AccScience Publishing / IJB / Volume 9 / Issue 4 / DOI: 10.18063/ijb.716
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Hybrid solid mesh structure for electron beam melting customized implant to treat bone cancer

Jong Woong Park1,2,3† Eunhyeok Seo4† Haeum Park5 Ye Chan Shin2 Hyun Guy Kang1 Hyokyung Sung6* Im Doo Jung4*
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1 Orthopaedic Oncology Clinic, Center for Rare Cancers, National Cancer Center, Goyang 10408, Republic of Korea
2 Surgical Oncology Branch, Division of Clinical Research, National Cancer Center, Goyang 10408, Republic of Korea
3 Department of Cancer Control and Population Health, NCC-Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea
4 Department of Mechanical Engineering, Ulsan National Institute of Science and Technology, UNIST-gil 50, Ulsan, 44919, Republic of Korea
5 Department of 3D Printing Materials, Korea Institute of Materials Science, Changwon, 51508, Republic of Korea
6 Department of Materials Science and Engineering, Kookmin University, Seoul 02707, Republic of Korea
(This article belongs to the Special Issue Laser bioprinting technologies)
© Invalid date by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Bone replacement implants manufactured by electron beam melting have been widely studied for use in bone tumor treatment. In this application, a hybrid structure implant with a combination of solid and lattice structures guarantees strong adhesion between bone and soft tissues. This hybrid implant must exhibit adequate mechanical performance so as to satisfy the safety criteria considering repeated weight loading during the patient’s lifetime. With a low volume of a clinical case, various shape and volume combinations, including both solid and lattice structures, should be evaluated to provide guidelines for implant design. This study examined the mechanical performance of the hybrid lattice by investigating two shapes of the hybrid implant and volume fractions of the solid and lattice structures, along with microstructural, mechanical, and computational analyses. These results demonstrate how hybrid implants may be designed to improve clinical outcomes by using patientspecific orthopedic implants with optimized volume fraction of the lattice structure, allowing for effective enhancement of mechanical performance as well as optimized design for bone cell ingrowth.

3D printing
Bone cancer
Titanium alloy implant
Electron beam melting
Fracture analysis

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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing