AccScience Publishing / IJB / Volume 7 / Issue 4 / DOI: 10.18063/ijb.v7i4.420
Cite this article
39
Download
1343
Views
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
RESEARCH ARTICLE

Development of a Multi-Material 3D Printer for Functional Anatomic Models

Laszlo Jaksa1,2* Dieter Pahr2,3 Gernot Kronreif1 Andrea Lorenz1
Show Less
1 Austrian Center for Medical Innovation and Technology (ACMIT Gmbh), Viktor-Kaplan-Strasse 2/A, 2700 Wiener Neustadt, Austria
2 Technical University of Vienna, Institute of Lightweight Design and Structural Biomechanics, Object 8, Gumpendorfer Strasse 7, 1060 Vienna, Austria
3 Karl Landsteiner University of Health Sciences, Department of Anatomy and Biomechanics, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems an der Donau, Austria
© Invalid date by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Anatomic models are important in medical education and pre-operative planning as they help students or doctors prepare for real scenarios in a risk-free way. Several experimental anatomic models were made with additive manufacturing techniques to improve geometric, radiological, or mechanical realism. However, reproducing the mechanical behavior of soft tissues remains a challenge. To solve this problem, multi-material structuring of soft and hard materials was proposed in this study, and a three-dimensional (3D) printer was built to make such structuring possible. The printer relies on extrusion to deposit certain thermoplastic and silicone rubber materials. Various objects were successfully printed for testing the feasibility of geometric features such as thin walls, infill structuring, overhangs, and multi-material interfaces. Finally, a small medical image-based ribcage model was printed as a proof of concept for anatomic model printing. The features enabled by this printer offer a promising outlook on mimicking the mechanical properties of various soft tissues.

Keywords
Silicone 3D printing
Multi-material 3D printing
Anatomic models
Soft tissues
References

1. Ventola CL, 2014, Medical Applications for 3D Printing: Current and Projected Uses. P T, 39:704–11.

2. Rengier F, Mehndiratta A, von Tengg-Kobligk H, et al., 2010, 3D Printing Based on Imaging Data: Review of Medical Applications. Int J Comput Assist Radiol Surg, 5:335–41. https://doi.org/10.1007/s11548-010-0476-x

3. Wang K, Ho CC, Zhang C, et al., 2017, A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and Organ Applications. Engineering, 3:653–62. https://doi.org/10.1016/j.eng.2017.05.013

4. Pietrabissa A, Marconi S, Negrello E, et al., 2019, An Overview on 3D Printing for Abdominal Surgery. Surg Endosc, 34(1):1–13. https://doi.org/10.1007/s00464-019-07155-5

5. Preece D, Williams SB, Lam R, et al., 2013, Let’s Get Physical: Advantages of a Physical Model Over 3D Computer Models and Textbooks in Learning Imaging Anatomy. Anat Sci Educ., 6:216–24. https://doi.org/10.1002/ase.1345

6. Khot Z, Quinlan K, Norman GR, et al., 2013, The Relative Effectiveness of Computer-based and Traditional Resources for Education in Anatomy. Anat Sci Educ., 6:211–5. 

7. Sulaiman A, Boussel L, Taconnet F, et al., 2008, In vitro Non-rigid Life-size Model of Aortic Arch Aneurysm for Endovascular Prosthesis Assessment. Eur J Cardiothorac Surg, 33:53–7. https://doi.org/10.1016/j.ejcts.2007.10.016

8. Giesel FL, Hart AR, Hahn HK, et al., 2009, 3D Reconstructions of the Cerebral Ventricles and Volume Quantification in Children with Brain Malformations. Acad Radiol, 16:610–7. https://doi.org/10.1016/j.acra.2008.11.010

9. Golab A, Smektala T, Kaczmarek K, et al., 2017, Laparoscopic Partial Nephrectomy Supported by Training Involving Personalized Silicone Replica Poured in Three-Dimensional Printed Casting Mold. J Laparoendosc Adv Surg Tech A, 27:420–2. https://doi.org/10.1089/lap.2016.0596

10. Mavili ME, Canter HI, Sağlam-Aydinatay B, et al., 2007, Use of Three-Dimensional Medical Modeling Methods for Precise Planning of Orthognathic Surgery. J Craniofac Surg, 18:740–7. https://doi.org/10.1097/scs.0b013e318069014f

11. Poukens J, Haex J, Riediger D, 2003, The Use of Rapid Prototyping in the Preoperative Planning of Distraction Osteogenesis of the Cranio-maxillofacial Skeleton. Comput Aided Surg, 8:146–54. https://doi.org/10.3109/10929080309146049

12. Tack P, Victor J, Gemmel P, et al., 2016, 3D-Printing Techniques in a Medical Setting: A Systematic Literature Review. Biomed Eng Online, 15:115. https://doi.org/10.1186/s12938-016-0236-4

13. Yan Q, Dong H, Su J, et al., 2018, A Review of 3D Printing Technology for Medical Applications. Engineering, 4:729–42.

14. Qian Z, Wang K, Liu S, et al., 2017, Quantitative Prediction of Paravalvular Leak in Transcatheter Aortic Valve Replacement Based on Tissue-Mimicking 3D Printing. JACC Cardiovasc Imaging, 10:719–31. https://doi.org/10.1016/j.jcmg.2017.04.005

15. Ratinam R, Quayle M, Crock J, et al., 2019, Challenges in Creating Dissectible Anatomical 3D Prints for Surgical Teaching. J Anat, 234:419–37. https://doi.org/10.1111/joa.12934

16. Wang K, Wu C, Qian Z, et al., 2016, Dual-material 3D Printed Metamaterials with Tunable Mechanical Properties for Patient-specific Tissue-mimicking Phantoms. Addit Manuf, 12:31–7. https://doi.org/10.1016/j.addma.2016.06.006

17. Wang K, Zhao Y, Chang YH, et al., 2016, Controlling the Mechanical Behavior of Dual-material 3D Printed Meta materials for Patient-specific Tissue-mimicking Phantoms. Mater Des, 90:704–12. https://doi.org/10.1016/j.matdes.2015.11.022

18. Goh GL, Zhang H, Chong TH, et al., 2021, 3D Printing of Multilayered and Multimaterial Electronics: A Review. Adv Electron Mater, 2021:2100445. https://doi.org/10.1002/aelm.202100445

19. Yap YL, Sing SL, Yeong WY, 2020, A Review of 3D Printing Processes and Materials for Soft Robotics. Rapid Prototyp J, 26:1345–61. https://doi.org/10.1108/rpj-11-2019-0302

20. Qiu K, Haghiashtiani G, McAlpine MC, 2018, 3D Printed Organ Models for Surgical Applications. Annu Rev Anal Chem, 11:287–306. https://doi.org/10.1146/annurev-anchem-061417-125935

21. Ngo TD, Kashani A, Imbalzano G, et al., 2018, Additive Manufacturing (3D Printing): A Review of Materials, Methods, Applications and Challenges. Compos B Eng, 143:172–96. https://doi.org/10.1016/j.compositesb.2018.02.012

22. Pugliese L, Marconi S, Negrello E, et al., 2018, The Clinical Use of 3D Printing in Surgery. Updates Surg, 70:381–8. https://doi.org/10.1007/s13304-018-0586-5

23. Dorweiler B, Baqué PE, Chaban R, et al., 2021, Quality Control in 3D Printing: Accuracy Analysis of 3D-Printed Models of Patient-Specific Anatomy. Materials, 14:1021. https://doi.org/10.3390/ma14041021

24. Stratasys Ltd. Available from: https://stratasys.com/medical/advanced-medical-models. [Last accessed on 2021 Jan 10].

25. Mirzaali MJ, Nava AH, Gunashekar D, et al., 2020, Mechanics of Bioinspired Functionally Graded Soft-hard Composites Made by Multi-material 3D Printing. Composit Struct, 237:111867. https://doi.org/10.1016/j.compstruct.2020.111867

26. Ionita CN, Mokin M, Varble N, et al., 2014, Challenges and Limitations of Patient-specific Vascular Phantom Fabrication Using 3D Polyjet Printing. Proc SPIE Int Soc Opt Eng, 9038: 90380M. https://doi.org/10.1117/12.2042266

27. Reiter M, Major Z, 2011, A Combined Experimental and Simulation Approach for Modelling the Mechanical Behaviour of Heterogeneous Materials Using Rapid Prototyped Microcells. Virtual Phys Prototyp, 6:111–20. https://doi.org/10.1080/17452759.2011.586949

28. Hiller J, Lipson H, 2010, Tunable Digital Material Properties for 3D Voxel Printers. Rapid Prototyp J, 16:241–7. https://doi.org/10.1108/13552541011049252 

29. Patent, 2019, Additive Manufacturing of Rubber-like Materials. Patent US2019224914A1.

30. Slesarenko VY, 2017, Towards Mechanical Characterization of Soft Digital Materials for Multimaterial 3D-Printing. Int J Eng Sci, 123:62–72. https://doi.org/10.1016/j.ijengsci.2017.11.011

31. Goh GL, Agarwala S, Yong WI, 2016, 3D Printing of Microfludic Sensor for Soft Robots: A Preliminary Study in Design and Fabrication. In: Proceedings of the 2nd International Conference on Progress in Additive Manufacturing (Pro-AM 2016). p177–81.

32. Truby RL, Lewis JA, 2016, Printing Soft Matter in Three Dimensions. Nature, 540:371–8. https://doi.org/10.1038/nature21003

33. Yeo J, Koh J, Wang F, et al., 2020, 3D Printing Silicone Materials and Devices. In: Silicon Containing Hybrid Copolymers. Germany: Wiley-VCH Verlag GmbH & Co. KGaA; 2020, p. 239–63. https://doi.org/10.1002/9783527823499.ch9

34. Zhao Y, Yao R, Ouyang L, et al., 2014, Three-dimensional Printing of Hela Cells for Cervical Tumor Model In Vitro. Biofabrication, 6:035001. https://doi.org/10.1088/1758-5082/6/3/035001

35. Lee JM, Sing SL, Yeong WY, 2020, Bioprinting of Multimaterials with Computer-aided Design/Computer-aided Manufacturing. Int J Bioprint, 6:245. https://doi.org/10.18063/ijb.v6i1.245

36. Liu W, Zhang YS, Heinrich MA, et al., 2016, Rapid Continuous Multimaterial Extrusion Bioprinting. Adv Mater, 29:1604630.

37. Hardin JO, Ober TJ, Valentine AD, et al., 2015, Microfluidic Printheads for Multimaterial 3D Printing of Viscoelastic Inks. Adv Mater, 27:3279–84. https://doi.org/10.1002/adma.201570145

38. Skylar-Scott MA, Mueller J, Visser CW, et al., 2019, Voxelated Soft Material Via Multimaterial Multinozzle 3D Printing. Nature, 575:330–4. https://doi.org/10.1038/s41586-019-1736-8

39. Wacker Chemie AG, 2021, Avaialble from: https://www.aceo3d.com/3d-printing [Last accessed on 2021 Jan 10].

40. GermanRepRap GmbH, 2021, Avaialble from: https://www.germanreprap.com/material-de/SILASTIC-3D-3335.aspx [Last accessed on 2021 Jan 10].

41. Fripp Design Ltd., 2021, Avaialble from: https://www.picsima.com [Last accessed on 2021 Jan 10].

42. Deltatower GmbH, 2021, Avaialble from: https://www.deltatower.ch/en/home-2 [Last accessed on 2021 Jan 10]. 

43. Spectroplast AG, 2021, Avaialble from: https://www.spectroplast.com [Last accessed on 2021 Jan 10].

44. Coulter F, 2021, Avaialble from: http://www.fergalcoulter.eu [Last accessed on 2021 Jan 10].

45. Coulter F, Schaffner M, Faber J, et al., 2019, Bioinspired Heart Valve Prosthesis Made by Silicone Additive Manufacturing. Matter, 1:266–79. https://doi.org/10.1016/j.matt.2019.05.013

46. Luis E, Pan HM, Sing SL, et al., 2019, Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants. 3D Print Addit Manufact, 6:319–32. https://doi.org/10.1089/3dp.2018.0226

47. Luis E, Pan HM, Sing SL, et al., 2020, 3D Direct Printing of Silicone Meniscus Implant Using a Novel Heat-Cured Extrusion-Based Printer. Polymers, 12:1031. https://doi.org/10.3390/polym12051031

48. Patent, 2017, 3D-printing Device and Process for Producting an Object with Use of a 3D-Printing Device, Patent WO2017108208A1.

49. Patent, 2017, 3D Printing Method Utilizing Heat-curable Silicone Composition, Patent WO2017040874A1.

50. Studart AR, 2016, Additive Manufacturing of Biologically inspired Materials. Chem Soc Rev, 45:359–76. https://doi.org/10.1039/c5cs00836k

51. Bakarich SE, Gorkin R, Panhuis M, et al., 2014, Three-Dimensional Printing Fiber Reinforced Hydrogel Composites. ACS Appl Mater Interfaces, 6:15998–16006. https://doi.org/10.1021/am503878d

52. Viscotec GmbH, 2021, Avaialble from: https://www.viscotec. de/produkte/3d-druckkoepfe [Last accessed on 2021 Jan 10].

53. White JS, Akens T, 2021, Avaialble from: https://railcore.org [Last accessed on 2021 Jan 10].

54. Duet3D Advanced 3D Printing Electronics, 2021, Available from: https://www.duet3d.com/DuetWifi [Last accessed on 2021 Jan 10].

55. Prusa Research, 2021, Avaialble from: https://www.prusa3d. com/prusaslicer [Last accessed on 2021 Jan 10].

Share
Back to top
International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing