AccScience Publishing / EJMO / Online First / DOI: 10.36922/EJMO026030034
LETTER TO EDITOR

Metabolic reprogramming: A key mechanism underlying chemotherapy resistance in non-small cell lung cancer

Chenchen Zhao1† Tong Wu2† Zhuting Li1* Xianbin Kong3*
Show Less
1 Department of Oncology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Hebei, Tianjin, China
2 Department of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Hebei, Tianjin, China
3 Tianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Jinghai, Tianjin, China
†These authors contributed equally to this work.
Received: 16 January 2026 | Accepted: 19 January 2026 | Published online: 20 February 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Funding
This work was supported by the Science and Technology Development Fund of Tianjin Education Commission for Higher Education (Grant no: 2022KJ180).
Conflict of interest
Xianbin Kong is an Editorial Board Member of this journal but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, other authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
References
  1. Peixoto BP, Clague RA, Reddy JP, Wettersten HI. The emerging roles of metabolic reprogramming in non-small cell lung cancer progression. Front Biosci (Landmark Ed). 2025;30(7):31363. doi: 10.31083/fbl31363

 

  1. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 2009;324(5930):1029-1033. doi: 10.1126/science.1160809

 

  1. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004;4(11):891-899. doi: 10.1038/nrc1478

 

  1. Weinberg F, Hamanaka R, Wheaton WW, et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 2010;107(19):8788-8793. doi: 10.1073/pnas.1003428107

 

  1. Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23(1):27-47. doi: 10.1016/j.cmet.2015.12.006

 

  1. Zhao C, Wu T, Kong X, Li Z. Application of natural killer cell-based immunotherapy in lung cancer treatment. Eurasian J Med Oncol. 2025;9:35-48. doi: 10.36922/ejmo025110051

 

  1. Sun X, Zhao P, Li H, Liu Y, Wang T, Cheng Y. Ginsenoside Rh2 inhibits glycolysis through the STAT3/c-MYC axis in non-small-cell lung cancer. J Oncol. 2021;2021:9715154. doi: 10.1155/2021/9715154
Share
Back to top
Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing