The climate change–noncommunicable disease nexus: Addressing the dual burden on global health
The convergence of climate change and noncommunicable diseases (NCDs) forms a critical global health syndemic, disproportionately impacting low- and middle-income countries (LMICs) and marginalized populations. NCDs—e.g., cardiovascular diseases, cancers, chronic respiratory conditions, and diabetes—cause over 70% of global deaths, with 78% of mortality and 85% of premature deaths in LMICs. Climate change exacerbates this burden through direct pathways, such as heatwaves, which trigger cardiovascular and renal events, and indirect pathways, including disrupted food systems that drive obesity and diabetes, and air pollution that worsens respiratory and cardiovascular health. Psychosocial stress from climate change-induced displacement and disasters further amplifies mental health disorders, interacting with NCD risk. Vulnerable groups, including migrants, indigenous communities, and the urban poor, face compounded risks due to fragile health systems and socio-economic inequities. Small Island Developing States and regions such as Sub-Saharan Africa exemplify these challenges, with rising NCD prevalence amid environmental stressors. Addressing this nexus demands integrated strategies: a strengthened health system, enhanced surveillance, equitable policies, and sustainable development.
Abubakar, I. R., Onyebueke, V. U., Lawanson, T., Barau, A. S., & Bununu, Y. A. (2025). Urban planning strategies for addressing climate change in Lagos megacity, Nigeria. Land Use Policy, 153, 107524. https://doi.org/10.1016/j.landusepol.2025.107524
Amrutbhai V. K., Pratapbhai S.A., & Dhamal J. (2025). Epidemiological Assessment of Lifestyle Risk Factors Contributing to Non-Communicable Diseases in Urban Slum Populations. Journal of Heart Valve Disease, 30(4), 70-77.
Breitner-Busch, S., Mucke, H., Schneider, A., & Hertig, E. (2023). Impact of climate change on non-communicable diseases due to increased ambient air pollution. Journal of Health Monitoring, 8(4),103-121. https://doi.org/10.25646/11655.2
De Siqueira-Filha, N.T., Li, J., Kibuchi, E., et al. (2021). Economics of Healthcare Access in Low-income and Middle-income Countries: A Protocol for a Scoping Review of the Economic Impacts of Seeking Healthcare on Slum-dwellers Compared With Other City Residents. BMJ Open, 11(7),e045441. https://doi.org/10.1136/bmjopen-2020-045441
Di Ciaula, A., Krawczyk, M., Filipiak, K. J., Geier, A., Bonfrate, L., & Portincasa, P. (2021). Noncommunicable diseases, climate change and iniquities: What COVID‐19 has taught us about syndemic. European Journal of Clinical Investigation, 51(12). https://doi.org/10.1111/eci.13682
Ebi, K. L., Vanos, J., Baldwin, J. W., Bell, J. E., Hondula, D. M., Errett, N. A., Hayes, K., Reid, C. E., Saha, S., Spector, J., & Berry, P. (2021). Extreme weather and climate change: Population health and health system implications. Annual Review of Public Health, 42(1), 293–315. https://doi.org/10.1146/annurev-publhealth-012420-105026
Fanzo, J., Rudie, C., Sigman, I., et al. (2021). Sustainable food systems and nutrition in the 21st century: a report from the 22nd annual Harvard Nutrition Obesity Symposium. The American Journal of Clinical Nutrition, 115(1), 18–33. https://doi.org/10.1093/ajcn/nqab315
Fritz, M. (2022). Temperature and non‐communicable diseases: Evidence from Indonesia’s primary health care system. Health Economics, 31(11), 2445–2464. https://doi.org/10.1002/hec.4590
Goldfarb, D. S., & Patel, A. A. (2024). Climate change and its implications for kidney health. Current Opinion in Urology, 34(5), 377-383. https://doi.org/10.1097/mou.0000000000001197
Grey, K., Gonzales, G. B., Abera, M., Lelijveld, N., Thompson, D., Berhane, M., Abdissa, A., Girma, T., & Kerac, M. (2021). Severe malnutrition or famine exposure in childhood and cardiometabolic non-communicable disease later in life: a systematic review. BMJ Global Health, 6(3), e003161. https://doi.org/10.1136/bmjgh-2020-003161
Guell, C., Saint Ville, A., Anderson, S. G., Murphy, M. M., Iese, V., Kiran, S., Hickey, G. M., & Unwin, N. (2024). Small Island Developing States: addressing the intersecting challenges of non-communicable diseases, food insecurity, and climate change. The Lancet Diabetes & Endocrinology, 12(6), 422–432. https://doi.org/10.1016/s2213-8587(24)00100-1
Gupta, I., & Singh, A. K. (2025). Addressing Urban Health Challenges in India: Shifting Focus to the Urban Poor. Centre for Social and Economic Progress. Available from: https://csep.org/wp-content/uploads/2025/03/Addressing-Urban-Health-Challenges-in-India-Shifting-Focus-to-the-Urban-Poor.pdf [Last accessed on 2026 Mar 20].
