Functional reconstruction and tissue repair remain critical challenges in biomedical engineering and clinical translation. The convergence of biomaterials science, bioprinting technologies, stem cell biology, and regenerative medicine has enabled a paradigm shift from simple structural fabrication toward the creation of bioactive, adaptive, and intelligent constructs that actively participate in tissue regeneration. In particular, biodegradable and functionalized biomaterials, integrated with advanced bioprinting strategies and stem cell–driven tissue and organoid engineering, provide unprecedented opportunities for personalized tissue and organ repair, biomimetic microarchitectural design, and improved therapeutic outcomes.

This Special Issue aims to highlight recent advances and emerging trends in smart biomaterial additive manufacturing for functional reconstruction and tissue repair, spanning biomaterials design, composite material systems, structure–property regulation, and translational pathways. We invite high-quality original research articles, reviews, and perspectives that bridge fundamental material innovation, manufacturing technologies, and clinical applications.

Topics of interest include, but are not limited to:

• Design and functionalization of smartbiomaterials with tunable biological and physicochemical properties
• Bioprinting of personalized tissue-repair scaffolds and implantable or interventional medical devices
• Additive manufacturing of composite biomaterials and regulation of their mechanical, biological, and multifunctional performance
• Smart bioprinted constructs with drug delivery, stimuli-responsive, or shape-memory capabilities
• In vivo evaluation, regulatory considerations, and clinical translation pathways of intelligent bioprinted structures
• Sustainable and bioinspired manufacturing strategies for intelligent biomaterials, including the use of naturalresources and biomimetic design principles
• 4D bioprinting with programmable shape transformation or functional evolution、

Keywords: Bioprinting; Smart biomaterials; Biodegradable bioinks; Additive manufacturing; Tissue repair; Functional reconstruction; Clinical translation