Research progress of ferroptosis and urinary tumors
Since the researchers discovered ferroptosis in 2012, they have conducted in-depth research and exploration on the mechanism of ferroptosis and its role in tumor evolution. ferroptosis is a new type of death that is different from apoptosis and necrosis. It is mainly dependent on the cell death caused by the increase of iron and lipid oxygen in the cell and the imbalance of redox homeostasis. After the development of urinary tumors in the middle and late stage, most patients have poor surgical results. Chemotherapy is usually given after surgery. However, some tumor cells are currently resistant to chemotherapy drugs. Therefore, the occurrence of ferroptosis increases a new idea in the treatment of urinary tumors. The purpose of this review is to outline the knowledge of ferroptosis mechanisms and regulation, its role in the growth and proliferation of urinary tumor cells, and to provide new strategies for the treatment of urological tumor diseases.
Li YQ, Yang M, Li XT, 2018, Biochemical Processes of Ferroptosis and its Effects on Tumors. Chin J Biochem Mol Biol, 34:838–43.
Ashmore JH, Rogers CJ, Kelleher SL, et al., 2016, Dietary Iron and Colorectal Cancer Risk: A Review of Human Population Studies. Crit Rev Food Sci Nutr, 56:1012–20. DOI: 10.1080/10408398.2012.749208.
Bystrom LM, Rivella S, 2015, Cancer Cells with Irons in the Fire. Free Radic Biol Med, 79:337–42. DOI: 10.1016/j.freeradbiomed.2014.04.035.
Dolma S, Lessnick SL, Hahn WC, et al., 2003, Identification of Genotype-selective Antitumor Agents using Synthetic Lethal Chemical Screening in Engineered Human Tumor Cells. Cancer Cell, 3:285–96. DOI: 10.1016/S1535-6108(03)00050-3.
Yang WS, Stockwell BR, 2008, Synthetic Lethal Screening Identifies Compounds Activating Iron-dependent, Nonapoptotic Cell Death in Oncogenic-RAS-harboring Cancer Cells. Chem Biol, 15:234–45. DOI: 10.1016/j.chembiol.2008.02.010.
Dixon SJ, Lemberg KM, Lamprecht MR, et al., 2012, Ferroptosis: An Iron-dependent form of Nonapoptotic Cell Death. Cell, 149:1060–72. DOI: 10.1016/j.cell.2012.03.042.
Louandre C, Ezzoukhry Z, Godin C, et al., 2013, Iron-dependent Cell Death of Hepatocellular Carcinoma Cells Exposed to Sorafenib. Int J Cancer, 133:1732–42. DOI: 10.1002/ijc.28159.
Abrams RP, Carroll WL, Woerpel KA, 2016, Five-membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells. ACS Chem Biol, 11:1305–12. DOI: 10.1021/acschembio.5b00900.
Bridges RJ, Natale NR, Patel SA, 2012, System xc-cystine/Glutamate Antiporter: An Update on Molecular Pharmacology and Roles within the CNS. Br J Pharmacol, 165:20–34. DOI: 10.1111/j.1476-5381.2011.01480.x.
Yu H, Guo P, Xie X, et al, 2017, Ferroptosis, a New form of Cell Death, and its Relationships with Tumourous Diseases. J Cell Mol Med, 21:648–57. DOI: 10.1111/jcmm.13008.
Ursini F, Maiorino M, Brigelius-Flohé R, et al., 1995, Diversity of Glutathione Peroxidases. Methods Enzymol, 252:38–53. DOI: 10.1016/0076-6879(95)52007-4.
Yang WS, SriRamaratnam R, Welsch ME, et al., 2014, Regulation of Ferroptotic Cancer Cell Death by GPX4. Cell, 156:317–31. DOI: 10.1016/j.cell.2013.12.010.
Yang WS, Shimada K, Delva D, et al., 2012, Identification of Simple Compounds with Microtubule-binding Activity that Inhibit Cancer Cell Growth with High Potency. ACS Med Chem Lett, 3:35–8. DOI: 10.1021/ml200195s.
Zhou WB, Kong CF, Qin GW, et al., 2018, Research Progress on the Mechanism of Ferroptosis. Prog Biochem Biophys, 45:16–22.
Jiang L, Kon N, Li T, et al., 2015, Ferroptosis as a p53-mediated Activity During Tumour Suppression. Nature, 520:57–62. DOI: 10.1038/nature14344.
Yang WS, Stockwell BR, 2016, Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol, 26:165–76.DOI: 10.1016/j.tcb.2015.10.014.
Friedmann AJP, Schneider M, Proneth B, et al., 2014, Inactivation of the Ferroptosis Regulator Gpx4 Triggers Acute Renal Failure in Mice. Nat Cell Biol, 16:1180–91. DOI 10.1038/ncb3064.
Maiuri MC, Zalckvar E, Kimchi A, et al., 2007, Self-eating and Self-killing: Crosstalk between Autophagy and Apoptosis. Nat Rev Mol Cell Biol, 8:741–52. DOI: 10.1038/nrm2239.
Ding K, Wang HD, 2014, Advances in Research on the Role of Autophagy in Traumatic Brain Injury. Southeast Natl Def Med, 16:181–3.
Yazdi AS, Guarda G, D’Ombrain MC, et al. Inflammatory Caspases in Innate Immunity and Inflammation. J Innate Immun, 2:228–37. DOI: 10.1159/000283688.
Warner GJ, Berry MJ, Moustafa ME, et al., 2000, Inhibition of Selenoprotein Synthesis by Selenocysteine tRNA[Ser]Sec Lacking Isopentenyladenosine. J Biol Chem, 275:28110–9. DOI: 10.1074/jbc.M001280200.
McBean GJ, 2012, The Transsulfuration Pathway: A Source of Cysteine for Glutathione in Astrocytes. Amino Acids, 42:199–205. DOI: 10.1007/s00726-011-0864-8.
Hayano M, Yang WS, Corn CK, et al., 2016, Loss of Cysteinyl-tRNA Synthetase (CARS) Induces the Transsulfuration Pathway and Inhibits Ferroptosis Induced by Cystine Deprivation. Cell Death Differ, 23:270–8. DOI: 10.1038/cdd.2015.93.
Sun X, Ou Z, Xie M, et al., 2015, HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death. Oncogene, 34:5617–25. DOI: 10.1038/onc.2015.32.
Hasegawa M, Takahashi H, Rajabi H, et al., 2016, Functional Interactions of the Cystine/glutamate Antiporter, CD44v and MUC1-C Oncoprotein in Triple-negative Breast Cancer Cells. Oncotarget, 7:11756–69. DOI: 10.18632/oncotarget.7598.
Ma S, Henson ES, Chen Y, et al., 2016, Ferroptosis is Induced following Siramesine and Lapatinib Treatment of Breast Cancer Cells. Cell Death Dis, 7:e2307. DOI :10.1038/cddis.2016.208.
Lőrincz T, Jemnitz K, Kardon T, et al., 2015, Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathol Oncol Res, 21:1115–21. DOI: 10.1007/s12253-015-9946-3.
Torii S, Shintoku R, Kubota C, et al., 2016, An Essential Role for Functional Lysosomes in Ferroptosis of Cancer Cells. Biochem J, 473:769–77. DOI: 10.1042/BJ20150658.
Ma ZH, Lian M, Ci S, et al., 2018, Research Progress on Iron Death and Tumor. J Clin Exp Pathol, 34:1247–51.
Garg JP, Vucic D, 2016, Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases. Semin Nephrol, 36:153–61. DOI: 10.1016/j.semnephrol.2016.03.003.
Jiang X, Zhang C, Qi S, et al., 2016, Elevated Expression of ZNF217 Promotes Prostate Cancer Growth by Restraining Ferroportin-conducted Iron Egress. Oncotarget, 7:84893–906. DOI: 10.18632/oncotarget.12753.
Simões RV, Veeraperumal S, Serganova IS, et al., 2017, Inhibition of Prostate Cancer Proliferation by Deferiprone. NMR Biomed, 30:167–78. DOI: 10.1002/nbm.3712.
Seligman PA, Schleicher RB, Siriwardana G, et al., 1993, Effects of Agents that Inhibit Cellular Iron Incorporation on Bladder Cancer Cell Proliferation. Blood, 82(5):1608–17.
Dayani PN, Bishop MC, Black K, et al., 2004, Desferoxamine (DFO)-mediated Iron Chelation: Rationale for a Novel Approach to Therapy for Brain Cancer. J Neurooncol, 67:367–77. DOI: 10.1023/B: NEON.0000024238.21349.37.
Mazdak H, Yazdekhasti F, Movahedian A, et al, The Comparative Study of Serum Iron, Copper, and Zinc Levels between Bladder Cancer Patients and a Control Group. Int Urol Nephrol, 42:89–93. DOI: 10.1007/s11255-009-9583-4.