Chronic kidney disease (CKD) is a progressive and debilitating condition that poses a significant health burden globally. As a silent disease that often goes undetected until advanced stages, CKD affects millions of individuals and has far-reaching implications on public health. The prevalence of CKD continues to rise, driven by factors such as aging populations, increasing rates of diabetes and hypertension, and lifestyle changes. Autoimmune mechanisms also play very significant role in the pathogenesis of CKD, particularly in conditions such as systemic lupus erythematosus (SLE), vasculitis, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. In these autoimmune diseases, abnormal immune responses result in inflammation and damage to the kidneys, leading to glomerulonephritis and eventual kidney dysfunction. Given the insidious nature of CKD and its potential to lead to end-stage renal disease (ESRD) and other serious complications, there is an urgent need to enhance our diagnostic and therapeutic approaches to better manage this condition. Continued research into the immunological basis of CKD and autoimmune disorders holds promise for advancing personalized approaches to kidney care and improving the long-term outcomes of patients affected by these complex conditions.

To this end, we sincerely invite researchers to contribute their research works to this Special Issue, entitled " Chronic Kidney Diseases: Novel Diagnostic and Therapeutic Approaches ", which aims to provide a research platform for the collection of original research articles and the latest reviews which cover all aspects of the pathogenesis of chronic kidney diseases. Potential topics include, but are not limited to, the following:

- Novel biomarkers and therapeutic targets for the diagnosis and treatment of chronic kidney disease and/ or glomerunephritis.

- Genetic factors, inflammatory or other pathogenic pathways responsible for the onset of CKD under various pathological diseases.

- Clinical trials and clinical case studies for chronic kidney diseases .

- Genetic or spontaneously induced animal models for CKD or glomerunephritis.

- Protocols, reviews, systematic reviews and meta-analyses, mechanistic papers.