Revealing emerging science and technology research for dentistry applications of 3D bioprinting
Science and technology (S&T) on three-dimensional (3D) bioprinting is growing at an increasingly accelerated pace; one major challenge represents how to develop new solutions for frequent oral diseases such as periodontal problems and loss of alveolar bone. 3D bioprinting is expected to revolutionize the health industry in the upcoming years. In dentistry, this technology can become a significant contributor. This study applies a Competitive Technology Intelligence methodology to uncover the main S&T drivers in this domain. Looking at a 6-year period from 2012 to 2018 an analysis of scientific and technology production was made. Three principal S&T drivers were identified: Scaffolds development, analysis of natural and synthetic materials, and the study of scaffold characteristics. Innovative hybrid and multiphasic scaffolds are being developed to regenerate periodontal tissue and alveolar bone by combining them with stem cells from the pulp or periodontal ligament. To improve scaffolds performance, biodegradable synthetic polymers are often used in combination with bioceramics. The characteristics of scaffolds such as fiber orientation, porosity, and geometry, were also investigated. This research contributes to people interested in bringing innovative solutions to the health industry, particularly by applying state-of-the-art technologies such as 3D bioprinting, in this case for dental tissues and dental bone diseases.
1. Rodríguez-Salvador M, Rio-Belver RM, Garechana- Anacabe G, 2017, Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting. PLoS One, 12(6): e0180375. https://doi.org/10.1371/journal.pone.0180375.
2. Trappey A J, Trappey C V, Lee K L, 2017, Tracing the evolution of biomedical 3d printing technology using ontology-based patent concept analysis. Technol Anal Strateg Manag, 29: 339- 352. https://doi.org/10.1080/09537325.2016.1211267.
3. Comb J W, Priedeman W R, Turley P W, 1994, FDM technology process improvements. Solid Free Fabr Proc, 11, 42-49.
4. Kruth J P, Wang X, Laoui T, et al., 2003, Lasers and materials in selective laser sintering. Assem Autom, 23: 357-371. https://doi.org/10.1108/01445150310698652.
5. Murr L E, Gaytan S M, Ramirez D A, et al., 2012, Metal fabrication by additive manufacturing using laser and electron beam melting technologies. J Mater Sci Technol, 28: 1-14. https://doi.org/https://doi.org/10.1016/S1005-0302(12)60016-4.
6. Derby B, 2010, Inkjet printing of functional and structural materials: Fluid property requirements, feature stability, and resolution. Annu Rev Mater Res, 40: 395-414. https://doi. org/10.1146/annurev-matsci-070909-104502.
7. Valkenaers H, Vogeler F, Ferraris E, et al., 2013, A Novel Approach to Additive Manufacturing: Screw Extrusion 3D-Printing. 10th International Conference on Multi-Material Micro Manufacture.
8. Guillemot F, Souquet A, Catros S, et al., 2010, Laser-assisted cell printing: principle, physical parameters versus cell fate and perspectives in tissue engineering. Nanomedicine, 5: 507-515. https://doi.org/10.2217/nnm.10.14.
9. Rengier F, Mehndiratta A, von Tengg-Kobligk H, et al., 2010, 3D printing based on imaging data: Review of medical applications. Int J Comput Assist Radiol Surg, 5: 335-41. https://doi.org/10.1007/s11548-010-0476-x.
10. Murphy S V., Atala A, 2014, 3D bioprinting of tissues and organs. Nat Biotechnol, 32(8): 773-785. https://doi: 10.1038/nbt.2958.
11. Tasoglu S, Demirci U, 2013, Bioprinting for stem cell research. Trends Biotechnol, 31: 10-19. https://doi.org/ https://doi.org/10.1016/j.tibtech.2012.10.005.
12. Albritton J L, Miller J S, 2017, 3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments. Dis Model Mech, 10: 3-14. https://doi. org/10.1242/dmm.025049.
13. Chang R, Nam J, Sun W, 2008, Direct cell writing of 3D microorgan for in vitro pharmacokinetic model. Tissue Eng Part C Methods, 14: 157-166. https://doi.org/10.1089/ten. tec.2007.0392.
14. Mandrycky C, Wang Z, Kim K, et al., 2016, 3D bioprinting for engineering complex tissues. Biotechnol Adv, 34(4): 422- 434. https://doi.org/10.1016/j.biotechadv.2015.12.011.
15. Melchels F P, Domingos M A, Klein T J, et al., 2012, Additive manufacturing of tissues and organs. Prog Polym Sci, 37: 1079-1104. https://doi.org/https://doi.org/10.1016/j. progpolymsci.2011.11.007.
16. Wilson W C, Boland T, 2003, Cell and organ printing 1: Protein and cell printers. Anat Rec Part A, 272A(2): 491-496. https://doi:10.1002/ar.a.10057.
17. Ingber D E, Mow V C, Butler D, et al., 2006, Tissue engineering and developmental biology: Going biomimetic. Tissue Eng, 12: 3265-3283. https://doi.org/10.1089/ ten.2006.12.3265.
18. Shu A F, 2015, Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D. Biofabrication, 7: 44102.
19. Seol Y J, Kang H W, Lee S J, et al., 2014, Bioprinting technology and its applications. Eur J Cardio Thoracic Surgm, 46: 342-348.
20. Derby B, 2008, Bioprinting: Inkjet printing proteins and hybrid cell-containing materials and structures. J Mater Chem, 18: 5717-5721. https://doi.org/10.1039/B807560C.
21. Cui X, Boland T, 2009, Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials, 30: 6221-6227. https://doi.org/10.1016/j. biomaterials.2009.07.056.
22. Ringeisen B R, Kim H, Barron JA, et al., 2004, Laser printing of pluripotent embryonal carcinoma cells. Tissue Eng, 10: 483-491. https://doi.org/10.1089/107632704323061843.
23. Fedorovich N E, Alblas J, de Wijn J R, et al., 2007, Hydrogels as extracellular matrices for skeletal tissue engineering: State-of-the-art and novel application in organ printing. Tissue Eng, 13: 1905-1925. https://doi.org/10.1089/ten.2006.0175.
24. Malda J, Visser J, Melchels F P, et al., 2013, 25th anniversary article: Engineering hydrogels for biofabrication. Adv Mater, 25: 5011-5028. https://doi.org/10.1002/adma.201302042.
25. Domingos M, Dinucci D, Cometa S, et al., 2009, Polycaprolactone scaffolds fabricated via bioextrusion for tissue engineering applications. Int J Biomater, 2009: 9. https://doi.org/10.1155/2009/239643.
26. Rutz A L, Hyland K E, Jakus A E, et al., 2015, A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels. Adv Mater, 27: 1607-1614. https://doi. org/10.1002/adma.201405076.
27. Kirchmajer D M, Gorkin I I, Panhuis M, 2015, An overview of the suitability of hydrogel-forming polymers for extrusion-based 3D-printing. J Mater Chem B, 3: 4105-4117. https:// doi.org/10.1039/C5TB00393H.
28. Drury J L, Mooney D J, 2003, Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials, 24: 4337-4351. https://doi.org/10.1016/S0142- 9612(03)00340-5.
29. Chimene D, Lennox K K, Kaunas R R, et al., 2016, Advanced bioinks for 3D printing: A materials science perspective. Ann Biomed Eng, 44: 2090-2102. https://doi.org/10.1007/s10439-016-1638-y.
30. Sears N A, Seshadri D R, Dhavalikar P S, et al., 2016, A review of three-dimensional printing in tissue engineering. Tissue Eng Part B Rev, 22: 298-310. https://doi.org/10.1089/ ten.teb.2015.0464.
31. Do A V, Khorsand B, Geary SM, et al., 2015, 3D printing of scaffolds for tissue regeneration applications. Adv Healthc Mater, 4: 1742-1762. https://doi.org/10.1002/adhm.201500168.
32. Sharma S, Srivastava D, Grover S, et al., 2014, Biomaterials in tooth tissue engineering: A review. J Clin Diagn Res, 8: 309-315. https://doi.org/10.7860/JCDR/2014/7609.3937.
33. Asaad F, Pagni G, Pilipchuk S P, et al., 2016, 3D-printed scaffolds and biomaterials: Review of alveolar bone augmentation and periodontal regeneration applications. Int. J. Dent, 2016: 15. 10.1155/2016/1239842.
34. Rasperini G, Pilipchuk S P, Flanagan C L, et al., 2015, 3D-printed bioresorbable scaffold for periodontal repair. J Dent Res, 94: 153S-157S. https://doi. org/10.1177/0022034515588303.
35. Costa P F, Vaquette C, Zhang Q, et al., 2013, Advanced tissue engineering scaffold design for regeneration of the complex hierarchical periodontal structure. J Clin Periodontol, 41: 283-294. https://doi.org/10.1111/jcpe.12214.
36. Lee C H, Hajibandeh J, Suzuki T, et al., 2014, Three-dimensional printed multiphase scaffolds for regeneration of periodontium complex. Tissue Eng Part A, 20: 1342-1351. https://doi.org/10.1089/ten.tea.2013.0386.
37. Ma Y, Ji Y, Huang G, et al., 2015, Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cell response to extracellular matrix Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cell response to extracellular ma. Biofabrication, 7: 044105.
38. Kim S, Chang N, Park S, 2018, In vivo evaluation of 3D-printed polycaprolactone scaffold implantation combined with β -TCP powder for alveolar bone augmentation in a beagle defect model. Materials, 11: 2. https://doi.org/10.3390/ma11020238.
39. Bencherif S A, Braschler T M, Renaud P, 2013, Advances in the design of macroporous polymer scaffolds for potential applications in dentistry. J Periodontal Implant Sci, 43: 251- 261. https://doi.org/10.5051/jpis.2013.43.6.251.