Burden and temporal trends of cutaneous melanoma in China, 1990–2023, with projections to 2033: A systematic analysis of the Global Burden of Disease Study 2023
Cutaneous melanoma poses an evolving public-health challenge in China, with an epidemiological profile distinct from that of Western populations. Using data from the Global Burden of Disease Study 2023, we assessed the burden of malignant skin melanoma in China from 1990 to 2023, including prevalence, incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs), and applied joinpoint regression, an intrinsic-estimator age–period–cohort (APC) model, and autoregressive integrated moving average (ARIMA) forecasting to 2033. Age-standardized prevalence rose from 1.39 (95% uncertainty interval [UI]: 0.82, 2.15) to 5.03 (95% UI: 3.17, 8.48) per 100,000; sex-specific prevalence rose approximately 3.38-fold in males and 2.13-fold in females, whereas mortality fell from 0.33 to 0.27 per 100,000 despite rising incidence. Period effects showed the largest variation (1.32 units for males, 0.97 for females), exceeding cohort and age effects and indicating contemporaneous factors as the principal drivers. Joinpoint analysis revealed acceleration after 2013 in males (APC 1.32% → 2.93%) and four phases in females. Sex patterns reversed by 2023, with males showing higher mortality (ratio 1.08) and DALYs (ratio 1.23), while the mortality-to-incidence ratio approximately halved in both sexes. ARIMA projected continued mortality decline (37.0% overall) through 2033, with wide long-term uncertainty. Melanoma burden in China has been transformed—markedly higher prevalence alongside falling mortality—driven predominantly by period rather than demographic effects. Interpreted in light of the acral lentiginous subtype prevalent in Chinese patients, these findings support population-specific prevention and early-detection strategies beyond ultraviolet-based paradigms.
- Arnold M, Singh D, Laversanne M, et al. Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040. JAMA Dermatol. 2022;158(5):495-503. doi:10.1001/jamadermatol.2022.0160
- Guy GP Jr, Thomas CC, Thompson T, et al. Vital signs: melanoma incidence and mortality trends and projections - United States, 1982-2030. MMWR Morb Mortal Wkly Rep. 2015;64(21):591-596.
- Chi Z, Li S, Sheng X, et al. Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: a study of 522 consecutive cases. BMC Cancer. 2011;11(1):85. doi:10.1186/1471-2407-11-85
- Gloster HM Jr, Neal K. Skin cancer in skin of color. J Am Acad Dermatol. 2006;55(5):741-760. doi:10.1016/j.jaad.2005.08.063
- Wu Y, Wang Y, Wang L, et al. Burden of melanoma in China, 1990-2017: Findings from the 2017 global burden of disease study. Int J Cancer. 2020;147(3):692-701. doi:10.1002/ijc.32764
- Zheng R, Zhang S, Zeng H, et al. Cancer incidence and mortality in China, 2016. J Natl Cancer Cent. 2022;2(1):1-9. doi:10.1016/j.jncc.2022.02.002
- Xu J, Wang X, Liu W, et al. Analysis and comparison of the trends in burden of malignant cutaneous melanoma in East Asian countries and regions and worldwide from 1991 to 2021. Front Public Health. 2025;13:1487177. doi:10.3389/fpubh.2025.1487177
- Joosse A, Collette S, Suciu S, et al. Sex is an independent prognostic indicator for survival and relapse/progression-free survival in metastasized stage III to IV melanoma: a pooled analysis of five European organisation for research and treatment of cancer randomized controlled trials. J Clin Oncol. 2013;31(18):2337-2346. doi:10.1200/JCO.2012.44.5031
- Yu L, Yan F, Qi J, et al. Burden of melanoma in China and its provinces from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021. Front Public Health. 2024;12:1486617. doi:10.3389/fpubh.2024.1486617
- Zhao C, Ma K, Wu Z, et al. The Burden of Malignant Skin Melanoma in China: From 1990 to 2021 with Estimation to 2036. medRxiv. Published online August 17, 2025. doi:10.1101/2025.08.11.25333476
- GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204-1222. doi:10.1016/S0140-6736(20)30925-9
- Soerjomataram I, Lortet-Tieulent J, Ferlay J, et al. Estimating and validating disability-adjusted life years at the global level: a methodological framework for cancer. BMC Med Res Methodol. 2012;12(1):125. doi:10.1186/1471-2288-12-125
- Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335-351. doi:10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z
- Volinsky CT, Raftery AE. Bayesian information criterion for censored survival models. Biometrics. 2000;56(1):256-262. doi:10.1111/j.0006-341X.2000.00256.x
- Yang Y, Schulhofer-Wohl S, Fu WJ, Land KC. The intrinsic estimator for age-period-cohort analysis: what it is and how to use it. Am J Sociol. 2008;113(6):1697-1736. doi:10.1086/587154
- Earnest A, Evans SM, Sampurno F, Millar J. Forecasting annual incidence and mortality rate for prostate cancer in Australia until 2022 using autoregressive integrated moving average (ARIMA) models. BMJ Open. 2019;9(8):e031331. doi:10.1136/bmjopen-2019-031331
- Wolchok JD, Chiarion-Sileni V, Gonzalez R, et al. Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma. J Clin Oncol. 2022;40(2):127-137. doi:10.1200/JCO.21.02229
- Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med. 2019;381(16):1535-1546. doi:10.1056/NEJMoa1910836
- Ke X, Lin W, Li D, et al. Spending and hospital stay for melanoma in Hunan, China. Front Public Health. 2022;10:917119. doi:10.3389/fpubh.2022.917119
- Enninga EAL, Moser JC, Weaver AL, et al. Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992-2011. Cancer Med. 2017;6(10):2203-2212. doi:10.1002/cam4.1152
- Bradford PT, Goldstein AM, McMaster ML, Tucker MA. Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. Arch Dermatol. 2009;145(4):427-434. doi:10.1001/archdermatol.2008.609
- Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-2147. doi:10.1056/NEJMoa050092
- Holman DM, Freeman MB, Shoemaker ML. Trends in melanoma incidence among non-Hispanic whites in the United States, 2005 to 2014. JAMA Dermatol. 2018;154(3):361-362. doi:10.1001/jamadermatol.2017.5541
- Richard MA, Grob JJ, Avril MF, et al. Delays in diagnosis and melanoma prognosis (II): the role of doctors. Int J Cancer. 2000;89(3):280-285. doi:10.1002/1097-0215(20000520)89:3<280::AID-IJC11>3.0.CO;2-2
