AccScience Publishing / EJMO / Online First / DOI: 10.36922/EJMO025220226
Cite this article
10
Download
50
Views
Related Info Links
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
REVIEW ARTICLE

Advances in image processing and pattern recognition in cancer detection, prediction, diagnosis, and prognosis

Ashok Kumar Sah1* Ranjay Kumar Choudhary1 Rabab H. Elshaikh1 Shagun Agarwal2 Manar G. Shalabi3 Rajesh Prasad Jayaswal4 Nurova Zarnigor Hikmatovna5 Navjyot Trivedi6 Khoula Salim Ali Buwaiqi7 Said Al Ghenaimi8* Pranav Kumar Prabhakar9 Hatem Mohamed10
Show Less
1 Department of Medical Laboratory Sciences, College of Applied & Health Sciences, A’ Sharqiyah University, Ibra, North Al Sharqiyah Governorate, Oman
2 School of Allied Health Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India
3 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Al-Jawf Region, Saudi Arabia
4 Department of Medical Laboratory Technology, University Institute of Allied Health Sciences, Chandigarh University, Mohali, Punjab, India
5 Department of Folk Medicine, Faculty of Traditional Medicine, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Bukhara Region, Republic of Uzbekistan
6 Department of Physiotherapy, University Institute of Allied Health Sciences, Chandigarh University, Gharuan, Punjab, India
7 Research, Innovation and Technology Transfer Center, A’ Sharqiyah University, Ibra, North Al Sharqiyah Governorate, Oman
8 College of Applied and Health Sciences, A’ Sharqiyah University, Ibra, North Al Sharqiyah Governorate, Oman
9 Department of Biotechnology, School of Engineering and Technology, Nagaland University Meriema Campus, Kohima, Nagaland, India
10 Department of Counseling and Mental Health, College of Education and Arts, Lusail University, Lusail, Al Daayen, Doha, Qatar
Received: 29 May 2025 | Revised: 2 November 2025 | Accepted: 14 November 2025 | Published online: 1 July 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Cancer remains a global health issue, with early detection, correct diagnosis, and exact prognosis playing critical roles in improving patient outcomes. Recent developments in image processing and pattern recognition have significantly enhanced cancer detection, prediction, diagnosis, and prognosis, bridging the gap between conventional radiological methods and state-of-the-art artificial intelligence (AI)-based analytics. This review provides an in-depth introduction to the concepts, methods, and practical applications of image processing and pattern recognition in oncology. Image preprocessing algorithms, tumor segmentation algorithms, feature extraction, and pattern recognition methods based on AI, such as machine learning and deep learning models (e.g., convolutional neural networks, recurrent neural networks, and transformers), are all significant areas. We reviewed cancer prediction using radiomics, radiogenomics, AI-based histopathological diagnosis, and multimodal data fusion from imaging, genomics, and clinical history for personalized prognosis. The impact of explainable AI, 3D/4D imaging, nanotechnology-facilitated imaging, and cloud-based AI solutions is also discussed, including its impact on precision oncology and remote diagnosis. Even with these developments, significant clinical use limitations remain, including limited annotated datasets, poor interpretability, ethical considerations, and regulatory issues. This review focuses on emerging trends, including federated learning, quantum computing, and real-time AI applications, that could revolutionize cancer imaging and management. Image processing and pattern recognition, if integrated with interdisciplinary research, have the potential to develop more precise, equitable, and egalitarian cancer care in the future.

Keywords
Cancer imaging
Pattern recognition
Tumor classification
Artificial intelligence in cancer diagnosis
Multimodal data integration
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
References
  1. Rumgay H, Nethan ST, Shah R, et al. Global burden of oral cancer in 2022 attributable to smokeless tobacco and areca nut consumption: a population attributable fraction analysis. Lancet Oncol. 2024;25:1413–1423. doi: 10.1016/S1470-2045(24)00458-3

 

  1. Zhang B, Shi H, Wang H. Machine Learning and AI in Cancer Prognosis, Prediction, and Treatment Selection: A Critical Approach. J Multidiscip Healthc. 2023;16:1779– 1791. doi: 10.2147/JMDH.S410301

 

  1. Bi WL, Hosny A, Schabath MB, et al. Artificial intelligence in cancer imaging: Clinical challenges and applications. CA Cancer J Clin. 2019;69:127–157. doi: 10.3322/caac.21552

 

  1. Bera K, Braman N, Gupta A, Velcheti V, Madabhushi A. Predicting cancer outcomes with radiomics and artificial intelligence in radiology. Nat Rev Clin Oncol. 2022;19:132– 146. doi: 10.1038/s41571-021-00560-7

 

  1. Abut S, Okut H, Kallail KJ. Paradigm shift from Artificial Neural Networks (ANNs) to deep Convolutional Neural Networks (DCNNs) in the field of medical image processing. Expert Syst Appl. 2024;244:122983. doi: 10.1016/j.eswa.2023.122983

 

  1. Cheng T, Zhan X. Pattern recognition for predictive, preventive, and personalized medicine in cancer. EPMA J. 2017;8:51–60. doi: 10.1007/s13167-017-0083-9

 

  1. Obuchowicz R, Lasek JA, Wodziński M, Piórkowski Strzelecki M, Nurzynska K. Artificial Intelligence- Empowered Radiology-Current Status and Critical Review. Diagnostics. 2025;15(3):282. doi: 10.3390/diagnostics15030282

 

  1. Frangioni J V. New technologies for human cancer imaging. J Clin Oncol. 2008;26(24):4012–4021. doi: 10.1200/JCO.2007.14.3065

 

  1. Passaro A, Al Bakir M, Hamilton EG, et al. Cancer biomarkers: Emerging trends and clinical implications for personalized treatment. Cell. 2024;187(7):1617–1635. doi: 10.1016/j.cell.2024.02.041

 

  1. Dankwa-Mullan I, Ndoh K, Akogo D, Rocha HAL, Juaçaba SF. Artificial Intelligence and Cancer Health Equity: Bridging the Divide or Widening the Gap. Curr Oncol Rep. 2025;27(2):95-111. doi: 10.1007/s11912-024-01627-1

 

  1. Marra A, Morganti S, Pareja F, et al. Artificial intelligence entering the pathology arena in oncology: current applications and future perspectives. Ann Oncol. 2025;36(7):712-725. doi: 10.1016/j.annonc.2025.03.006

 

  1. Mohammadzadeh Z, Safdari R, Ghazisaeidi M, Davoodi S, Azadmanjir Z. Advances in Optimal Detection of Cancer by Image Processing; Experience with Lung and Breast Cancers. Asian Pac J Cancer Prev. 2015;16(14):5613–5618. doi: 10.7314/apjcp.2015.16.14.5613

 

  1. Liao C-W, Hsieh T-C, Lai Y-C, et al. Artificial Intelligence of Object Detection in Skeletal Scintigraphy for Automatic Detection and Annotation of Bone Metastases. Diagnostics. 2023;13(4):685. doi: 10.3390/diagnostics13040685

 

  1. Elemento O, Leslie C, Lundin J, Tourassi G. Artificial intelligence in cancer research, diagnosis and therapy. Nat Rev Cancer. 2021;21(12):747–752. doi: 10.1038/s41568-021-00399-1

 

  1. Wang H, Hong Y, Zhang Z, Cheng K, Chen B, Zhang R. Study on postoperative survival prediction model for non-small cell lung cancer: application of radiomics technology workflow based on multi-organ imaging features and various machine learning algorithms. Front Med. 2025;12:1517765. doi: 10.3389/fmed.2025.1517765

 

  1. Wang T, She Y, Yang Y, et al. Radiomics for Survival Risk Stratification of Clinical and Pathologic Stage IA Pure-Solid Non-Small Cell Lung Cancer. Radiology. 2022;302(2):425– 434. doi: 10.1148/radiol.2021210109

 

  1. Mu W, Jiang L, Zhang J, et al. Non-invasive decision support for NSCLC treatment using PET/CT radiomics. Nat Commun. 2020;11:5228. doi: 10.1038/s41467-020-19116-x

 

  1. Zhang R, Zhu H, Chen M, et al. A dual-radiomics model for overall survival prediction in early-stage NSCLC patient using pre-treatment CT images. Front Oncol. 2024;14:1419621. doi: 10.3389/fonc.2024.1419621

 

  1. Shen S, Li C, Fan Y, et al. Development and validation of a multi-modality fusion deep learning model for differentiating glioblastoma from solitary brain metastases. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024;49:58–67. doi: 10.11817/j.issn.1672-7347.2024.230248

 

  1. Salmanpour MR, Rezaeijo SM, Hosseinzadeh M, Rahmim A. Deep versus Handcrafted Tensor Radiomics Features: Prediction of Survival in Head and Neck Cancer Using Machine Learning and Fusion Techniques. Diagnostics. 2023;13(10):1696. doi: 10.3390/diagnostics13101696

 

  1. Lee JY, Lee K-S, Seo BK, et al. Radiomic machine learning for predicting prognostic biomarkers and molecular subtypes of breast cancer using tumor heterogeneity and angiogenesis properties on MRI. Eur Radiol. 2022;32:650–660. doi: 10.1007/s00330-021-08146-8

 

  1. Zandie F, Salehi M, Maziar A, Bayatiani MR, Paydar R. Radiomics based Machine Learning Models for Classification of Prostate Cancer Grade Groups from Multi Parametric MRI Images. J Med Signals Sens. 2024;14(12):33. doi: 10.4103/jmss.jmss_47_23

 

  1. Li W, Yu S, Yang R, et al. Machine Learning Model of ResNet50-Ensemble Voting for Malignant-Benign Small Pulmonary Nodule Classification on Computed Tomography Images. Cancers. 2023;15(22):5417. doi: 10.3390/cancers15225417

 

  1. Ramamoorthy P, Ramakantha Reddy BR, Askar SS, Abouhawwash M. Histopathology-based breast cancer prediction using deep learning methods for healthcare applications. Front Oncol. 2024;14:1300997. doi: 10.3389/fonc.2024.1300997

 

  1. Jiang B, Bao L, He S, Chen X, Jin Z, Ye Y. Deep learning applications in breast cancer histopathological imaging: diagnosis, treatment, and prognosis. Breast Cancer Res. 2024;26:137. doi: 10.1186/s13058-024-01895-6

 

  1. Liz-López H, de Sojo-Hernández ÁA, D’Antonio-Maceiras S, Díaz-Martínez MA, Camacho D. Deep Learning Innovations in the Detection of Lung Cancer: Advances, Trends, and Open Challenges. Cognit Comput. 2025;17(2):67. doi: 10.1007/s12559-025-10408-2

 

  1. Shahzad T, Mazhar T, Saqib SM, Ouahada K. Transformer-inspired training principles based breast cancer prediction: combining EfficientNetB0 and ResNet50. Sci Rep. 2025;15:13501. doi: 10.1038/s41598-025-98523-w

 

  1. Alleman K, Knecht E, Huang J, Zhang L, Lam S, DeCuypere M. Multimodal Deep Learning-Based Prognostication in Glioma Patients: A Systematic Review. Cancers. 2023;15(2):545. doi: 10.3390/cancers15020545

 

  1. Orlhac F, Frouin F, Nioche C, Ayache N, Buvat I. Validation of A Method to Compensate Multicenter Effects Affecting CT Radiomics. Radiology. 2019;291:53–59. doi: 10.1148/radiol.2019182023

 

  1. Sharma M, Dogra A, Goyal B, Gupta A, Saikia MJ. Detail-preserving denoising of CT and MRI images via adaptive clustering and non-local means algorithm. Sci Rep. 2025;15:23859. doi: 10.1038/s41598-025-08034-x

 

  1. Alamri Y, Magner K, Wilkinson TJ. Would you do it again? A qualitative study of student and supervisor perceptions of an intercalated MBChB/PhD programme. BMC Med Educ. 2019;19:471. doi: 10.1186/s12909-019-1909-z

 

  1. Vidrine DJ, Hoekstra-Weebers JEHM, Hoekstra HJ, Tuinman MA, Marani S, Gritz ER. The effects of testicular cancer treatment on health-related quality of life. Urology. 2010;75(3):636–641. doi: 10.1016/j.urology.2009.09.053

 

  1. Isensee F, Jaeger PF, Kohl SAA, Petersen J, Maier-Hein KH. nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat Methods. 2021;18(2):203–211. doi: 10.1038/s41592-020-01008-z

 

  1. Ghaffari M, Sowmya A, Oliver R. Automated Brain Tumor Segmentation Using Multimodal Brain Scans: A Survey Based on Models Submitted to the BraTS 2012-2018 Challenges. IEEE Rev Biomed Eng. 2020;13:156–168. doi: 10.1109/RBME.2019.2946868

 

  1. Liu Y, Mu F, Shi Y, Cheng J, Li C, Chen X. Brain tumor segmentation in multimodal MRI via pixel-level and feature-level image fusion. Front Neurosci. 2022;16:1000587. doi: 10.3389/fnins.2022.1000587

 

  1. Gould L, Parmar C. A Commentary on “Closure of mesenteric defects is associated with a higher incidence of small bowel obstruction due to adhesions after laparoscopic antecolic Roux-en-y gastric bypass: a retrospective cohort study” (Int J Surg 2019 Oct. Epub ahead of print). Int J Surg. 2019;72:55–56. doi: 10.1016/j.ijsu.2019.10.011

 

  1. Cai Z, Xu Z, Chen Y, et al. Multiparametric MRI subregion radiomics for preoperative assessment of high-risk subregions in microsatellite instability of rectal cancer patients: a multicenter study. Int J Surg. 2024;110(7):4310– 4319. doi: 10.1097/JS9.0000000000001335

 

  1. Cao Y, Zhang W, Wang X, et al. Multiparameter MRI-based radiomics analysis for preoperative prediction of type II endometrial cancer. Heliyon. 2024;10(12):e32940. doi: 10.1016/j.heliyon.2024.e32940

 

  1. Mazzaschi G, Milanese G, Pagano P, et al. Dataset on the identification of a prognostic radio-immune signature in surgically resected Non Small Cell Lung Cancer. Data Brief. 2020;31:105781. doi: 10.1016/j.dib.2020.105781

 

  1. Demircioglu A, Grueneisen J, Ingenwerth M, et al. A rapid volume of interest-based approach of radiomics analysis of breast MRI for tumor decoding and phenotyping of breast cancer. PLoS ONE. 2020;15(6):e0234871. doi: 10.1371/journal.pone.0234871

 

  1. Zou J, Gao B, Song Y, Qin J. A review of deep learning-based deformable medical image registration. Front Oncol. 2022;12:1047215. doi: 10.3389/fonc.2022.1047215

 

  1. Derks SHAE, van der Veldt AAM, Smits M. Brain metastases: the role of clinical imaging. Br J Radiol. 2022;95(1130):20210944. doi: 10.1259/bjr.20210944

 

  1. McWilliams A, Tammemagi MC, Mayo JRK, et al. Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med. 2013;369(10):910–919. doi: 10.1056/NEJMoa1214726

 

  1. Theodoropoulos AS, Gkiozos I, Kontopyrgias G, et al. Modern radiopharmaceuticals for lung cancer imaging with positron emission tomography/computed tomography scan: A systematic review. SAGE Open Med. 2020;8:2050312120961594. doi: 10.1177/2050312120961594

 

  1. Zhou M, Scott J, Chaudhury B, et al. Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches. AJNR Am J Neuroradiol. 2018;39(2):208–216. doi: 10.3174/ajnr.A5391

 

  1. Calabrese E, Rudie JD, Rauschecker AM, et al. Combining radiomics and deep convolutional neural network features from preoperative MRI for predicting clinically relevant genetic biomarkers in glioblastoma. Neurooncol Adv. 2022;4:vdac060. doi: 10.1093/noajnl/vdac060

 

  1. Kong C, Yan D, Liu K, Yin Y, Ma C. Multiple deep learning models based on MRI images in discriminating glioblastoma from solitary brain metastases: a multicentre study. BMC Med Imaging. 2025;25(1):171. doi: 10.1186/s12880-025-01703-3

 

  1. Aswathy MA, Jagannath M. An SVM approach towards breast cancer classification from H&E-stained histopathology images based on integrated features. Med Biol Eng Comput. 2021;59(9):1773–1783. doi: 10.1007/s11517-021-02403-0

 

  1. Belladelli F, De Cobelli F, Piccolo C, et al. A machine learning-based analysis for the definition of an optimal renal biopsy for kidney cancer. Urol Oncol. 2025;43(4):270.e1-270. e8. doi: 10.1016/j.urolonc.2024.10.020

 

  1. Pham TD. Integrating support vector machines and deep learning features for oral cancer histopathology analysis. Biol Methods Protoc. 2025;10:bpaf034. doi: 10.1093/biomethods/bpaf034

 

  1. Marentakis P, Karaiskos P, Kouloulias V, et al. Lung cancer histology classification from CT images based on radiomics and deep learning models. Med Biol Eng Comput. 2021;59:215–226. doi: 10.1007/s11517-020-02302-w

 

  1. Ishaq A, Ullah FUM, Hamandawana P, Cho D-J, Chung T-S. Improved EfficientNet Architecture for Multi-Grade Brain Tumor Detection. Electronics. 2025;14(4):710. doi: 10.3390/electronics14040710

 

  1. Kumar R, Srivastava R, Srivastava S. Detection and Classification of Cancer from Microscopic Biopsy Images Using Clinically Significant and Biologically Interpretable Features. J Med Eng. 2015;2015:457906. doi: 10.1155/2015/457906

 

  1. Kim HE, Cosa-Linan A, Santhanam N, Jannesari M, Maros ME, Ganslandt T. Transfer learning for medical image classification: a literature review. BMC Med Imaging. 2022;22:69. doi: 10.1186/s12880-022-00793-7

 

  1. Yang F, Chen W, Wei H, et al. Machine Learning for Histologic Subtype Classification of Non-Small Cell Lung Cancer: A Retrospective Multicenter Radiomics Study. Front Oncol. 2021;10. doi: 10.3389/fonc.2020.608598

 

  1. Bairagi VK, Gumaste PP, Rajput SH, Chethan K S. Automatic brain tumor detection using CNN transfer learning approach. Med Biol Eng Comput. 2023;61(7):1821–1836. doi: 10.1007/s11517-023-02820-3

 

  1. Nahiduzzaman Md, Abdulrazak LF, Kibria HB, et al. A hybrid explainable model based on advanced machine learning and deep learning models for classifying brain tumors using MRI images. Sci Rep. 2025;15:1649. doi: 10.1038/s41598-025-85874-7

 

  1. Munshi RM. Novel ensemble learning approach with SVM-imputed ADASYN features for enhanced cervical cancer prediction. PLoS ONE. 2024;19:e0296107. doi: 10.1371/journal.pone.0296107

 

  1. Shekarian T, Valsesia-Wittmann S, Brody J, et al. Pattern recognition receptors: immune targets to enhance cancer immunotherapy. Ann Oncol. 2017;28(8):1756–1766. doi: 10.1093/annonc/mdx179

 

  1. Huang S, Cai N, Pacheco PP, Narrandes S, Wang Y, Xu W. Applications of Support Vector Machine (SVM) Learning in Cancer Genomics. Cancer Genom Proteom. 2018;15:41–51. doi: 10.21873/cgp.20063

