AccScience Publishing / IJB / Online First / DOI: 10.36922/IJB025170164
REVIEW ARTICLE
Early Access

Artificial intelligence in advancing sustainability in bioprinting

Hongyi Chen1,2* Jie Huang2
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1 Department of Computer Science, University College London, London, UK
2 Department of Mechanical Engineering, University College London, London, UK
Received: 24 April 2025 | Accepted: 1 July 2025 | Published online: 10 July 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Sustainable bioprinting is a transformative approach in tissue engineering and regenerative medicine, offering solutions to environmental challenges while advancing functional outcomes. Yet, achieving true sustainability remains complex, requiring reductions in material waste and energy use, and scalable, resource-efficient fabrication without compromising biological performance. Artificial intelligence (AI) provides a powerful means to meet these demands through data-driven material design, predictive process optimization, and intelligent control systems that improve both efficiency and environmental impact across the bioprinting workflow. This review examines the integration of AI into sustainable bioprinting across four key areas: hydrogel material discovery and development, bioink screening, process parameter optimization, and AI-assisted intelligent printing. AI facilitates the design of eco-friendly hydrogels by predicting molecular interactions and tailoring structural properties. It also improves bioink formulation by optimizing printability, biocompatibility, and mechanical strength, thereby reducing reliance on resource-intensive trial-and-error experimentation. Furthermore, AI algorithms streamline workflows by dynamically adjusting printing parameters to improve fidelity and reduce waste, while advanced AI-assisted systems demonstrate the feasibility of multi-material, contactless bioprinting aligned with sustainability goals.

Keywords
Bioprinting
Sustainability
Artificial intelligence
Biomaterials
Funding
No funding was received
Conflict of interest
The authors declare no conflicts of interest
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing