AccScience Publishing / IJB / Volume 5 / Issue 2 / DOI: 10.18063/ijb.v5i2.197
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RESEARCH ARTICLE

The mussel-inspired assisted apatite mineralized on PolyJet material for artificial bone scaffold

Yi-Wen Chen1,2† ,  Hsin-Yuan Fang1,3,4† ,  Ming-You Shie1,5 ,  Yu-Fang Shen6,7*
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1 Three-dimensional Printing Medical Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan
2 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
3 Department of Thoracic Surgery, China Medical University Hospital, Taichung, Taiwan
4 School of Medicine, China Medical University, Taichung, Taiwan
5 School of Dentistry, China Medical University, Taichung, Taiwan
6 Three-dimensional Printing Medical Research Institute, Asia University, Taichung, Taiwan
7 Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
IJB 2019, 5(2), 197 https://doi.org/10.18063/ijb.v5i2.197
Published: 11 July 2019
© 2019 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

With the development of three-dimensional (3D) printing, many commercial 3D printing materials have been applied in the fields of biomedicine and medical. MED610 is a clear, biocompatible PolyJet material that is medically certified for bodily contact. In this study, the polydopamine (PDA)/hydroxyapatite (HA) coating was added to the printed MED610 objects to evaluate its physical properties, cell proliferation, cell morphology, and alkaline phosphatase expression level. The results show that the PDA/HA coating helps printed objects to enhance the hardness, biocompatibility, and osteogenic differentiation potential. We expect that PDA/HA coatings contribute to the applicability of MED610 in biomedical and medical applications.

Keywords
Three-dimensional printing
Polydopamine
Hydroxyapatite
MED610
Osteogenic differentiation
PolyJet technology
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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