AccScience Publishing / GTM / Online First / DOI: 10.36922/GTM025290055
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The effect of Moringa leaves on reducing blood glucose levels in diabetes mellitus patients: An experimental study

Agussalim Agussalim1*
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1 Department of Medical Surgical Nursing, Parepare School of Nursing, Makassar Health Polytechnic, Ministry of Health of the Republic of Indonesia, South Sulawesi, Indonesia
Global Translational Medicine, 025290055 https://doi.org/10.36922/GTM025290055
Received: 17 July 2025 | Revised: 13 August 2025 | Accepted: 1 September 2025 | Published online: 10 October 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by elevated blood glucose levels. Moringa oleifera leaves contain bioactive compounds that may contribute to glycemic regulation. This study aims to evaluate the effect of Moringa leaf extract on fasting blood glucose levels in patients with T2DM. A randomized controlled trial was conducted among 240 participants diagnosed with T2DM. The intervention group (n = 120) received 500 mg Moringa capsules twice daily for 30 days, while the control group (n = 120) received standard care without herbal supplementation. Fasting blood glucose was measured at baseline and after 30 days of intervention. The results demonstrated a significant reduction in fasting blood glucose in the intervention group, from 187.3 mg/dL to 132.6 mg/dL (p<0.001). In contrast, the control group showed a slight, non-significant decrease from 184.9 mg/dL to 179.2 mg/dL (p=0.072). Between-group analysis confirmed a significant difference in outcomes (p<0.001). These findings indicate that M. oleifera supplementation may serve as a beneficial adjunct therapy in improving glycemic control among patients with T2DM.

Keywords
Moringa leaves
Moringa oleifera
Diabetes mellitus
Blood glucose levels
Randomized controlled trial
Funding
None.
Conflict of interest
The author declares no conflict of interest.
References
  1. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: IDF; 2021.

 

  1. American Diabetes Association. Standards of medical care in diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S1-S291.

 

  1. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137-188. doi: 10.1152/physrev.00045.2011

 

  1. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. ScientificWorldJournal. 2013;2013:162750. doi: 10.1155/2013/162750

 

  1. Ong KW, Hsu A, Tan BK. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by AMPK activation. Biochem Pharmacol. 2013;85(9):1341-1351. doi: 10.1016/j.bcp.2013.02.008

 

  1. Ceriello A. Oxidative stress and glycemic regulation. Metabolism. 2000;49(2 Suppl 1):27-29. doi: 10.1016/s0026-0495(00)80082-7

 

  1. William R, Indah R, Pratiwi R. The effectiveness of Moringa oleifera leaf extract in lowering blood glucose levels in patients with type 2 diabetes mellitus. J Ethnopharmacol. 2020;249:112386.

 

  1. Hidayat S, Susanti H, Ningsih D. The effect of Moringa oleifera tea on fasting blood glucose levels in type 2 diabetes mellitus patients in East Java. J Kesehatan Masyarakat. 2021;17(2):89-95.

 

  1. Creswell JW, Creswell JD. Research Design: Qualitative, Quantitative, and Mixed Methods Approaches. 5th ed. Thousand Oaks: SAGE Publications; 2018.

 

  1. Kasolo JN, Bimenya GS, Ojok L, Ochieng J, Ogwal- Okeng JW. Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities. J Med Plants Res. 2010;4(9):753-757.

 

  1. Lim H, Son I, Song M. Clinical trial of a plant-based dietary supplement for glucose control in type 2 diabetes mellitus: A randomized, controlled, double-blind study. Complement Ther Med. 2019;45:1-7.

 

  1. Goyal BR, Agrawal BB, Goyal RK, Mehta AA. Phyto-pharmacology of Moringa oleifera Lam.: An overview. Nat Prod Radiance. 2007;6(4):347-353.

 

  1. Gupta R, Mathur M, Bajaj VK, et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes. 2012;4(2):164-171. doi: 10.1111/j.1753-0407.2011.00173.x

 

  1. Mbikay M. Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Front Pharmacol. 2012;3:24. doi: 10.3389/fphar.2012.00024

 

  1. Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J, Bertoli S. Moringa oleifera seeds and oil: Characteristics and uses for human health. Int J Mol Sci. 2016;17(12):2141. doi: 10.3390/ijms17122141

 

  1. Patel S, Dadhaniya P, Hingorani L, Soni MG. Safety assessment of Moringa oleifera seed extract: Data from a double-blind, randomized, placebo-controlled human study. Food Chem Toxicol. 2011;49(6):1270-1275.

 

  1. Bais S, Singh GS, Sharma R. Anti-diabetic effect of Moringa oleifera Lam. leaves in a diabetic rat model. Indian J Exp Biol. 2014;52(9):862-866.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing