AccScience Publishing / GTM / Online First / DOI: 10.36922/GTM026200020
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REVIEW ARTICLE

Artificial intelligence for surgically resectable lung cancer: Toward a multimodal and clinically actionable framework

Zhuowei Li1,2,3,4† Xiaoqiu Yuan1,2,3,4† Yukun Chen1,2,3,4 Ruoyi Jin1,2,3,4 Yunchu Wei1,2,3,4 Xu Liu1,2,3,4 Lin Weng1,2,3,4 Huiting Su1,2,3,4 Ke-Zhong Chen1,2,3,4*
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1 Department of Thoracic Surgery, Thoracic Oncology Institute, Peking University People’s Hospital, Beijing, China
2 Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer, Chinese Academy of Medical Sciences, Beijing, China
3 Institute of Advanced Clinical Medicine, Peking University, Beijing, China
4 Frontiers Science Center for Cancer Integrative Omics, Peking University People’s Hospital, Beijing, China
†These authors contributed equally to this work.
Global Translational Medicine, 026200020 https://doi.org/10.36922/GTM026200020
Received: 17 May 2026 | Revised: 30 June 2026 | Accepted: 14 July 2026 | Published online: 29 July 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Lung cancer remains the leading cause of cancer incidence and mortality worldwide, and surgically resectable disease represents a critical window for cure. However, the current care continuum for resectable lung cancer remains limited by heterogeneous risk profiles, empirical decisions, fragmented integration of multi-dimensional information, and insufficient prediction of clinical outcomes. Under these circumstances, artificial intelligence (AI) has emerged as a promising approach for extracting clinically relevant information from complex data. Nevertheless, a synthesis of AI evidence across the full pathway of resectable lung cancer remains lacking, leaving clinicians uncertain about its clinical implementation. To address this gap, we narratively synthesize representative evidence regarding the evolution, technical platforms, and clinical applications of AI in resectable lung cancer, integrating how AI could support preoperative screening and diagnosis, intraoperative decision-making and procedures, as well as postoperative treatment and surveillance. We further discuss the major barriers to clinical translation, including limited external and prospective validation, patient safety, and accountability, followed by future directions. At present, many AI applications remain at an early exploratory stage, and further prospective evaluation is required to establish their clinical utility.

Graphical abstract
Keywords
Resectable lung cancer
Artificial intelligence
Precision surgery
Perioperative management
Multimodal data integration
Diagnosis and treatment
Funding
This work was supported by National Natural Science Foundation of China (82525052, 82450111, 82373416, 82388102); Chinese Academy of Medical Sciences (2021RU002); Beijing Natural Science Foundation (Z240013, L234002); Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0501900 & 2023ZD0501902); Beijing Research Ward Excellence Program (BRWEP2024W034080200 & BRWEP2024W034080204); Science, Technology & Innovation Project of Xiongan New Area (2023XAGG0071); CAMS Medical and Health Science and Technology Innovation Project (2021-I2M-5-002); and Peking University People’s Hospital Research and Development Funds (RZG2024-02). The funders had no role in the paper design, data collection, data analysis, interpretation, or writing of the paper.
Conflict of interest
The authors declare they have no competing interests.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing