AccScience Publishing / IJB / Volume 9 / Issue 6 / DOI: 10.36922/ijb.0114
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Exosome-based bioinks for 3D bioprinting applications in tissue engineering and regenerative medicine

Qian Wang1 Yang Liu1 Shuqing Zhang1 Fan He2 Tong Shi3 Jizong Li3* Zhimin Wang4* Jia Jia1,2*
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1 School of Life Sciences, Shanghai University, Shanghai, China
2 Sino-Swiss Institute of Advanced Technology, School of Micro-electronics, Shanghai University, Shanghai, China
3 Shanghai Center of Biomedicine Development, Shanghai, China
4 Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, China
Submitted: 4 April 2023 | Accepted: 12 May 2023 | Published: 7 July 2023
(This article belongs to the Special Issue 3D printing for tissue engineering and regenerative medicine)
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Bioprinting is an emerging technology for tissue engineering and regenerative medicine. Despite its fast, accurate manufacture for tissues and organs in vitro, bioprinting has been seriously limited for biofabrication because of the restricted approaches to reproducing the extracellular matrix (ECM) with sufficient bioactivities for bioprinted cells. Exosomes are natural biological particles with proteins, lipids, or genetic materials. They have distinct properties and unique biological functions to manipulate cellular behaviors and cell fates, showing great potential to support cells for bioprinting. Here, we reviewed the recent progresses of exosome-advanced bioprinting for tissue engineering and regenerative medicine. Firstly, we offer an overview of the basics of exosomes and the current representative applications of exosomes in bone tissue engineering, immunological regulations, angiogenesis, and neural regenerations. Then, a brief introduction about the bioinks and the currently developed bioprinting methods is provided. We further give an in-depth review of the biomedical applications of bioprinting with exosomes, majorly in bone engineering, vascular engineering, therapy of neuron injury, and skin regeneration. We also conclude with an outlook on the challenges of the unmet needs of bioprinting cells with correspondent ECM environments through bioprinting with exosomes.

Regenerative medicine
Tissue engineering
Zhimin Wang reports financial support was provided by National Natural Science Foundation of China (No. 51833006) and Innovation Promotion Program of NHC and Shanghai Key Labs, SIBPT (No. CX2023-03). Jia Jia reports financial support was provided by Shanghai University (No. N-58-D305-22-204). Jizong Li reports financial support was provided by Science and Technology Commission of Shanghai Municipality (No. 17DZ2260600 & No. 22692116403).
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Conflict of interest
The authors declare no conflict of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing