AccScience Publishing / IJB / Online First / DOI: 10.36922/IJB025320322
REVIEW ARTICLE
Early Access

Recent development of 3D printing hydrogel for treatment of diabetic wound

Mengdi Yin1† Yutong Wang2† Yuhang Wei2† Changjia Li3 Yiqiao Yin2 Tiantang Fan2* Peixin Wang1*
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1 Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, China
2 College of Medical Engineering and the Key Laboratory for Medical Functional Nanomaterials, Jining Medical University, Jining, Shandong, China
3 Department of Colorectal and Anal Surgery, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group). Qingdao, Shandong, China
†These authors contributed equally to this work.
Received: 10 August 2025 | Accepted: 15 September 2025 | Published online: 18 September 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Diabetic wound healing disorder was one of the common complications in diabetic patients, which was characterized by persistent chronic inflammation, impaired angiogenesis, abnormal remodeling of extracellular matrix (ECM), and significantly increased oxidative stress level. Although the traditional treatment models have achieved some success, it still faced the challenges of prolonged wound healing time, increased risk of infection, and continuous formation of scar tissue, especially in gastrointestinal surgical incisions, orthopedic surgical incisions, and neurosurgical surgical incisions. In recent years, the integration of biomaterials and advanced manufacturing technologies brought new opportunities for diabetic wound repair. Hydrogels have gained more attention due to the excellent biocompatibility, degradability, and significant wound repair ability. As an emerging advanced manufacturing method, 3D printing technology could accurately fabricate hydrogels according to the shape and size of the wound, providing an ideal microenvironment for wound repair. In this review, we systematically reviewed the latest research of 3D printed hydrogels in diabetic wound repair in the past five years, and deeply discussed the preparation methods, including physical, chemical, and biological cross-linking methods, and the specific mechanisms of promoting wound healing, such as regulating inflammatory response, promoting angiogenesis, and guiding the normal remodeling of ECM. This review aimed to provide a solid theoretical and experimental basis for the continued development and eventual clinical application of 3D printed hydrogels for diabetic wounds.

Keywords
3D printed hydrogel
Surgical incision
Diabetic wound
Preparation method
Mechanism
Funding
This work was supported by the Research Fund for Academician Lin He New Medicine.
Conflict of interest
The authors declare they have no competing interests.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing