05.055

Zhu W, Ma X, Gou M, et al., 2016, 3D printing of functional biomaterials for tissue engineering. Curr Opin Biotechnol, 40:103–112. https://doi.org/10.1016/j.copbio.2016.03.014

Song Y, Chen X, Zhou J, et al., 2022, Research on performance of passive heat supply tower based on the back propagation neural network. Energy, 250:123762. https://doi.org/10.1016/j.energy.2022.123762

Xu J, Zheng S, Hu X, et al., 2020, Advances in the research of bioinks based on natural collagen, polysaccharide and their derivatives for skin 3D bioprinting. Polymers, 12(6):1237. https://doi.org/10.3390/polym12061237

Chen A, Qu C, Shi Y, et al., 2020, Manufacturing strategies for solid electrolyte in batteries. Front Energy Res, 8:571440. https://doi.org/10.3389/fenrg.2020.571440

Antezana PE, Municoy S, Alvarez-Echazu MI, et al., 2022, The 3D bioprinted scaffolds for wound healing. Pharmaceutics, 14(2):464. https://doi.org/10.3390/pharmaceutics14020464

Augustine R, 2018, Skin bioprinting: A novel approach for creating artificial skin from synthetic and natural building blocks. Prog Biomater, 7(2):77–92. https://doi.org/10.1007/s40204-018-0087-0

Cui X, Dean D, Ruggeri ZM, et al., 2010, Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells. Biotechnol Bioeng, 106(6):963–969. https://doi.org/10.1002/bit.22762

Ostrovidov S, Salehi S, Costantini M, et al., 2019, 3D bioprinting in skeletal muscle tissue engineering. Small, 15(24):e1805530. https://doi.org/10.1002/smll.201805530

Gao G, Cui X, 2016, Three-dimensional bioprinting in tissue engineering and regenerative medicine. Biotechnol Lett, 38(2):203–211. https://doi.org/10.1007/s10529-015-1975-1

Boland T, Xu T, Damon B, et al., 2006, Application of inkjet printing to tissue engineering. Biotechnol J, 1(9):910–917.

https://doi.org/10.1002/biot.200600081

Saunders RE, Derby B, 2014, Inkjet printing biomaterials for tissue engineering: Bioprinting. Int Mater Rev, 59(8): 430–448. https://doi.org/10.1179/1743280414y.0000000040

Gu Z, Fu J, Lin H, et al., 2020, Development of 3D bioprinting: From printing methods to biomedical applications. Asian J Pharm Sci, 15(5):529–557. https://doi.org/10.1016/j.ajps.2019.11.003

 

Decante G, Costa JB, Silva-Correia J, et al., 2021, Engineering bioinks for 3D bioprinting. Biofabrication, 13(3):032001. https://doi.org/10.1088/1758-5090/abec2c

He P, Zhao J, Zhang J, et al., 2018, Bioprinting of skin constructs for wound healing. Burns Trauma, 6:5. https://doi.org/10.1186/s41038-017-0104-x

Hakimi N, Cheng R, Leng L, et al., 2018, Handheld skin printer: In situ formation of planar biomaterials and tissues. Lab Chip, 18(10):1440–1451. https://doi.org/10.1039/c7lc01236e

Aljghami ME, Saboor S, Amini-Nik S, 2019, Emerging innovative wound dressings. Ann Biomed Eng, 47(3):659–675. https://doi.org/10.1007/s10439-018-02186-w

Wang X, Qi J, Zhang W, et al., 2021, 3D-printed antioxidant antibacterial carboxymethyl cellulose/epsilon-polylysine hydrogel promoted skin wound repair. Int J Biol Macromol, 187:91–104. https://doi.org/10.1016/j.ijbiomac.2021.07.115

Deng X, Gould M, Ali MA, 2022, A review of current advancements for wound healing: Biomaterial applications and medical devices. J Biomed Mater Res B Appl Biomater, 110(11):2542–2573. https://doi.org/10.1002/jbm.b.35086

Zhao H, Xu J, Yuan H, et al., 2022, 3D printing of artificial skin patches with bioactive and optically active polymer materials for anti-infection and augmenting wound repair. Mater Horiz, 9(1):342–349. https://doi.org/10.1039/d1mh00508a

