AccScience Publishing / GPD / Volume 1 / Issue 2 / DOI: 10.36922/gpd.v1i2.99
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REVIEW

Exosomes: A bridge of periodontitis and systemic diseases

Jing Xu1,2† Xin Chang1,2† Huixin Zhang1,2 Mengying Si1,2 Huiying Su1,2 Lilan Cao1,2 Yingying Li3 Yuankun Zhai1,2,4*
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1 Department of Oral Biology, School of Stomatology, Henan University, Kaifeng, Henan, 475000, China
2 Kaifeng Key Laboratory of Periodontal Tissue Engineering, Kaifeng, Henan, 475000, China
3 Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Zhengzhou, Henan, 450000, China
4 Henan International Joint Laboratory for Nuclear Protein Regulation, Kaifeng, Henan, 475000, China
Submitted: 17 May 2022 | Accepted: 12 July 2022 | Published: 4 August 2022
© 2022 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Periodontitis, a common oral disease, is featured with complex etiology, progressive and prognosis varies according to the severity of periodontitis. Exosomes belong a kind of cystic vesicles with biological activity, which widely exist in human body fluids. Exosomes play an irreparable role in signal transmission and material exchange between cells, maintaining cell functions, and regulating body immunity and homeostasis. Exosomes are closely related to periodontitis, and recent study of exosomes has provided new directions and ideas for the diagnosis and treatment of periodontitis. Similarly, as extracellular vesicles, exosomes play a bridging role between periodontitis and some systemic diseases. In this process, exosomes participate in and regulate the process of systemic diseases by carrying nucleic acids, proteins, lipids, etc., and exhibit different bioactive effects according to the different substances carried in exosomes. In this paper, we summarize the latest research progress of exosomes, especially in the periodontitis and some systemic diseases, and review the potential value of exosomes in periodontitis diagnosis and treatments.

Keywords
Periodontitis
Exosomes
Periodontal regeneration
Osteoporosis
Kidney disease
Funding
Foundation of Science & Technology Department of Henan Province, China
Natural Science Foundation of Education Department of Henan Province, China
Foundation of National Health Commission of Henan Province, China
Foundation of Science & Technology Department of Luoyang City, Henan Province, China
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