AccScience Publishing / IJB / Volume 1 / Issue 1 / DOI: 10.18063/IJB.2015.01.001
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REVIEW

The trend towards in vivo bioprinting

Manyi Wang1 ,  Jiankang He1* ,  Yaxiong Liu1 ,  Meng Li2 ,  Dichen Li1 ,  Zhongmin Jin1,3
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1 State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an, 710054, China
2 The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China
3 Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
IJB 2015, 1(1), 15–26; https://doi.org/10.18063/IJB.2015.01.001
© Invalid date by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Bioprinting is one of several newly emerged tissue engineering strategies that hold great promise in alleviating of organ shortage crisis. To date, a range of living biological constructs have already been fabricated in vitro using this technology. However, an in vitro approach may have several intrinsic limitations regarding its clinical applicability in some cases. A possible solution is in vivo bioprinting, in which the de novo tissues/organs are to be directly fabricated and positioned at the damaged site in the living body. This strategy would be particularly effective in the treatment of tissues/organs that can be safely arrested and immobilized during bioprinting. Proof-of-concept studies on in vivo bioprinting have been reported recently, on the basis of which this paper reviews the current state-of-the-art bioprinting technologies with a particular focus on their advantages and challenges for the in vivo application.

Keywords
bioprinting
in vivo
tissue engineering
regenerative medicine
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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