Yang Z, Ren X, Liu Y, 2021, N-halamine modified ceria nanoparticles: Antibacterial response and accelerated wound healing application via a 3D printed scaffold. Compos Part B Eng, 227:109390. https://doi.org/10.1016/j.compositesb.2021.109390

He X, Yang S, Liu C, et al., 2020, Integrated wound recognition in bandages for intelligent treatment. Adv Healthc Mater, 9(22):e2000941. https://doi.org/10.1002/adhm.202000941

Wang C, Jiang X, Kim HJ, et al., 2022, Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing. Biomaterials, 285:121479. https://doi.org/10.1016/j.biomaterials.2022.121479

Lei Q, He D, Ding L, et al., 2022, Microneedle patches integrated with biomineralized melanin nanoparticles for simultaneous skin tumor photothermal therapy and wound healing. Adv Funct Mater, 32(22):2113269. https://doi.org/10.1002/adfm.202113269

Alizadehgiashi M, Nemr CR, Chekini M, et al., 2021, Multifunctional 3D-printed wound dressings. ACS Nano, 15(7):12375–12387. https://doi.org/10.1021/acsnano.1c04499

Cereceres S, Lan Z, Bryan L, et al., 2019, Bactericidal activity of 3D-printed hydrogel dressing loaded with gallium maltolate. APL Bioeng, 3(2):026102. https://doi.org/10.1063/1.5088801

Wu Z, Hong Y, 2019, Combination of the silver-ethylene interaction and 3D printing to develop antibacterial superporous hydrogels for wound management. ACS Appl Mater Interfaces, 11(37):33734–33747. https://doi.org/10.1021/acsami.9b14090

Yang Z, Ren X, Liu Y, 2021, Multifunctional 3D printed porous GelMA/xanthan gum based dressing with biofilm control and wound healing activity. Mater Sci Eng C Mater Biol Appl, 131:112493. https://doi.org/10.1016/j.msec.2021.112493

Krishnan KA, Thomas S, 2019, Recent advances on herb-derived constituents-incorporated wound-Dressing materials: A review. Polym Adv Technol, 30(4):823–838. https://doi.org/10.1002/pat.4540

Dhivya S, Padma VV, Santhini E, 2015, Wound dressings—A review. Biomedicine (Taipei), 5(4):22. https://doi.org/10.7603/s40681-015-0022-9

 

Zhu J, Jiang G, Song G, et al., 2019, Incorporation of ZnO/Bioactive glass nanoparticles into alginate/chitosan composite hydrogels for wound closure. ACS Appl Biol Mater, 2(11):5042–5052. https://doi.org/10.1021/acsabm.9b00727

Teoh JH, Mozhi A, Sunil V, et al., 2021, 3D printing personalized, photocrosslinkable hydrogel wound dressings for the treatment of thermal burns. Adv Funct Mater, 31(48):2105932. https://doi.org/10.1002/adfm.202105932

Vargas AJ, Harris CC, 2016, Biomarker development in the precision medicine era: Lung cancer as a case study. Nat Rev Cancer, 16(8):525–537. https://doi.org/10.1038/nrc.2016.56

Arnedos M, Vicier C, Loi S, et al., 2015, Precision medicine for metastatic breast cancer—Limitations and solutions. Nat Rev Clin Oncol, 12(12):693–704. https://doi.org/10.1038/nrclinonc.2015.123

Afghah F, Ullah M, Seyyed Monfared Zanjani J, et al., 2020, 3D printing of silver-doped polycaprolactone-poly(propylene succinate) composite scaffolds for skin tissue engineering. Biomed Mater, 15(3):035015. https://doi.org/10.1088/1748-605X/ab7417

Xia S, Weng T, Jin R, et al., 2022, Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds. Burns Trauma, 10:tkac001. https://doi.org/10.1093/burnst/tkac001

Li T, Ma H, Ma H, et al., 2019, Mussel-inspired nanostructures potentiate the immunomodulatory properties and angiogenesis of mesenchymal stem cells. ACS Appl Mater Interfaces, 11(19):17134–17146. https://doi.org/10.1021/acsami.8b22017

Ma H, Zhou Q, Chang J, et al., 2019, Grape seed-inspired smart hydrogel scaffolds for melanoma therapy and wound healing. ACS Nano, 13(4):4302–4311. https://doi.org/10.1021/acsnano.8b09496

Bergonzi C, Bianchera A, Remaggi G, et al., 2021, Biocompatible 3D printed chitosan-based scaffolds containing α-tocopherol showing antioxidant and antimicrobial activity. Appl Sci, 11(16):7253. https://doi.org/10.3390/app11167253

Ma C, Jiang L, Wang Y, et al., 2019, 3D printing of conductive tissue engineering scaffolds containing polypyrrole nanoparticles with different morphologies and concentrations. Materials (Basel), 12(15):2491. https://doi.org/10.3390/ma12152491

Xu J, Fang H, Su Y, et al., 2022, A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering. Int J Biol Macromol, 220:1253–1266. https://doi.org/10.1016/j.ijbiomac.2022.08.149

Chang P, Li S, Sun Q, et al., 2022, Large full-thickness wounded skin regeneration using 3D-printed elastic scaffold with minimal functional unit of skin. J Tissue Eng, 13:20417314211063022. https://doi.org/10.1177/20417314211063022

Elemoso A, Shalunov G, Balakhovsky YM, et al., 2020, 3D Bioprinting: The roller coaster ride to commercialization. Int J Bioprint, 6(3):301. https://doi.org/10.18063/ijb.v6i3.301

Zhang Y, Wang B, Hu J, et al., 2021, 3D composite bioprinting for fabrication of artificial biological tissues. Int J Bioprint, 7(1):299. https://doi.org/10.18063/ijb.v7i1.299

Kharaziha M, Baidya A, Annabi N, 2021, Rational design of immunomodulatory hydrogels for chronic wound healing. Adv Mater, 33(39):e2100176. https://doi.org/10.1002/adma.202100176

 

Wang Y, Niu W, Qu X, et al., 2022, Bioactive anti-inflammatory thermocatalytic nanometal-polyphenol polypeptide scaffolds for MRSA-infection/tumor postsurgical tissue repair. ACS Appl Mater Interfaces, 14(4):4946–4958. https://doi.org/10.1021/acsami.1c21082

Xi Y, Ge J, Wang M, et al., 2020, Bioactive anti-inflammatory, antibacterial, antioxidative silicon-based nanofibrous dressing enables cutaneous tumor photothermo-chemo therapy and infection-induced wound healing. ACS Nano, 14(3):2904–2916. https://doi.org/10.1021/acsnano.9b07173

Piola B, Sabbatini M, Gino S, et al., 2022, 3D bioprinting of gelatin-xanthan gum composite hydrogels for growth of human skin cells. Int J Mol Sci, 23(1):539. https://doi.org/10.3390/ijms23010539

 

Tsegay F, Elsherif M, Butt H, 2022, Smart 3D printed hydrogel skin wound bandages: A review. Polymers, 14(5):1012. https://doi.org/10.3390/polym14051012

Gopinathan J, Noh I, 2018, Recent trends in bioinks for 3D printing. Biomater Res, 22:11. https://doi.org/10.1186/s40824-018-0122-1

Dey M, Ozbolat IT, 2020, 3D bioprinting of cells, tissues and organs. Sci Rep, 10(1):14023. https://doi.org/10.1038/s41598-020-70086-y

Parak A, Pradeep P, Du Toit LC, et al., 2019, Functionalizing bioinks for 3D bioprinting applications. Drug Discov Today, 24(1):198–205. https://doi.org/10.1016/j.drudis.2018.09.012

Xie Z, Gao M, Lobo AO, et al., 2020, 3D bioprinting in tissue engineering for medical applications: The classic and the hybrid. Polymers, 12(8):1717. https://doi.org/10.3390/polym12081717

Agarwala S, 2016, A perspective on 3D bioprinting technology: Present and future. Am J Eng Appl Sci, 9(4):985–990. https://doi.org/10.3844/ajeassp.2016.985.990

Daikuara LY, Chen X, Yue Z, et al., 2021, 3D bioprinting constructs to facilitate skin regeneration. Adv Funct Mater, 32(3):2105080. https://doi.org/10.1002/adfm.202105080

Pati F, Gantelius J, Svahn HA, 2016, 3D bioprinting of tissue/ organ models. Angew Chem Int Ed Engl, 55(15):4650–4665. https://doi.org/10.1002/anie.201505062

Jang KS, Park SJ, Choi JJ, et al., 2021, Therapeutic efficacy of artificial skin produced by 3D bioprinting. Materials (Basel), 14(18):5177. https://doi.org/10.3390/ma14185177

Share
Back to top
International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing