A Study on Dual-Response Composite Hydrogels Based on Oriented Nanocellulose

¹ Macromolecular Platforms for Translational Medicine and Bio-Manufacturing Laboratory, Tsinghua-Berkeley Shenzhen Institute, Shenzhen 518055, P.R. China

² Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China

³ Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, P.R. China

⁴ Department of Mechanical Engineering, Drexel University, Philadelphia, PA, USA

IJB 2022, 8(3), 578 https://doi.org/10.18063/ijb.v8i3.578

Submitted: 26 March 2022 | Accepted: 21 April 2022 | Published: 8 June 2022

© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

In nature, many biological tissues are composed of oriented structures, which endow tissues with special properties and functions. Although traditional hydrogels can achieve a high level of biomimetic composition, the orderly arrangement of internal structures remains a challenge. Therefore, it is of great significance to synthesize hydrogels with oriented structures easily and quickly. In this study, we first proposed and demonstrated a fabrication process for producing a well-ordered and dual-responsive cellulose nanofibers + hyaluronic acid methacrylate (CN+HAMA) hydrogels through an extrusion-based three-dimensional (3D) printing process. CN in the CN+HAMA hydrogels are directionally aligned after extrusion due to shear stress. In addition, the synthesized hydrogels exhibited responsive behaviors to both temperature and ultraviolet light. Since the temperature-responsiveness is reversible, the hydrogels can transit between the gelation and solution states while retaining their original qualities. Furthermore, the developed well-oriented CN+HAMA hydrogels induced directional cell growth, paving the way for potential applications in ordered biological soft-tissue repair

Keywords

Nanocellulose hydrogel

Directional arrangement

Thermal response

Ultraviolet response

3D printing

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