Gupta, D., Kumar, P., Okano, N., & Sharma, M. (2025). Climate-Induced Migration in India and Bangladesh: A Systematic Review of Drivers, Impacts, and Adaptation Mechanisms. Climate, 13(4), 81. https://doi.org/10.3390/cli13040081
Hunter, R. F., Garcia, L., Dagless, S., Haines, A., Penney, T., Clifford Astbury, C., Whiting, S., Wickramasinghe, K., Racioppi, F., Galea, G., & Kluge, H. H. P. (2024). The emerging syndemic of climate change and non-communicable diseases. The Lancet Planetary Health, 8(7), e430–e431. https://doi.org/10.1016/S2542-5196(24)00112-8
Intergovernmental Panel on Climate Change. (2022). Climate Change 2022: Impacts, Adaptation and Vulnerability. IPCC Sixth Assessment Report. Available from: https://www.ipcc.ch/report/ar6/wg2/ [Last accessed on 2026 Mar 20].
Kalra, A., Jose, A. P., Prabhakaran, P., Kumar, A., Agrawal, A., Roy, A., Bhargava, B., Tandon, N., & Prabhakaran, D. (2023). The burgeoning cardiovascular disease epidemic in Indians– perspectives on contextual factors and potential solutions. The Lancet Regional Health -Southeast Asia, 12, 100156. https://doi.org/10.1016/j.lansea.2023.100156
Kaur, M., Sharma, A., Vijin, P., Kaur, R., Kaur, R., Anupama, G., Singh, P., Bansal, V. K., Sharma, N., Sahni, M., Gupta, J., Lakshmi, P., & Kumar, R. (2024). Exploring the Complexities of Slum Vulnerability in Haryana, India: A Qualitative Research Journey Into Economic, Social, Physical, and Health Dimensions. International Journal of Qualitative Studies on Health and Well-Being, 20(1), 2432692. doi.org/10.1080/17482631.2024.2432692
Lumagbas, L. B., Coleman, H. L. S., Bunders, J., Pariente, A., Belonje, A., & de Cock Buning, T. (2018). Noncommunicable diseases in Indian slums: re-framing the Social Determinants of Health. Global Health Action, 11(1), 1438840. https://doi.org/10.1080/16549716.2018.1438840
Malhi, J. K., McEvoy, J. W., Blumenthal, R. S., & Jacobsen, A. P. (2024). Climate change and cardiovascular health: Recent updates and actions for healthcare. American Heart Journal plus: Cardiology Research and Practice, 45, 100443. https://doi.org/10.1016/j.ahjo.2024.100443
Mandal, B., & Kalandi, C.P. (2025). Association Between Ruralto-urban Migration and the Onset of Hypertension Among Middle-aged and Older Population: Evidence From India. BMC Public Health, 25(1). https://doi.org/10.1186/s12889-025-22267-5
Martins, F. P., Paschoalotto, M. A. C., Closs, J., Bukowski, M., & Veras, M. M. (2024). The Double Burden: Climate Change Challenges for Health Systems. Environmental Health Insights, 18. https://doi.org/10.1177/11786302241298789
McMichael, C., Barnett, J., & McMichael, A. J. (2012). An Ill Wind? Climate Change, Migration, and Health. Environmental Health Perspectives, 120(5), 646–654. https://doi.org/10.1289/ehp.1104375
Melaku, Y. A., Gill, T. K., Taylor, A. W., Appleton, S. L., Gonzalez-Chica, D., Adams, R., Achoki, T., Shi, Z., & Renzaho, A. (2018). Trends of mortality attributable to child and maternal undernutrition, overweight/obesity and dietary risk factors of non-communicable diseases in sub-Saharan Africa, 1990–2015: findings from the Global Burden of Disease Study 2015. Public Health Nutrition, 22(5), 827–840. https://doi.org/10.1017/s1368980018002975
Mirzabaev, A., Olsson, L., Kerr, R. B., Pradhan, P., Ferre, M. G. R., & Lotze-Campen, H. (2023). Climate Change and Food Systems. In: Science and Innovations for Food Systems Transformation. Springer International Publishing. 511-529. https://doi.org/10.1007/978-3-031-15703-5_27
Nilsson, M., Sie, A., Muindi, K., Bunker, A., Ingole, V., & Ebi, K. L. (2021). Weather, climate, and climate change research to protect human health in sub-Saharan Africa and South Asia. Global Health Action, 14(Suppl. 1). https://doi.org/10.1080/16549716.2021.1984014
Ndlovu, N., & Chungag, B. N. (2024). Impact of heat stress on cardiovascular health outcomes of older adults: A mini review. Aging and Health Research, 4(2), 100189. https://doi.org/10.1016/j.ahr.2024.100189
Ogony, J., Mangeni, J., Ayodo, G., et al. (2025). The stifling burden of climate change on African public healthcare systems. Frontiers in Public Health, 13. https://doi.org/10.3389/fpubh.2025.1559737
Pandey, A., Brauer, M., Cropper, M. L., et al. (2020). Health and economic impact of air pollution in the states of India: the Global Burden of Disease Study 2019. The Lancet Planetary Health, 5(1), e25-e38. https://doi.org/10.1016/S2542-5196(20)30298-9
Poddar, P., Banavaram, A. A., Ramanaik, S., Jayabalan, M., & Vismaya, S. (2025). How city living affects mental health-a qualitative exploration of urban stressors among adults in a megacity in India. BMC Public Health, 25(1), 1597. https://doi.org/10.1186/s12889-025-22817-x
Romanello, M., Napoli, C.D., Green, C., et al. (2023). The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms. The Lancet, 402(10419), 2346-2394. https://doi.org/10.1016/s0140-6736(23)01859-7
Romanello, M., Walawender, M., Hsu Shih-Che, et al., (2024). The 2024 report of the Lancet Countdown on health and climate change: facing record-breaking threats from delayed action. The Lancet, 404(10465), 1847-1896. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01822-1/abstract [Last accessed on 2026 Mar 20].
Sahu, S., Kumar, S., Nagtode, N. R., & Sahu, M. (2024). “The burden of lifestyle diseases and their impact on health service in India”—A narrative review. Journal of Family Medicine and Primary Care, 13(5), 1612-1619. https://doi.org/10.4103/jfmpc.jfmpc_693_23
Salvi, S., Kumar, G. A., Dhaliwal, R. S., et al. (2018). The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990–2016. The Lancet Global Health, 6(12), e1363-e1374. https://doi.org/10.1016/s2214-109x(18)30409-1
Sathishkumar, K., Chaturvedi, M., Das, P., Stephen, S., & Mathur, P. (2022). Cancer incidence estimates for 2022 & projection for 2025: Result from National Cancer Registry Programme, India. The Indian Journal of Medical Research, 156(4-5), 598-607. ncbi. https://doi.org/10.4103/ijmr.ijmr_1821_22
Savage, A., McIver, L., & Schubert, L. (2020). Review: the nexus of climate change, food and nutrition security and diet-related non-communicable diseases in Pacific Island Countries and Territories. Climate and Development, 12(2), 120–133. https://doi.org/10.1080/17565529.2019.1605284
Sesay, U., & Osborne, A. (2025). Building climate-resilient health systems in Sierra Leone: addressing the dual burden of infectious and climate-related diseases. Infectious Diseases of Poverty, 14(1). https://doi.org/10.1186/s40249-025-01294-9
Siiba, A., Kangmennaang, J., Baatiema, L., & Luginaah, I. (2024). The relationship between climate change, globalization and non-communicable diseases in Africa: A systematic review. PLOS One, 19(2), e0297393. https://doi.org/10.1371/journal.pone.0297393
Singh, N., Areal, A. T., Breitner, S., Zhang, S., Agewall, S., Schikowski, T., & Schneider, A. (2024). Heat and Cardiovascular Mortality: An Epidemiological Perspective. Circulation Research, 134(9), 1098–1112. https://doi.org/10.1161/circresaha.123.323615
Skevaki, C., Nadeau, K. C., Rothenberg, M. E., Alahmad, B., Mmbaga, B. T., Masenga, G. G., Sampath, V., Christiani, D. C., Haahtela, T., & Renz, H. (2024). Impact of climate change on immune responses and respiratory allergies. Journal of Allergy and Clinical Immunology, 153(5), 1194-1205. https://doi.org/10.1016/j.jaci.2024.01.016
Sutanto, H. (2024). Intersecting Crises: Exploring the Impact of Climate Change on the Burgeoning Burden of Noncommunicable Diseases. Preprints. https://doi.org/10.20944/preprints202402.1444.v1
Taha, T. (2016). Climate change and potential impact on disease: What are the public health agenda? Saudi Journal of Medicine and Medical Sciences, 4(2), 71. https://doi.org/10.4103/1658-631x.178285
United Nations Office for Disaster Risk Reduction. (2021, July 12). Global Assessment Report on Disaster Risk Reduction (GAR). Available from: https://www.undrr.org/gar/gar2025 [Last accessed on 2026 Mar 20].
Walinski, A., Sander, J., Gerlinger, G., Clemens, V., Meyer-Lindenberg, A., & Heinz, A. (2023). The Effects of Climate Change on Mental Health. Deutsches Arzteblatt International, 120(8), 117-124. https://doi.org/10.3238/arztebl.m2022.0403
World Health Organization. (2021). Climate change and health vulnerability and adaptation assessment. (n.d.). Available from: https://iris.who.int/server/api/core/bitstreams/6edda8d7-451e-4edc-b096-c84d76e1355b/content [Last accessed on 2026 Mar 20].
World Health Organization. (2023). Climate change and noncommunicable diseases: connections. Available from: https://www.who.int/news/item/02-11-2023-climatechange-and-noncommunicable-diseases-connections [Last accessed on 2026 Jan 30].
World Health Organization. (2024a). Fifth Global School On Refugee And Migrant Health- Advancing universal health coverage for refugees and migrants: from evidence to action. Available from: https://cdn.who.int/media/docs/default-source/documents/health-topics/refugee-and-migrant-health/5th-global-school-report.pdf?sfvrsn=67625882_14&download=true [Last accessed on 2026 Mar 20].
World Health Organization. (2024b). Global Cancer Burden growing, Amidst Mounting Need for Services. Available from: https://www.who.int/news/item/01-02-2024-globalcancer-burden-growing--amidst-mounting-need-forservices [Last accessed on 2026 Mar 20].
World Health Organization. (2025a). Noncommunicable diseases. Available from: https://www.who.int/newsroom/fact-sheets/detail/noncommunicable-diseases [Last accessed on 2026 Mar 20].
World Health Organization. (2025b). Ending disease in Africa-Responding to communicable and noncommunicable diseases: Progress report 2020-2022. (2023). Available from: https://www.afro.who.int/sites/default/files/2023-08/Ending%20disease%20in%20Africa_Progress%20report.pdf [Last accessed on 2026 Mar 20].
World Health Organization. (2025c). No health without inclusion: Leaders call for equitable action on noncommunicable diseases for migrants and refugees at WHA78. Available from: https://www.who.int/news/item/20-05-2025-no-health-without-inclusion--leaderscall-for-equitable-action-on-noncommunicable-diseasesfor-migrants-and-refugees-at-wha78 [Last accessed on 2026 Mar 20].
World Health Organization. (2025d). Thematic Dialogue Series on Non-Communicable Diseases and Mental Health: Environmental Risk Factors for NCDs and Mental Health. Available from: https://www.who.int/publications/m/item/thematic-dialogue-series-on-non-communicable-diseasesand-mental-health--environmental-risk-factors-for-ncdsand-mental-health [Last accessed on 2026 Mar 20].
