Houdek MT, Shin AY, 2015, Management and complications of traumatic peripheral nerve injuries. Hand Clin, 31(2): 151–63. https://doi.org/10.1016/j.hcl.2015.01.007

Taylor CA, Braza D, Rice JB, et al., 2008, The incidence of peripheral nerve injury in extremity trauma. Am J Phys Med Rehabil, 87(5): 381–385. https://doi.org/10.1097/PHM.0b013e31815e6370

Grijalvo S, Díaz DD, 2021, Graphene-based hybrid materials as promising scaffolds for peripheral nerve regeneration. Neurochem Int, 147: 105005. https://doi.org/10.1016/j.neuint.2021.105005

Yi S, Xu L, Gu X, 2019, Scaffolds for peripheral nerve repair and reconstruction. Exp Neurol, 319: 112761. https://doi.org/10.1016/j.expneurol.2018.05.016

Yin G, Peng Y, Lin Y, et al., 2021, Long non-coding RNA MSTRG.24008.1 regulates the regeneration of the sciatic nerve via the miR-331-3p-NLRP3/MAL axis. Front Cell Dev Biol, 9: 641603. https://doi.org/10.3389/fcell.2021.641603

Bombeiro AL, Santini JC, Thomé R, et al., 2016, Enhanced immune response in immunodeficient mice improves peripheral nerve regeneration following axotomy. Front Cell Neurosci, 10: 151. https://doi.org/10.3389/fncel.2016.00151

Jiang H, Wang X, Li X, et al., 2022, A multifunctional ATP-generating system by reduced graphene oxide-based scaffold repairs neuronal injury by improving mitochondrial function and restoring bioelectricity conduction. Mater Today Bio, 13: 100211. https://doi.org/10.1016/j.mtbio.2022.100211

Mendes PM, 2008, Stimuli-responsive surfaces for bio-applications. Chem Soc Rev, 37(11): 2512–2529. https://doi.org/10.1039/b714635n

Zhu L, Jia S, Liu T, et al., 2020, Aligned PCL fiber conduits immobilized with nerve growth factor gradients enhance and direct sciatic nerve regeneration. 30(39): 2002610. https://doi.org/10.1002/adfm.202002610

Houshyar S, Bhattacharyya A, Shanks R, 2019, Peripheral nerve conduit: Materials and Structures. ACS Chem Neurosci, 10(8): 3349–3365. https://doi.org/10.1021/acschemneuro.9b00203

Zhang J, Zhang X, Wang C, et al., 2021, Conductive composite fiber with optimized alignment guides neural regeneration under electrical stimulation. 10(3): 2000604. https://doi.org/10.1002/adhm.202000604

Zhang X, Qu W, Li D, et al., 2020, Functional polymer-based nerve guide conduits to promote peripheral nerve regeneration. Adv Mater Interfaces, 7(14): 2000225. https://doi.org/10.1002/admi.202000225

Gong B, Zhang X, Zahrani AA, et al., 2022, Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration. Exploration, 2(3): 20210035. https://doi.org/10.1002/EXP.20210035

Li G, Li S, Zhang L, et al., 2019, Construction of biofunctionalized anisotropic hydrogel micropatterns and their effect on schwann cell behavior in peripheral nerve regeneration. ACS Appl Mater Interfaces, 11(41): 37397–37410. https://doi.org/10.1021/acsami.9b08510

Grasman JM, Ferreira JA, Kaplan DL, 2018, Tissue models for neurogenesis and repair in 3D. Adv Funct Mater, 28(48): 1803822. https://doi.org/10.1002/adfm.201803822

Liu C, Chan C, 2016, An approach to enhance alignment and myelination of dorsal root ganglion neurons. J Vis Exp, (114): 54085. https://doi.org/10.3791/54085

Jia Y, Yang W, Zhang K, et al., 2019, Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes. Acta Biomater, 83: 291–301. https://doi.org/10.1016/j.actbio.2018.10.040

Hoffman-Kim D, Mitchel JA, Bellamkonda RV, 2010, Topography, cell response, and nerve regeneration. Annu Rev Biomed Eng, 12: 203–231. https://doi.org/10.1146/annurev-bioeng-070909-105351

Huang C, Ouyang Y, Niu H, et al., 2015, Nerve guidance conduits from aligned nanofibers: Improvement of nerve regeneration through longitudinal nanogrooves on a fiber surface. ACS Appl Mater Interfaces, 7(13): 7189–7196. https://doi.org/10.1021/am509227t

Zhang Y, Xu Y, Kong H, et al., 2023, Microneedle system for tissue engineering and regenerative medicine. Exploration, 3(1): 20210170. https://doi.org/10.1002/EXP.20210170

Liu K, Yan L, Li R, et al., 3D printed personalized nerve guide conduits for precision repair of peripheral nerve defects. Adv Sci, 9(12): 2103875. https://doi.org/10.1002/advs.202103875

Ding J, Zhang J, Li J, et al., 2019, Electrospun polymer biomaterials. Prog Polym Sci, 90: 1–34. https://doi.org/10.1016/j.progpolymsci.2019.01.002

Wan X, Zhao Y, Li Z, et al., 2022, Emerging polymeric electrospun fibers: From structural diversity to application in flexible bioelectronics and tissue engineering. Exploration, 2(1): 20210029. https://doi.org/10.1002/EXP.20210029

Zhao C, Wang X, Gao L, et al., 2018, The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells. Acta Biomater, 73: 509–521. https://doi.org/10.1016/j.actbio.2018.04.030

Mansouri N, Bagheri S, 2016, The influence of topography on tissue engineering perspective. Mater Sci Eng C Mater Biol Appl, 61: 906–921. https://doi.org/10.1016/j.msec.2015.12.094

Klymov A, Rodrigues Neves CT, te Riet J, et al., 2015, Nanogrooved surface-patterns induce cellular organization and axonal outgrowth in neuron-like PC12-cells. Hear Res, 320: 11–17. https://doi.org/10.1016/j.heares.2014.12.009

Zhang D, Yao Y, Duan Y, et al., 2020, Surface-anchored graphene oxide nanosheets on cell-scale micropatterned poly(d,l-lactide-co-caprolactone) conduits promote peripheral nerve regeneration. ACS Appl Mater Interfaces, 12(7): 7915–7930. https://doi.org/10.1021/acsami.9b20321

Omidinia-Anarkoli A, Ephraim JW, Rimal R, et al., 2020, Hierarchical fibrous guiding cues at different scales influence linear neurite extension. Acta Biomater, 113: 350–359. https://doi.org/10.1016/j.actbio.2020.07.014

Li G, Zheng T, Wu L, et al., 2021, Bionic microenvironment-inspired synergistic effect of anisotropic micro-nanocomposite topology and biology cues on peripheral nerve regeneration. Sci Adv, 7(28): 5812. https://doi.org/10.1126/sciadv.abi5812

Li G, Zhao X, Zhang L, et al., 2014, Regulating Schwann cells growth by chitosan micropatterning for peripheral nerve regeneration in vitro. Macromol Biosci, 14(8): 1067–1075. https://doi.org/10.1002/mabi.201400098

Iadecola C, 2010, The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol, 120(3): 287–296. https://doi.org/10.1007/s00401-010-0718-6

Martínez G, Khatiwada S, Costa-Mattioli M, et al., 2018, ER proteostasis control of neuronal physiology and synaptic function. Trends Neurosci, 41(9): 610–624. https://doi.org/10.1016/j.tins.2018.05.009

Wang T, Zhong X, Wang S, et al., 2012, Molecular mechanisms of RADA16-1 peptide on fast stop bleeding in rat models. Int J Mol Sci, 13(11): 15279–15290. https://doi.org/10.3390/ijms131115279

Hu G, Xiao L, Tong P, et al., 2012, Antibacterial hemostatic dressings with nanoporous bioglass containing silver. Int J Nanomed, 7: 2613–2620. https://doi.org/10.2147/ijn.S31081

Dong H, Li Z, Bian S, et al., 2022, Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening. Bioact Mater, 18: 164–177. https://doi.org/10.1016/j.bioactmat.2022.03.020

Yu X, Zhu D, Luo B, et al., 2022, IFNγ enhances ferroptosis by increasing JAK STAT pathway activation to suppress SLCA711 expression in adrenocortical carcinoma. Oncol Rep, 47(5): 97. https://doi.org/10.3892/or.2022.8308

Nika MC, Ntaiou K, Elytis K, et al., 2020, Wide-scope target analysis of emerging contaminants in landfill leachates and risk assessment using Risk Quotient methodology. J Hazard Mater, 394: 122493. https://doi.org/10.1016/j.jhazmat.2020.122493

Xia W, Zhu J, Wang X, et al., 2020, Overexpression of Foxc1 regenerates crushed rat facial nerves by promoting Schwann cells migration via the Wnt/β-catenin signaling pathway. J Cell Phys, 235(12): 9609–9622. https://doi.org/10.1002/jcp.29772

Rao F, Wang Y, Zhang D, et al., 2020, Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats. Theranostics, 10(4): 1590–1603. https://doi.org/10.7150/thno.36272

Torres-Mejía E, Trümbach D, Kleeberger C, et al., 2020, Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis. Sci Rep, 10(1): 1984. https://doi.org/10.1038/s41598-019-56877-y

Riggio C, Calatayud MP, Hoskins C, et al., 2012, Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance. Int J Nanomed, 7: 3155–3166. https://doi.org/10.2147/ijn.S28460

Cai J, Peng X, Nelson KD, et al., 2005, Permeable guidance channels containing microfilament scaffolds enhance axon growth and maturation. J Biomed Mater Res A, 75(2): 374–386. https://doi.org/10.1002/jbm.a.30432

Puhl DL, Funnell JL, D’Amato AR, et al., 2020, Aligned fingolimod-releasing electrospun fibers increase dorsal root ganglia neurite extension and decrease schwann cell expression of promyelinating factors. Front Bioeng Biotechnol, 8: 937. https://doi.org/10.3389/fbioe.2020.00937

Morano M, Wrobel S, Fregnan F, et al., 2014, Nanotechnology versus stem cell engineering: In vitro comparison of neurite inductive potentials. Int J Nanomed, 9: 5289–5306. https://doi.org/10.2147/ijn.S71951

Li M, Tang Z, Lv S, et al., 2014, Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin. Biomaterials, 35(12): 3851–3864. https://doi.org/10.1016/j.biomaterials.2014.01.018

Cao F, Ju E, Zhang Y, et al., 2017, An efficient and benign antimicrobial depot based on silver-infused MoS(2). ACS Nano, 11(5): 4651–4659. https://doi.org/10.1021/acsnano.7b00343

Xu Y, Zhou J, Liu C, et al., 2021, Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials, 268: 120596. https://doi.org/10.1016/j.biomaterials.2020.120596

Alvarsson A, Jimenez-Gonzalez M, Li R, et al., 2020, A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes. Sci Adv, 6(41): 9124. https://doi.org/10.1126/sciadv.aaz9124

Asbury AK, King RH, Reilly MM, et al., 2011, Professor P. K. Thomas: clinician, investigator, editor and leader--a retrospective appreciation. Brain, 134(Pt 2): 618–626. https://doi.org/10.1093/brain/awq230

Afshari FT, Kwok JC, White L, et al., 2010, Schwann cell migration is integrin-dependent and inhibited by astrocyte-produced aggrecan. Glia, 58(7): 857–869. https://doi.org/10.1002/glia.20970

Benoy V, Van Helleputte L, Prior R, et al., 2018, HDAC6 is a therapeutic target in mutant GARS-induced Charcot- Marie-Tooth disease. Brain, 141(3): 673–687. https://doi.org/10.1093/brain/awx375

Hu H, Jonas P, 2014, A supercritical density of Na(+) channels ensures fast signaling in GABAergic interneuron axons. Nat Neurosci, 17(5): 686–693. https://doi.org/10.1038/nn.3678

Eichel MA, Gargareta VI, D’Este E, et al., 2020, CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves. Nat Commun, 11(1): 4514. https://doi.org/10.1038/s41467-020-18172-7

Wang L, Lu C, Yang S, et al., 2020, A fully biodegradable and self-electrified device for neuroregenerative medicine. Sci Adv, 6(50): 6686. https://doi.org/10.1126/sciadv.abc6686

Jin B, Yu Y, Chen X, et al., 2023, Microtubes with gradient decellularized porcine sciatic nerve matrix from microfluidics for sciatic nerve regeneration. Bioact Mater, 21: 511–519. https://doi.org/10.1016/j.bioactmat.2022.08.027

Mayoral I, Bevilacqua E, Gómez G, et al., 2022, Tissue engineered in-vitro vascular patch fabrication using hybrid 3D printing and electrospinning. Mater Today Bio, 14: 100252. https://doi.org/10.1016/j.mtbio.2022.100252

Fan D, Yuan X, Wu W, et al., 2022, Self-shrinking soft demoulding for complex high-aspect-ratio microchannels. Nat Commun, 13(1): 5083. https://doi.org/10.1038/s41467-022-32859-z

Liu Y, Dabrowska C, Mavousian A, et al., 2021, Bio-assembling macro-scale, lumenized airway tubes of defined shape via multi-organoid patterning and fusion. Adv Sci, 8(9): 2003332. https://doi.org/10.1002/advs.202003332

Farhat W, Chatelain F, Marret A, et al., 2021, Trends in 3D bioprinting for esophageal tissue repair and reconstruction. Biomaterials, 267: 120465. https://doi.org/10.1016/j.biomaterials.2020.120465

Chen S, Li R, Li X, et al., 2018, Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine. Adv Drug Deliv Rev, 132: 188–213. https://doi.org/10.1016/j.addr.2018.05.001

Yao Z, Yuan W, Xu J, et al., 2022, Magnesium-encapsulated injectable hydrogel and 3D-engineered polycaprolactone conduit facilitate peripheral nerve regeneration. Adv Sci, 9(21): e2202102. https://doi.org/10.1002/advs.202202102

Zhu M, Li W, Dong X, et al., 2019, In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration. Nat Commun, 10(1): 4620. https://doi.org/10.1038/s41467-019-12545-3

Qian Y, Zhao X, Han Q, et al., 2018, An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration. Nat Commun, 9(1): 323. https://doi.org/10.1038/s41467-017-02598-7

Cui X, Jing J, Wu R, et al., 2021, Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue. Nat Commun, 12(1): 5362. https://doi.org/10.1038/s41467-021-25766-2

Han Q, Ordaz JD, Liu NK, et al., 2019, Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice. Nat Commun, 10(1): 5815. https://doi.org/10.1038/s41467-019-13854-3

Takano T, Wu M, Nakamuta S, et al., 2017, Discovery of long-range inhibitory signaling to ensure single axon formation. Nat Commun, 8(1): 33. https://doi.org/10.1038/s41467-017-00044-2

Lai BQ, Wang JM, Ling EA, et al., 2014, Graft of a tissue-engineered neural scaffold serves as a promising strategy to restore myelination after rat spinal cord transection. Stem Cells Dev, 23(8): 910–921. https://doi.org/10.1089/scd.2013.0426

Yoshimura T, Kawano Y, Arimura N, et al., 2005, GSK- 3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell, 120(1): 137–149:. https://doi.org/10.1016/j.cell.2004.11.012

Liu D, Shu G, Jin F, et al., 2020, ROS-responsive chitosan- SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule. Sci Adv, 6(41): 7422. https://doi.org/10.1126/sciadv.abb7422

Chan LW, Kim CH, Wang X, et al., 2016, PolySTAT-modified chitosan gauzes for improved hemostasis in external hemorrhage. Acta Biomater, 31: 178–185. https://doi.org/10.1016/j.actbio.2015.11.017

Zakhem E, Raghavan S, Bitar KN, 2014, Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Biomaterials, 35(6): 1882–1889. https://doi.org/10.1016/j.biomaterials.2013.11.049

Li J, Shu Y, Hao T, et al., 2013, A chitosan-glutathione based injectable hydrogel for suppression of oxidative stress damage in cardiomyocytes. Biomaterials, 34(36): 9071–9081. https://doi.org/10.1016/j.biomaterials.2013.08.031

Lu Q, Zhang F, Cheng W, et al., 2021, Nerve guidance conduits with hierarchical anisotropic architecture for peripheral nerve regeneration. Adv Healthc Mater, 10(14): e2100427. https://doi.org/10.1002/adhm.202100427

Hsueh YY, Chang YJ, Huang TC, et al., 2014, Functional recoveries of sciatic nerve regeneration by combining chitosan-coated conduit and neurosphere cells induced from adipose-derived stem cells. Biomaterials, 35(7): 2234– 2244. https://doi.org/10.1016/j.biomaterials.2013.11.081

Mekhail M, Almazan G, Tabrizian M, 2015, Purine-crosslinked injectable chitosan sponges promote oligodendrocyte progenitor cells’ attachment and differentiation. Biomater Sci, 3(2): 279–287. https://doi.org/10.1039/c4bm00215f

Li X, Yang Z, Zhang A, 2009, The effect of neurotrophin-3/ chitosan carriers on the proliferation and differentiation of neural stem cells. Biomaterials, 30(28): 4978–4985. https://doi.org/10.1016/j.biomaterials.2009.05.047

Liu K, Yan L, Li R, et al., 2022, 3D printed personalized nerve guide conduits for precision repair of peripheral nerve defects. Adv Sci, 9(12): e2103875. https://doi.org/10.1002/advs.202103875

Chen S, John JV, McCarthy A, et al., 2020, Fast transformation of 2D nanofiber membranes into pre-molded 3D scaffolds with biomimetic and oriented porous structure for biomedical applications. Appl Phys Rev, 7(2): 021406. https://doi.org/10.1063/1.5144808

Joung D, Lavoie NS, Guo SZ, et al., 2020, 3D printed neural regeneration devices. Adv Funct Mater, 30(1): 10. https://doi.org/10.1002/adfm.201906237