AccScience Publishing / EJMO / Online First / DOI: 10.36922/ejmo.8404
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ORIGINAL RESEARCH ARTICLE

A novel ultraviolet-associated gene signature to predict prognosis and immunological features in patients with skin melanoma

Xiaoyun Jiang1 ,  Defeng Kong1 ,  Hao Cheng1*
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1 Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
EJMO, 8404 https://doi.org/10.36922/ejmo.8404
Received: 4 January 2025 | Revised: 30 April 2025 | Accepted: 8 May 2025 | Published online: 29 May 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Introduction: Research on the impact of ultraviolet (UV)-related genes on the prognosis of melanoma is rare. Objective: This study aimed to explore the role of UV-associated genes in skin melanoma and their impact on prognosis. Methods: We evaluated the prognostic implications of UV-associated genes in cutaneous melanoma and developed a predictive model for patient outcomes utilizing skin melanoma datasets sourced from The Cancer Genome Atlas. Subsequently, we investigated the correlation between UV-associated genes and the local immune environment within cutaneous melanoma. Results: The developed prognostic model for cutaneous melanoma holds significant value for clinicians in assessing patient outcomes. The expression levels of UV-associated genes appear to influence the infiltration degree of various immune cells within the tumor microenvironment, including T cells and M1 macrophages. In addition, the model was able to predict melanoma prognosis and stratify melanoma patients, with patients in the high-risk group having a worse prognosis. Results also indicated that the high-risk group exhibited reduced infiltration of cytotoxic immune cells in the tumor tissue than the low-risk group. Conclusion: The findings from this novel study have the potential to identify new therapeutic targets in treating cutaneous melanoma.

Keywords
Ultraviolet-associated genes
Skin melanoma
Prognosis
Immune infiltration
Drug prediction
Funding
This work was supported by the National Natural Science Foundation of China (Grant number: 82373491).
Conflict of interest
The authors declare that they have no competing interests.
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Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing
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