AccScience Publishing / GPD / Volume 2 / Issue 4 / DOI: 10.36922/gpd.2141
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REVIEW

The roles and mechanisms of ETS1 in autoimmune diseases and cancers: A comprehensive review

Kai-Cheng Gao1,2† ,  Yu Zhao1,2† ,  Jie Jia1,2† ,  Dan Liang1,2 ,  Lin Xu1 ,  Yi-Qun Kuang1,2*
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1 Research Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
2 Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Kunming Medical University, Kunming, Yunnan, China
GPD 2023, 2(4), 2141 https://doi.org/10.36922/gpd.2141
Submitted: 30 October 2023 | Accepted: 14 December 2023 | Published: 26 December 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

E26 transformation-specific-1 (ETS1) is a founding member of the ETS transcription factor family. This transcription factor is highly conserved in amino acid sequences and highly expressed in many immune tissues, such as the thymus, spleen, and lymph gland. ETS1 plays multiple regulatory roles in immune-related diseases and acts as a transcriptional activator or inhibitor of many genes to regulate immune cell differentiation, development, apoptosis, and tumor occurrence. The expression level of ETS1 is correlated with disease severity. However, the molecular mechanisms behind disease and tumor progression mediated by ETS1 have not been fully elucidated. In addition, the therapeutic potential of ETS1 in clinical treatment remains to be further explored. Here, we review and summarize the molecular structure and functions of ETS1 and then focus on the roles of ETS1 in the occurrence of autoimmune diseases and cancers. This review provides a reference corroborating ETS1 as a potential therapeutic target for immune-related diseases and cancers.

Keywords
ETS1
Autoimmune diseases
Cancer
Immunity
Funding
National Natural Science Foundation of China
Joint Special Fund of the Department of Science and Technology, Yunnan Province – Kunming Medical University
Yunnan Fundamental Research Projects
Fund of Beijing Key Laboratory for HIV/AIDS Research
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Conflict of interest
The authors have no personal, financial, or institutional interest with regard to any of the drugs, materials, or devices described in this article.
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