Mini neutron tubes for boron neutron capture therapy and neutron imaging applications

Recent advancements in negative deuterium and negative hydrogen ion source technology, as well as the commercial availability of high-frequency alternating-current high-voltage power supplies, have enabled the development of mini neutron generators using low-energy nuclear reactions. By operating these neutron tubes near the threshold energy of the p-7Li reaction, a useful flux of epithermal energy neutrons can be obtained. The new epithermal neutron sources can be configured for the treatment of deep-seeded tumors through boron neutron capture therapy (BNCT), for performing BNCT-brachytherapy or for the determination of 10B distribution in the tumor using the neutron transmission imaging technique. The new epithermal neutron tube is very compact and requires very low power for operation. It can easily combine BNCT with intraoperative radiotherapy or fast neutron therapy to enhance cancer treatment.
- Leung KN. Production of H- ions by thermal desorption process. AIP Adv. 2023;13(7):075123. doi: 10.1063/5.0162487
- Leung KN. New mini neutron tubes with multiple applications. J Nucl Eng. 2024;5:197-208. doi: 10.3390/jne5030014
- Lee CL, Zhou XL. Thick target yields for the 7Li(p,n)7be reaction near threshold. Nucl Instrum Meth Phys Res B. 1999;152:1-11.
- Tanaka K, Kobayashi T, Sakurai Y, Nakagawa Y, Ishikawa M, Hoshi M. Irradiation characteristics of BNCT using near-threshold 7Li(p,n)7be direct neutrons: Application to intra-operative BNCT for malignant brain tumours. Phys Med Biol. 2002;47:3011-3032. doi: 10.1088/0031-9155/47/16/315
- Leung KN, Leung JK, Melville G. Feasibility study on medical isotope production using a compact neutron generator. Appl Radiat Isot. 2018;137C:23. doi: 10.1016/j.apradiso.2018.02.026
- Sauerwein WAG, Wittig A, Moss RL, Nakagawa Y, Ono K, editors. Neutron Capture Therapy. 2nd ed. Switzerland AG: Springer Nature; 2025. doi: 10.1007/978-3-031-82591-0
- Hasemi H, Kamiyama T, Kiyanagi Y. Studies on a pulsed thermal/epithermal neutron source with a compact accelerator for neutron imaging. Phys Proced. 2013;43:86-91. doi: 10.1016/j.phpro.2013.03.011
- Oba Y, Motokawa R, Kaneko K, et al. Neutron resonance absorption imaging of simulated high-level radioactive waste in borosilicate glass. Sci Rep. 2023;13:10071. doi: 10.1038/s41598-023-37157-2
- Zimmer M, Scheuren S, Kleinschmidt A, et al. Demonstration of non-destructive and isotope-sensitive material analysis using a short-pulsed laser-driven epi-thermal neutron source. Nat Commun. 2022;13:1173. doi: 10.1038/s41467-022-28756-0
- Durisi E, Zanini A, Manfredotti C, et al. Design of an epithermal column for BNCT based on D-D fusion neutron facility. Nucl Instrum Methods Phys Res A. 2007;574:363-369.
- Kononov VN, Bokhovko MV, Kononov OE, Soloviev NA, Chu WT, Nigg D, Accelerator-based fast neutron sources for neutron therapy. Nucl Instrum Methods Phys Res A. 2006;564:525. doi: 10.1016/j.nima.2006.03.043
- Brandao SF, Campos TPR. Intracavitary moderator balloon combined with (252)Cf brachytherapy and boron neutron capture therapy, improving dosimetry in brain tumour and infiltrations. Br J Radiol. 2015;88(1051):20140829. doi: 10.1259/bjr.20140829
- Leung KN, Leung JK. Cancer radiotherapy with mini neutron/gamma-ray generators. Adv Radiother Nucl Med. 2024;2(3):3920. doi: 10.36922/arnm.3920
- Leung KN. New compact neutron generator system for multiple applications. Nucl Technol. 2020;206:1607-1614. doi: 10.1080/00295450.2020.1719800
- Kageji T, Nakagawa Y, Kumada H. Clinical results of sodium borocaptate (BSH)-based intraoperative boron neutron capture therapy (IO-BNCT). In: Sauerwein WAG, Wittig A, Moss R, Nakagawa Y, editors. Neutron Capture Therapy. Berlin: Springer-Heidelberg; 2012.
- Brookhaven National Laboratory (BNL). Available from: http://www.nndc.bnl.gov