A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering

¹ State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

² Jiangxi University of Science and Technology, Ganzhou 341000, China

³ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, the Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Cancer Research Institute, Xiangya Hospital, Central South University, Changsha 410078, China

⁴ Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410008, China

IJB 2018, 4(2), 133 https://doi.org/10.18063/ijb.v4i1.133

© Invalid date by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment. In this work, a novel combined process of additive manufacturing (AM) and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid) (GO/PLLA) scaffolds with multiscale porous structure. Specially, AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns. And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface. The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores. Moreover, the scaffolds exhibited surprising bioactivity after chemical etching, which was ascribed to the formed polar groups on scaffolds surfaces. Furthermore, GO improved the mechanical strength of the scaffolds.

Keywords

multi-scale pores

scaffolds

additive manufacturing

chemical etching

PLLA

References

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