AccScience Publishing / IJB / Volume 8 / Issue 2 / DOI: 10.18063/ijb.v8i2.552
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REVIEW

Application of Bioprinting in Ophthalmology

Yanfang Wang1,2,3† Jiejie Wang4† Ziyu Ji5† Wei Yan6 Hong Zhao7 Wenhua Huang2,3,4* Huan Liu8*
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1 Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing, 400045, China
2 Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
3 Guangdong Innovation Platform for Translation of 3D Printing Application, The third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
4 Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
5 College of Integrated Chinese and Western Medicine, Southwest Medical University, Lu Zhou 646000, China
6 Department of Anatomy, Hebei Medical University, Shijiazhuang 050011, China
7 School of Basic Medicine, Guangdong Medical University, Dongguan, Guangdong 523000, China
8 National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
Submitted: 15 December 2021 | Accepted: 22 February 2022 | Published: 22 February 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Three-dimensional (3D) bioprinting is an emerging technology that is widely used in regenerative medicine. With the continuous development of the technology, it has attracted great attention and demonstrated promising prospects in ophthalmologic applications. In this paper, we review the three main types of 3D bioprinting technologies: Vat polymerizationbased bioprinting, extrusion-based bioprinting, and jetting-based bioprinting. We also present in this review the analysis of the usage of both natural and synthesized hydrogels as well as the types of cells adopted for bioinks. Cornea and retina are the two main types of ocular tissues developed in bioprinting, while other device and implants were also developed for the ocular disease treatment. We also summarize the advantages and limitations as well as the future prospects of the current bioprinting technologies based on systematic reviews.

Keywords
Bioprinting
Ophthalmology
Bioinks
Biomaterials
Ocular bioprinting
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing