AccScience Publishing / IJB / Volume 4 / Issue 2 / DOI: 10.18063/ijb.v4i2.140
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REVIEW

Bioprinting of artificial blood vessels

Hooi Yee Ng1,2 Kai-Xing Alvin Lee1,2 Che-Nan Kuo3,4 Yu-Fang Shen3,4*
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1 3D Printing Medical Research Center, China Medical University Hospital, China Medical University, Taichung City, Taiwan
2 School of Medicine, College of Medicine, China Medical University, Taichung City, Taiwan
3 3D Printing Medical Research Institute, Asia University, Taichung City, Taiwan
4 Department of Bioinformatics and Medical Engineering, Asia University, Taichung City, Taiwan
© Invalid date by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Vascular networks have an important role to play in transporting nutrients, oxygen, metabolic wastes and maintenance of homeostasis. Bioprinting is a promising technology as it is able to fabricate complex, specific multi-cellular constructs with precision. In addition, current technology allows precise depositions of individual cells, growth factors and biochemical signals to enhance vascular growth. Fabrication of vascularized constructs has remained as a main challenge till date but it is deemed as an important stepping stone to bring organ engineering to a higher level. However, with the ever advancing bioprinting technology and knowledge of biomaterials, it is expected that bioprinting can be a viable solution for this problem. This article presents an overview of the biofabrication of vascular and vascularized constructs, the different techniques used in vascular engineering such as extrusion-based, droplet-based and laser-based bioprinting techniques, and the future prospects of bioprinting of artificial blood vessels. 

Keywords
3D bioprinting
vascularized constructs
vascular tissue engineering
extrusion-based bioprinting
droplet-based bioprinting
laser-based bioprinting
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing