AccScience Publishing / IJB / Volume 9 / Issue 1 / DOI: 10.18063/ijb.v9i1.625
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RESEARCH ARTICLE

Effect of ionic crosslinking on morphology and thermostability of biomimetic supercritical fluids-decellularized dermal-based composite bioscaffolds for bioprinting applications 

Run-Miao Yang1,2† Jun Xu2,3,4† Ching-Cheng Huang5,6 *
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1 Department of Material Engineering, Jiangsu University of Technology, Chang Zhou, Jiangsu, China
2 PARSD Biomedical Material Research Center (Chang Zhou), Chang Zhou, Jiangsu, China
3 College of Food Science and Engineering, Hainan University; Engineering Research Center of Utilization of Tropical Polysaccharide Resources, Ministry of Education, Haikou 570 228, Hainan, China
4 State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, CAS 100 190, Beijing, China
5 Department of Biomedical Engineering, Ming-Chuan University, Taoyuan 320-33, Taiwan
6 PARSD Biomedical Material Research Center (Taiwan), Taichung, Taiwan
Submitted: 27 April 2022 | Accepted: 11 August 2022 | Published: 27 October 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

In the present study, supercritical fluid was employed to prepare a kind of supercritical fluids-decellularized dermal-based scaffold (SFDDS) from porcine dermal tissue. Further, new composite bioscaffolds containing SFDDS were designed for bioprinting applications. Then, the effect of crosslinking functionality on microstructures and thermal properties of the composite bioscaffolds containing decellularized extracellular matrix were studied. The results of thermal stability from thermogravimetric analysis and difference thermogravimetry demonstrated the structural stability of the composite bioscaffolds. A method was designed to prepare bioinspired decellularized dermal-based composite bioscaffolds, which were further characterized by infrared spectroscopy, scanning electron microscopy, and thermogravimetry analysis.

Keywords
Alginate
Composite membrane
Decellularization
Microstructure
Supercritical carbon dioxide
References

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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing