AccScience Publishing / ITPS / Volume 2 / Issue 1 / DOI: 10.26689/itps.v2i1.436
Cite this article
25
Download
743
Views
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
MINI-REVIEW

A Review on Leucas aspera for Phytopharmacological Studies

Enjamoori Vijay Kumar1 Nampalli Avinash1 Vasudha Bakshi1 Gangarapu Kiran1 Boggula Narender1
Show Less
1 Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Telangana, India
INNOSC Theranostics and Pharmacological Sciences 2019, 2(1), 436 https://doi.org/10.26689/itps.v2i1.436
Submitted: 7 November 2018 | Accepted: 24 November 2018 | Published: 27 December 2018
© 2018 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

 Herbal medicine is one of the oldest valuable bestowals that was given to mankind. Many plants and herbs hold their 
prestigious position in the field of medicine. Plants are being used from more than 1000 years to treat diseases. The healing 
properties of plants have been transferred within the human communities for over the centuries. Leucas aspera Linn. most 
commonly known as “Thumbai,” “Gumma,” and “Thummichittu” and widely distributed in all parts of India. Conventionally, 
it is also used as an anti-pyretic and insecticide. It also possesses medicinal properties such as antimicrobial, larvicidal, antinociceptive, cytotoxic antioxidant, and hepatoprotective activity. The leaves of Leucas are used in rheumatism. Various 
phytochemical constituents are present in all parts of the plant mainly terpenoids, fatty acids, nicotine, ursolic acid, glucoside, beta-sitosterol, sterols, diterpene, and phenolic compounds. L. aspera possesses many medicinally active phytocompounds and has various biological and pharmacological effects, and hence this plant could have the constituents as new therapeutic agents.

Keywords
Leucas aspera
antioxidant
anti-nociceptive
cytotoxic activity
larvicidal activity
References
[1]

Kumar, G.V.; Devanna, N. An update of Leucas aspera-a medicinal plant. Int. J. Sci. Res. Methodol., 2016, 5(1), 485-503.

[2]

Srivastava, J.; Lambert, J.; Vietmeyer, N. Medicinal Plants: An Expanding Role in Development. World Bank Technical Paper; 1996. p. 320.

[3]

Sabri, G.; Vimala, Y.; Mandlik, P. Leucas aspera: Medicinal plant review. Int. Res. J. Multidiscip. Stud., 2015, 1(3), 1-8.

[4]

Srinivasan, R.; Ravali, B.; Suvarchala, P.; Honey, A.; Tejaswini, A.; Neeraja, P. Leucas aspera-medicinal plant: A review. Int. J. Pharm. Bio Sci., 2011, 2(2), 153-159.

[5]

Prajapati, M.S.; Patel, J.B.; Modi, K.; Shah, M.B. Leucas aspera: A review. Pharmacogn. Rev., 2010, 4(7), 85-87.

[6]

Khare, C.P. Encyclopedia of Indian Medicinal Plants. New York: Springer; 2007.

[7]

Rai, V.; Agarwal, M.; Agnihotri, A.K.; Khatoon, S.; Rawat, A.K.; Mehrotra, S. Pharmacognostical evaluation of Leucas aspera. Nat. Prod. Sci., 2005, 11, 109-114.

[8]

Nadkarni, K.M. Indian Materia Medica. Mumbai: Popular Prakashan; 1976. p. 739.

[9]

Shirazi, A.M. Studies on Leucas aspera. Indian J. Pharm., 1947, 9, 116-117.

[10]

Trease, G.E.; Evans, W.C. A taxonomic approach to the study of medicinal plants and animal derived drugs. In: Trease and Evans Pharmacognosy. Singapore: Harcourt Brace and Company Asia Pvt. Ltd.; 2002.

[11]

Kirtikar, K.R.; Basu, B.D. Indian Medicinal Plants. New Delhi: Periodical Experts; 1975. p. 2019-2020.

[12]

Nadkarni, K.M. Indian Materia Medica. Mumbai: Popular Prakashan; 1976. p. 739.

[13]

Saritha, K.; Rajesh, A.; Manjulatha, K.; Setty, O.H.; Yenugu, S. Mechanism of antibacterial action of the alcoholic extracts of Hemidesmus indicus (L.) R. Br. ex Schult, Leucas aspera (Wild.), Plumbago zeylanica L., and Tridax procumbens (L.) R. Br. ex Schult. Front. Microbiol., 2015, 6, 577.

[14]

Mangathayaru, K.; Thirumurugan, D.; Patel, P.S.; Pratap, D.V.; David, D.J.; Karthikeyan, J. Isolation and identification of nicotine from Leucas aspera (willd). Indian J. Pharm. Sci., 2006, 68, 88-90.

[15]

Khaleque, A.; Huq, M.E.; Huq, M.S.; Mansoor, M.H. Chemical investigations on Leucas aspera. I. Isolation of compound-A, 3-sitosterol and et-sitosterol from the aerial parts. Sci. Res., 1970, 7, 125-137.

[16]

Chatterjee, S.K.; Majumdar, D.N. Chemical investigation of Leucas aspera. J. Inst. Chem., 1969, 41, 98-101.

[17]

Sadhu, S.K.; Okuyama, E.; Fujimoto, H.; Ishibashi, M. Diterpenes from Leucas aspera inhibiting prostaglandin-induced contractions. J. Nat. Prod., 2006, 69, 988-994.

[18]

Sadhu, S.K.; Okuyama, E.; Fujimoto, H.; Ishibashi, M. Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities. Chem. Pharm. Bull. (Tokyo)., 2003, 51, 595-598.

[19]

Kalachaveedu, M.; Ghosh, A.; Ranjan, R.; VedamVenkat, K. Volatile constituents of Leucas aspera (WilId.). J. Essent. Oil Res., 2006, 18, 104-105.

[20]

Jam, M.P.; Nath, H.B. Examination of the component fatty acids of the oil from the seeds of Leucas aspera. Lab. Dev., 1968, 6, 34-36.

[21]

Badami, R.C.; Patil, K.B. Minor seed oils. X: Physico-chemical characteristics and fatty acid composition of seven minor oils. J. Oil Technol. Assoc. India, 1975, 7, 82-84.

[22]

Misra, T.N.; Singh, R.S.; Pandey, H.S.; Singh, S. A novel phenolic compound from Leucas aspera Spreng. Indian J. Chem. Br., 1995, 34, 1108-1110.

[23]

Misra, T.N.; Singh, R.S.; Prasad, C.; Singh, S. Two aliphatic ketols from Leucas aspera. Phytochemistry, 1992, 32, 199-201.

[24]

Misra, T.N.; Singh, R.S.; Pandey, H.S.; Singh, S. Long-chain compounds from Leucas aspera. Phytochemistry, 1992, 31, 1809-1810.

[25]

Pradhan, B.; Chakraborty, D.; Subba, G. A triterpenoid lactone from Leucas aspera. Phytochemistry, 1990, 29, 1693-1695.

[26]

Maheswaran, R.; Sathish, S.; Ignacimuthu, S. Larvicidal activity of Leucas aspera (Willd.) against the larvae of Culex quinquefasciatus Say. and Aedes aegypti L. Int. J. Integr. Biol., 2008, 2(3), 214-217.

[27]

Thakur, D.K.; Misra, S.K.; Choudhuri, P.C. In vitro trials of plant extracts and chemicals for their antifungal activity. Indian J. Anim. Health, 1987, 26, 31-35.

[28]

Hossan, A.N.; Zaman, F.; Barman, M.R.; Khatoon, S.; Zaman, M.; Khatun, F.; Mosaiab, T.; Mostafa, F.; Sintaha, M.; Jamal, F.; Rahmatullah, M. Antinociceptive activity of Xanthium indicum J. Koenig ex Roxb. (Asteraceae) leaves and Leucas aspera (Willd.) Link (Lamiaceae) whole plants. Adv. Nat. Appl. Sci., 2011, 5(2), 214-217.

