The Effects of Sevoflurane in the Progression of Solid Tumors Based on the Evidence of Preclinical Studies
Sevoflurane is a widely used volatile anesthetic in clinical treatment. Recently, the effect of sevoflurane on tumor cell signaling pathways has attracted the attention of many researchers in the field. However, the underlying mechanism behind the effect of sevoflurane on tumor cell signaling pathways still remains unclear. Based on the evidence of in vitro experiments, this paper reviews the recent research results on the sevoflurane-mediated regulation on solid tumors and presents its potential molecular mechanisms that can provide references for clinical practices.
Tohme S, Simmons RL, Tsung A, 2017, Surgery for Cancer: A Trigger for Metastases. Cancer Res, 77:1548–52. DOI: 10.1158/0008-5472.CAN-16-1536.
Kim R, 2017, Anesthetic Technique and Cancer Recurrence in Oncologic Surgery: Unraveling the Puzzle. Cancer Metastasis Rev, 36:159–77. DOI: 10.1007/s10555-016-9647-8.
Bovill JG, 2010, Surgery for Cancer: Does Anesthesia Matter? Anesth Analg, 110:1524–6. DOI: 10.1213/ANE.0b013e3181d8d183.
Gottschalk A, Sharma S, Ford J, et al., 2010, Review Article: The Role of the Perioperative Period in Recurrence after Cancer Surgery. Anesth Analg, 110:1636–43. DOI: 10.1213/ANE.0b013e3181de0ab6.
Liang H, Gu M, Yang C, et al., 2011, Sevoflurane Inhibits Proliferation, Induces Apoptosis, and Blocks Cell Cycle Progression of Lung Carcinoma Cells. Asian Pac J Cancer Prev, 12:3415–20.
Liang H, Gu M, Yang C, et al., 2012, Sevoflurane Inhibits Invasion and Migration of Lung Cancer Cells by Inactivating the p38 MAPK Signaling Pathway. J Anesth, 26:381–92. DOI: 10.1007/s00540-011-1317-y.
Liang H, Yang CX, Zhang B, et al., 2015, Sevoflurane Suppresses Hypoxia-induced Growth and Metastasis of Lung Cancer Cells Via Inhibiting Hypoxia-Inducible Factor-1a. J Anesth, 29:821–30. DOI: 10.1007/s00540-015-2035-7.
Liang H, Wang HB, Liu HZ, et al., 2013, The Effects of Combined Treatment with Sevoflurane and Cisplatin on Growth and Invasion of Human Adenocarcinoma Cell Line A549. Biomed Pharmacother, 67:503–9. DOI: 10.1016/j.biopha.2013.03.005.
Su G, Yan Z, Deng M, 2020, Sevoflurane Inhibits Proliferation, Invasion, but Enhances Apoptosis of Lung Cancer Cells by Wnt/b-catenin Signaling via Regulating lncRNA PCAT6/miR-326 axis. Open Life Sci, 15:159–72. DOI: 10.1515/biol-2020-0017
Kim Y, Yun S, Shin K, et al., 2021, Effects of Sevoflurane on Lewis Lung Carcinoma Cell Proliferation In Vivo and In Vitro. Medicina, 57(1):45. DOI: 10.3390/medicina57010045
Freddie B, Ferlay J, Soerjomataram I, et al., 2018, Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 68:394–424. DOI: 10.3322/caac.21492.
Deegan CA, Murray D, Doran P, et al., 2009, Effect of Anaesthetic Technique on Oestrogen Receptor-negative Breast Cancer Cell Function In Vitro. Br J Anaesth, 103:685–90.
Deegan CA, Murray D, Doran P, et al., 2010, Anesthetic Technique and the Cytokine and Matrix Metalloproteinase Response to Primary Breast Cancer Surgery. Reg Anesth Pain Med, 35:490–5.
Lim J, Oh C, Yoon T, et al., 2018, The Effect of Propofol and Sevoflurane on Cancer Cell, Natural Killer Cell, and Cytotoxic T Lymphocyte Function in Patients Undergoing Breast Cancer Surgery: An In Vitro Analysis. BMC Cancer, 18:159. DOI: 10.1186/s12885-018-4064-8.
Huitink JM, Heimerikxs M, Nieuwland M, et al., 2010, Volatile Anesthetics Modulate Gene Expression in Breast and Brain Tumor Cells. Anesth Analg, 111:1411–5. DOI: 10.1213/ANE.0b013e3181fa3533.
Jaura AI, Flood G, Gallagher HC, et al., 2014, Differential Effects of Serum from Patients Administered Distinct Anaesthetic Techniques on Apoptosis in Breast Cancer Cells In Vitro: A Pilot Study. Br J Anaesth, 113:i63–7. DOI: 10.1093/bja/aet581.
Deng X, Vipani M, Liang G, et al., 2020, Sevoflurane Modulates Breast Cancer Cell Survival Via Modulation of Intracellular Calcium Homeostasis. BMC Anesthesiol, 20:253.
Wu T, Sun L, Wang C, et al., 2021, Sevoflurane Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Breast Cancer Cells Through the miR-139-5p/ARF6 Axis. J Surg Res, 258:314–23.
Ecimovic P, McHugh B, Murray D, et al., 2013, Effects of Sevoflurane on Breast Cancer Cell Function In Vitro. Anticancer Res, 33:4255–60.
Tiron CE, Patrașcanu E, Postu PA, et al., 2021, Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study. Curr Issues Mol Biol, 43:264–75. DOI: 10.3390/cimb43010022.
Lihua F, Yini W, Wang J, et al., 2019, Sevoflurane Inhibits the Migration and Invasion of Colorectal Cancer Cells through Regulating ERK/MMP-9 Pathway by up-regulating miR-203. Eur J Pharmacol, 850:43–52. DOI: 10.1016/j.ejphar.2019.01.025.
Muller-Edenborn B, Roth-Z’Graggen B, Bartnicka K, et al., 2012, Volatile Anesthetics Reduce Invasion of Colorectal Cancer Cells through Down-regulation of Matrix Metalloproteinase-9. Anesthesiology, 117:293–301. DOI: 10.1097/ALN.0b013e3182605df1.
Sun SQ, Ren LJ, Liu J, et al., 2019, Sevoflurane Inhibits Migration and Invasion of Colorectal Cancer Cells by Regulating MicroRNA-34a/ADAM10 axis. Neoplasma, 66:887–95. DOI: 10.4149/neo_2018_181213N962.
Hu N, Duan J, Yu Y, et al., 2021, Sevoflurane Inhibits the Migration, Invasion and Induces Apoptosis by Regulating the Expression of WNT1 via miR-637 in Colorectal Cancer. Anticancer Drugs, 32:537–547. DOI: 10.1097/CAD.0000000000001061.
Wang J, Li S, Zhang G, et al., 2021, Sevoflurane Inhibits Malignant Progression of Colorectal Cancer Via hsa_circ_0000231-mediated miR-622. J Biol Res (Thessalon), 28:14. DOI: 10.1186/s40709-021-00145-6.
Zhao H, Xing F, Yuan J, et al., 2020, Sevoflurane Inhibits Migration and Invasion of Glioma Cells Via Regulating miR-34a-5p/MMP-2 axis. Life Sci, 256:117897. DOI: 10.1016/j.lfs.2020.117897.
Shi QY, Zhang SJ, Liu L, et al., 2015, Sevoflurane Promotes the Expansion of Glioma Stem Cells through Activation of Hypoxia-inducible Factors In Vitro. Br J Anaesth, 114:825–30. DOI: 10.1093/bja/aeu402.
Han X, Zhang Y, Dong X, et al., 2020, Sevoflurane Modulates the Cancer Stem Cell-Like Properties and Mitochondrial Membrane Potential of Glioma via Ca2+-dependent CaMKII/JNK Cascade. Life Sci, 253:117675. DOI: 10.1016/j.lfs.2020.117675.
Hurmath FK, Mittal M, Ramaswamy P, et al., 2016, Sevoflurane and Thiopental Preconditioning Attenuates the Migration and Activity of MMP-2 in U87MG Glioma Cells. Neurochem Int, 94:32–8. DOI: 10.1016/j.neuint.2016.02.003.
Zhang L, Wang J, Fu Z, et al., 2019, Sevoflurane Suppresses Migration and Invasion of Glioma Cells by Regulating miR-146b-5p and MMP16. Artif Cells Nanomed Biotechnol, 47:3306–14. DOI: 10.1080/21691401.2019.1648282
Yi W, Li D, Guo Y, et al., 2016, Sevoflurane Inhibits the Migration and Invasion of Glioma Cells by Upregulating MicroRNA-637. Int J Mol Med, 38:1857–63.
Wen J, Ding Y, Zheng S, et al., 2020, Sevoflurane Suppresses Glioma Cell Proliferation, Migration, and Invasion Both In Vitro and In Vivo Partially Via RegulatingKCNQ1OT1/miR-146b-5p/STC1 Axis. Cancer Biother Radiopharm, ahead of print. DOI: 10.1089/cbr.2020.3762.
Xu W, Xue R, Xia R, et al., 2020, Sevoflurane Impedes the Progression of Glioma through Modulating the Circular RNA has_circ_0012129/miR-761/TGIF2 axis. Eur Rev Med Pharmacol Sci, 24:5534–48. DOI: 10.26355/eurrev_202005_21339.
Li H, Xia T, Guan Y, et al., 2020, Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis. Cancer Manag Res, 12:5085–98. DOI: 10.2147/CMAR.S242135.
Gao C, Shen J, Meng Z, et al., 2020, Sevoflurane Inhibits Glioma Cells Proliferation and Metastasis through miRNA-124-3p/ROCK1 Axis. Pathol Oncol Res, 26:947–54. DOI: 10.1007/s12253-019-00597-1.
Gao Y, Ma H, Hou D, 2020, Sevoflurane Represses Proliferation and Migration of Glioma Cells by Regulating the ANRIL/let-7b-5p Axis. Cancer Biother Radiopharm, ahead of print. DOI: 10.1089/cbr.2020.3596.
Bao X, Peng Y, Shen J, et al., 2021, Sevoflurane Inhibits Progression of Glioma Via Regulating the HMMR Antisense RNA 1/microRNA-7/cyclin Dependent Kinase 4 Axis. Bioengineered, 12:7893–906. DOI: 10.1080/21655979.2021.1976712.
Zhao Z, Gao B, Zong X, et al., 2021, Sevoflurane Impedes Glioma Progression Via Regulating circ_0000215/miR-1200/NCR3LG1 axis. Metab Brain Dis, 36:2003–14. DOI: 10.1007/s11011-021-00817-1.
Zhan X, Lei C, Yang L, 2021, Sevoflurane Inhibits Cell Proliferation and Migration of Glioma by Targeting the miR27b/VEGF axis. Mol Med Rep, 23:408. DOI: 10.3892/mmr.2021.12047.
Ishikawa M, Iwasaki M, Zhao H, et al., 2021, Inhalational Anesthetics Inhibit Neuroglioma Cell Proliferation and Migration via miR-138, -210 and -335. Int J Mol Sci, 22:4355.DOI: 10.3390/ijms22094355.
Kang X, Li H, Zhang Z, 2021, Sevoflurane Blocks Glioma Malignant Development by Upregulating circRELN through circRELN-mediated miR-1290/RORA axis. BMC Anesthesiol, 21:213. DOI: 10.1186/s12871-021-01427-1.
Qi Y, Guo L, Liu Y, et al., 2021, Sevoflurane Limits Glioma Progression by Regulating Cell Proliferation, Apoptosis, Migration, and Invasion via miR-218-5p/DEK/b-Catenin Axis in Glioma. Cancer Manag Res, 13:2057–69. DOI: 10.2147/CMAR.S265356.
Cheng S, Cheng J, 2021, Sevoflurane Suppresses Glioma Tumorigenesis via Regulating circ_0079593/miR-633/ROCK1 axis. Brain Res, 1767:147543. DOI: 10.1016/j.brainres.2021.147543.
Gao C, He X, Xu Q, et al., 2019, Sevoflurane Downregulates Insulin-like Growth Factor-1 to Inhibit Cell Proliferation, Invasion and Trigger Apoptosis in Glioma through the PI3K/AKT Signaling Pathway. Anticancer Drugs, 30:670–6. DOI: 10.1097/CAD.0000000000000744.
Nishiwada T, Kawaraguchi Y, Uemura K, et al., 2015, Effect of Sevoflurane on Human Hepatocellular Carcinoma HepG2 Cells under Conditions of High Glucose and Insulin. J Anesth, 29:805–8. DOI: 10.1007/s00540-015-2025-9.
Fu X, Wen H, Jing L, et al., 2017, MicroRNA‐155‐5p Promotes Hepatocellular Carcinoma Progression by Suppressing PTEN through the PI3K/Akt Pathway. Cancer Sci, 108:620–31. DOI: 10.1111/cas.13177.
Song G, Tian L, Cheng Y, et al., 2019, Antitumor Activity of Sevoflurane in HCC Cell Line is Mediated by miR‐29a‐induced Suppression of Dnmt3a. J Cell Biochem, 120:18152–61. DOI: 10.1002/jcb.29121.
Cao Y, Lv W, Ding W, et al., 2020, Sevoflurane Inhibits the Proliferation and Invasion of Hepatocellular Carcinoma Cells through Regulating the PTEN/Akt/GSK3b/bcatenin Signaling Pathway by Downregulating miR253p. Int J Mol Med, 46:97–106. DOI: 10.3892/ijmm.2020.4577.
Zhou W, Li H, Shang S, et al., 2021, lncRNA KCNQ1OT1 Reverses the Effect of Sevoflurane on Hepatocellular Carcinoma Progression Via Regulating the miR-29a-3p/CBX3 Axis. Braz J Med Biol Res, 54:e10213. DOI: 10.1590/1414-431X2020e10213.
