AccScience Publishing / GTM / Volume 3 / Issue 2 / DOI: 10.36922/gtm.2208
Cite this article
108
Download
1547
Views
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
REVIEW

Mitochondrial involvement in ferroptotic cell death

Chayan Munshi1* Tithi Paul1,2 Kalpesh Jas1,2† Mihieka Bose1,2† Shelley Bhattacharya2
Show Less
1 Ethophilia Research Foundation, Santiniketan, India
2 Department of Zoology, Visva Bharati University, Santiniketan, India
Global Translational Medicine 2024, 3(2), 2208 https://doi.org/10.36922/gtm.2208
Submitted: 8 November 2023 | Accepted: 4 January 2024 | Published: 18 March 2024
© 2024 by the Author (s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Ferroptosis is a regulated cell death pathophysiologically associated with the depletion of the antioxidant system due to iron overload, which results in excess lipid peroxidation. Mitochondria are crucial organelles known for their prominent involvement in various cellular metabolic activities and cell death processes. While our understanding of ferroptotic signaling pathways is advancing, further investigation into the intricate relationship between mitochondrial bio-process and this mode of cell death is necessary to identify effective biomedical therapeutic options targeting this organelle. However, the direct involvement of mitochondria in ferroptosis has remained a topic of debate due to the limited availability of concrete information to date. This review aims to elucidate the pathophysiological perspectives of mitochondria during ferroptotic cell death.

Keywords
Ferroptosis
Mitochondria
Cell death
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
References
  1. Munshi C, Bhattacharya S. The Ironyof Ferroptosis: A Review on Neurological Challenges. London, UK: IntechOpen; 2022.

 

  1. Chen X, Yu C, Kang R, Tang D. Iron metabolism in ferroptosis. Front Cell Dev Biol. 2020;8:590226. doi: 10.3389/fcell.2020.590226

 

  1. Mukherjee S, Munshi C. A Mechanistic Discussion on Oxidative Stress and Ferroptosis. Preprints; 2023.

 

  1. Wang H, Liu C, Zhao Y, Gao G. Mitochondria regulation in ferroptosis. Eur J Cell Biol. 2020;99(1):151058. doi: 10.1016/j.ejcb.2019.151058

 

  1. Chen X, Kang R, Kroemer G, Tang D. Organelle-specific regulation of ferroptosis. Cell Death Differ. 2021;28(10):2843-2856. doi: 10.1038/s41418-021-00859-z

 

  1. Bae YS, Oh H, Rhee SG, Yoo YD. Regulation of reactive oxygen species generation in cell signaling. Mol Cells. 2011;32(6):491-509. doi: 10.1007/s10059-011-0276-3

 

  1. Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol. 2021;220(9):e202105043. doi: 10.1083/jcb.202105043

 

  1. Javadov S. Mitochondria and ferroptosis. Curr Opin Physiol. 2022;25:100483. doi: 10.1016/j.cophys.2022.100483

 

  1. Li J, Jia YC, Ding YX, Bai J, Cao F, Li F. The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks. Int J Biol Sci. 2023;19(9):2756-2771. doi: 10.7150/ijbs.83348

 

  1. Takashi Y, Tomita K, Kuwahara Y, et al. Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis. Free Radic Biol Med. 2020;161:60-70. doi: 10.1016/j.freeradbiomed.2020.09.027

 

  1. Conrad M, Da Silva MC. Ferroptosis: Physiological and pathophysiological aspects. In: Oxidative Stress. Academic Press; 2020. p. 149-166.

 

  1. Jelinek A, Heyder L, Daude M, et al. Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis. Free Radic Biol Med. 2018;117:45-57. doi: 10.1016/j.freeradbiomed.2018.01.019

 

  1. Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z. Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway. Free Radic Biol Med. 2022;180:95-107. doi: 10.1016/j.freeradbiomed.2022.01.012

 

  1. Gao M, Yi J, Zhu J, et al. Role of mitochondria in ferroptosis. Mol Cell. 2019;73(2):354-363.e3. doi: 10.1016/j.molcel.2018.10.042

 

  1. Yao X, Li W, Fang D, et al. Emerging roles of energy metabolism in ferroptosis regulation of tumor cells. Adv Sci (Weinh). 2021;8(22):e2100997. doi: 10.1002/advs.202100997

 

  1. Krabbendam IE, Honrath B, Dilberger B, et al. SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis. 2020;11(4):263. doi: 10.1038/s41419-020-2458-4

 

  1. Oh SJ, Ikeda M, Ide T, Hur KY, Lee MS. Mitochondrial event as an ultimate step in ferroptosis. Cell Death Discov. 2022;8(1):414. doi: 10.1038/s41420-022-01199-8

 

  1. Otasevic V, Vucetic M, Grigorov I, Martinovic V, Stancic A. Ferroptosis in different pathological contexts seen through the eyes of mitochondria. Oxid Med Cell Longev. 2021;2021:5537330. doi: 10.1155/2021/5537330

 

  1. Wang L, Ouyang S, Li B, Wu H, Wang F. GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis. Cell Death Discov. 2021;7(1):334. doi: 10.1038/s41420-021-00726-3

 

  1. Basit F, Van Oppen LM, Schöckel L, et al. Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 2017;8(3):e2716. doi: 10.1038/cddis.2017.133

 

  1. Nakamura T, Ogawa M, Kojima K, et al. The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis. EMBO Rep. 2021;22(5):e51532. doi: 10.15252/embr.202051532

 

  1. Wu C, Zhao W, Yu J, Li S, Lin L, Chen X. Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells. Sci Rep. 2018;8(1):574. doi: 10.1038/s41598-017-18935-1

 

  1. Tang Q, Chen H, Mai Z, et al. Bim-and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis. Free Radic Biol Med. 2022;180:198-209. doi: 10.1016/j.freeradbiomed.2022.01.013

 

  1. Xie Y, Hou W, Song X, et al. Ferroptosis: Process and function. Cell Death Differ. 2016;23(3):369-379. doi: 10.1038/cdd.2015.158

 

  1. Li C, Liu J, Hou W, Kang R, Tang D. STING1 promotes ferroptosis through MFN1/2-dependent mitochondrial fusion. Front Cell Dev Biol. 2021;9:698679. doi: 10.3389/fcell.2021.698679

 

  1. Wu H, Wang F, Ta N, Zhang T, Gao W. The multifaceted regulation of mitochondria in ferroptosis. Life (Basel). 2021;11(3):222. doi: 10.3390/life11030222
Share
Back to top
Global Translational Medicine, Electronic ISSN: 2811-0021 Published by AccScience Publishing