Injuries and diseases of the musculoskeletal system are among the most prevalent and expensive clinical conditions, resulting in a huge socioeconomic impact worldwide. Massive bone defects, articular cartilage degeneration, and irreparable meniscal injuries are just some of the musculoskeletal disorders that currently lack a definitive and consensual treatment and remain one of the main challenges for the healthcare system. In this scenario, tissue engineering and regenerative medicine strategies emerge as a potential alternative for developing an effective and innovative therapy. Bioprinting has already demonstrated a prominent role in this future and has gained the attention of many researchers.

Thus, this special issue is oriented to the advances and applications of 3D bioprinting technology in the treatment of disorders that affect tissues of the human locomotor system. Special attention will be given, but not limited to, the fabrication of scaffolds and regenerative implants for tissue repair, as well as the development of models to better understand the pathophysiology of the disease and test novel drugs.