The first 3D-bioprinted personalized active bone to repair bone defects: A case report

Yongqiang Hao^1,2,3†*, Bojun Cao^1,2,3†, Liang Deng^1,2,3, Jiaxin Li^1,2,3,4,, Zhaoyang Ran^1,2,3, Junxiang Wu^1,2,3, Boran Pang^1,2,3, Jia Tan^1,2,3, Dinghao Luo^1,2,3, Wen Wu^1,2,3

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¹ Clinical and Translational Research Center for 3D Printing Technology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

² Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

³ Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

⁴ Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

†These authors contributed equally to this work.

IJB 2023, 9(2), 654 https://doi.org/10.18063/ijb.v9i2.654

Received: 23 October 2022 | Accepted: 8 December 2022 | Published online: 22 December 2022

(This article belongs to the Special Issue Novel Methods, Processes, and Materials of Bioprinting)

© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

The repair and reconstruction of bone defects are still major problems to be solved in the field of orthopedics. Meanwhile, 3D-bioprinted active bone implants may provide a new and effective solution. In this case, we used bioink prepared from the patient’s autologous platelet-rich plasma (PRP) combined with polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) composite scaffold material to print personalized PCL/β-TCP/ PRP active scaffolds layer by layer through 3D bioprinting technology. The scaffold was then applied in the patient to repair and reconstruct bone defect after tibial tumor resection. Compared with traditional bone implant materials, 3D-bioprinted personalized active bone will have significant clinical application prospects due to its advantages of biological activity, osteoinductivity, and personalized design.

Keywords

Bone defect

3D bioprinting

Personalized active bone

Platelet-rich plasma

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