[29]

Mannan, A.; Das, H.; Rahman, M.; Jesmin, J.; Siddika, A.; Rahman, M.; Rahman, S.; Chowdhury, M.H.; Rahmatullah, M. Antihyperglycemic activity evaluation of Leucas aspera (Willd.) link leaf and stem and Lannea coromandelica (Houtt.) Merr. bark extract in mice. Adv. Nat. Appl. Sci., 2010, 4(3), 385-388.

[30]

Mangathayaru, K.; Grace, X.F.; Bhavani, M.; Meignanam, E.; Karna, S.L.; Kumar, D.P. Effect of Leucas aspera on hepatotoxicity in rats. Indian J. Pharmacol., 2005, 37(5), 329-330.

[31]

Annapandian, V.M.; Rajagopal, S.S. Phytochemical evaluation and in vitro anti-oxidant activity of various solvent extracts of Leucas aspera (Willd.) Link leaves. Free Radic. Antioxid., 2017, 7(2), 166-171.

[32]

Gangadharan, A.; Jacob, E.; Jose, D. Phytochemical analysis, antibacterial and anti hyaluronidase activity of three indigenous medicinal plants. World J. Pharm. Pharm. Sci., 2014, 3(6), 751-761.

[33]

Augustine, B.B.; Pitta, S.; Lahkar, M.; Suvakanta, D.; Samudrala, P.K.; Thomas, J.M. Ulcer protective effect of Leucas aspera in various experimental ulcer models. Asian Pac. J. Trop. Dis., 2014, 4(1), S395-S402.

[34]

Kavitha, R.; Kannan, R.; Glory, J.I. Selected neuro behavioural evaluation of Leucas aspera in wister albino rats. Int. J. Basic Clin. Pharmacol., 2013, 2(4), 433-437.

[35]

Thenmozhi, M.; Dhanalakshmi, M.; Devi, K.M. Evaluation of hepatoprotective activity of Leucas aspera hydroalcoholic leaf extract during exposure to lead acetate in male albino Wistar rats. Asian J. Pharm. Clin. Res., 2013. 6(1), 78-81.

[36]

Shelke, S.; Sreedhar, C.; Chandrasekhar, K.B. Analgesic activity of Leucas aspera and Cassia tora roots. Indo Am. J. Pharm. Res., 2015, 5(01), 333-337.

[37]

Kripa, K.G.; Chamundeeswari, D.; Thanka, J.; Reddy, C.U.M. Effect of hydroalcoholic extract of aerial parts of Leucas aspera (Willd.) link on inflammatory markers in complete freund’s adjuvant induced arthritic rats. Int. J. Green Pharm., 2010, 4(4), 281-287.

[38]

Ali, M.S.; Sayeed, M.A.; Nabi, M.M.; Rahman, M.A.A. In vitro antioxidant and cytotoxic activities of methanol extract of Leucas aspera leaves. J. Pharmacogn. Phytochem., 2013, 2(1), 8-13.

[39]

Gupta, N.; Agarwal, M.; Bhatia, V.; Sharma, R.K.; Narang, E. A comparative antidiabetic and hypoglycaemic activity of the crude alcoholic extracts of the plant Leucas aspera and seeds of Pithecellobium bigeminum in rats. Int. J. Res. Ayurveda Pharm., 2011, 2(1), 275-280.

[40]

Manonmani, S.; Madhavan, R.; Shanmugapriya, P.; Manjari, V.; Murugesan, S.; Banumathi, V. A review of beneficial effects of siddha medicinal herbs on snake bite. Int. J. Curr. Res. Biol. Med., 2016, 1(7), 27-35.

[41]

Agarwal, S.; Jacob, S.; Bisoyi, S.; Badarinath, D.K.; Vedamurthy, A.B.; Krishna, V.; Hoskeri, H.J. Evaluation of in vitro anthelminthic activity of Leucas aspera extracts. Pharmacog. J., 2011, 3(24), 77-80.

[42]

Rahman, S.; Sarder, M.; Ali, Y.; Rashid, A. Central nervous system depressant activity of Leucas aspera root. Orient. Pharm. Exp. Med., 2006, 6(3), 174-178.

Conflict of interest
The authors declare no conflict of interest in any kind.
Share
Back to top
INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing