AccScience Publishing / ARNM / Online First / DOI: 10.36922/ARNM025290035
MINI-REVIEW

Mini neutron tubes for boron neutron capture therapy and neutron imaging applications

Ka-Ngo Leung1*
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1 Department of Nuclear Engineering, University of California, Berkeley, California, United States of America
Received: 18 July 2025 | Revised: 10 September 2025 | Accepted: 17 September 2025 | Published online: 30 September 2025
(This article belongs to the Special Issue Boron Neutron Capture Therapy: A Renaissance)
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Recent advancements in negative deuterium and negative hydrogen ion source technology, as well as the commercial availability of high-frequency alternating-current high-voltage power supplies, have enabled the development of mini neutron generators using low-energy nuclear reactions. By operating these neutron tubes near the threshold energy of the p-7Li reaction, a useful flux of epithermal energy neutrons can be obtained. The new epithermal neutron sources can be configured for the treatment of deep-seeded tumors through boron neutron capture therapy (BNCT), for performing BNCT-brachytherapy or for the determination of 10B distribution in the tumor using the neutron transmission imaging technique. The new epithermal neutron tube is very compact and requires very low power for operation. It can easily combine BNCT with intraoperative radiotherapy or fast neutron therapy to enhance cancer treatment.

Keywords
Neutron tube
Epithermal neutrons
Boron neutron capture therapy
Intraoperative radiotherapy
Brachytherapy
Fast neutron therapy
Neutron transmission imaging
Funding
None.
Conflict of interest
The author declares no conflict of interest.
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Advances in Radiotherapy & Nuclear Medicine, Electronic ISSN: 2972-4392 Print ISSN: 3060-8554, Published by AccScience Publishing