AccScience Publishing / AN / Volume 1 / Issue 2 / DOI: 10.36922/an.v1i2.83
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Neurological complications of coronavirus disease 2019 and the underlying mechanisms

Zhiyuan Yang1 Chenglu Mao1 Qiaochu Guan2 Weiping Lv3 Yanan Huang3 Huahong Zhu4 Yun Xu1,5,6,7*
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1 Department of Neurology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China
2 Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China
3 Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China
4 Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China
5 The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
6 Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
7 Jiangsu Province Stroke Center for Diagnosis and Therapy, China Nanjing Neurology Clinic Medical Center, Nanjing, China
Advanced Neurology 2022, 1(2), 83
Submitted: 5 May 2022 | Accepted: 7 July 2022 | Published: 18 August 2022
© 2022 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

The recent global pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although respiratory symptoms are the primary manifestation of the majority of COVID-19 patients, an increasing number of neurological symptoms and manifestations of COVID-19 have been observed. In this review, we detail the neurological complications of COVID-19, such as gustatory and olfactory dysfunctions, stroke, memory decline, muscle injury, and seizures. Furthermore, we introduce neural invasion mechanism underlying SARS-CoV-2 infection and, further, explain the occurrence of these complications. This review offers insights into the neurological signs and symptoms of COVID-19, which may help improve the prognosis of the infected patients.

Neurological complications
Clinic characteristics
Neural invasion
National Natural Science Foundation of China
Key Research and Development Program of Jiangsu Province of China

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Conflict of interest
The authors have no competing interest to declare.
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Advanced Neurology, Electronic ISSN: 2810-9619 Published by AccScience Publishing