 

  1. Jiang X, Hu Z, Wang S, Zhang Y. Deep Learning for Medical Image-Based Cancer Diagnosis. Cancers. 2023;15(14):3608. doi: 10.3390/cancers15143608

 

  1. Zanjani FG, Panteli A, Zinger S, et al. Cancer Detection in Mass Spectrometry Imaging Data by Recurrent Neural Networks. 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). IEEE; 2019:p.674–678. doi: 10.1109/ISBI.2019.8759571

 

  1. Ayana G, Dese K, Choe S-W. Transfer Learning in Breast Cancer Diagnoses via Ultrasound Imaging. Cancers. 2021;13(4):738. doi: 10.3390/cancers13040738

 

  1. Chen W, Tan X, Zhang J, Du G, Fu Q, Jiang H. A robust approach for multi-type classification of brain tumor using deep feature fusion. Front Neurosci. 2024;18:1288274. doi: 10.3389/fnins.2024.1288274

 

  1. Mohammed M, Mwambi H, Mboya IB, Elbashir MK, Omolo B. A stacking ensemble deep learning approach to cancer type classification based on TCGA data. Sci Rep. 2021;11:15626. doi: 10.1038/s41598-021-95128-x

 

  1. Kolla L, Parikh RB. Uses and limitations of artificial intelligence for oncology. Cancer. 2024;130(12):2101–2107. doi: 10.1002/cncr.35307

 

  1. Silva HEC da, Santos GNM, Leite AF, et al. The use of artificial intelligence tools in cancer detection compared to the traditional diagnostic imaging methods: An overview of the systematic reviews. PLoS ONE. 2023;18(10):e0292063. doi: 10.1371/journal.pone.0292063

 

  1. Hosni M, Abnane I, Idri A, Carrillo de Gea JM, Fernández Alemán JL. Reviewing ensemble classification methods in breast cancer. Comput Methods Programs Biomed. 2019;177:89–112. doi: 10.1016/j.cmpb.2019.05.019

 

  1. Forouzannezhad P, Maes D, Hippe DS, et al. Multitask Learning Radiomics on Longitudinal Imaging to Predict Survival Outcomes following Risk-Adaptive Chemoradiation for Non-Small Cell Lung Cancer. Cancers. 2022;14(5):1228. doi: 10.3390/cancers14051228

 

  1. Lococo F, Ghaly G, Chiappetta M, et al. Implementation of Artificial Intelligence in Personalized Prognostic Assessment of Lung Cancer: A Narrative Review. Cancers. 2024;16(10):1832. doi: 10.3390/cancers16101832

 

  1. Gao F, Ding J, Gai B, et al. Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer. Adv Sci. 2025;12(17):e2407060. doi: 10.1002/advs.202407060

 

  1. Ding H, Dong Z. A novel multimodal framework integrating pathomics, deep learning, and machine learning for breast cancer histological grades classification. Diagn Pathol. 2026;21:40. doi: 10.1186/s13000-026-01769-9

 

  1. Hormuth DA, Jarrett AM, Lima EABF, McKenna MT, Fuentes DT, Yankeelov TE. Mechanism-Based Modeling of Tumor Growth and Treatment Response Constrained by Multiparametric Imaging Data. JCO Clin Cancer Inform. 2019;3:1–10. doi: 10.1200/CCI.18.00055

 

  1. Kazerouni AS, Gadde M, Gardner A, et al. Integrating Quantitative Assays with Biologically Based Mathematical Modeling for Predictive Oncology. iScience. 2020;23(12):101807. doi: 10.1016/j.isci.2020.101807

 

  1. Yankeelov TE, Atuegwu NC, Deane NG, Gore JC. Modeling tumor growth and treatment response based on quantitative imaging data. Integr Biol. 2010;2(7-8):338–345. doi: 10.1039/b921497f

 

  1. Lam S, Bai C, Baldwin DR, et al. Current and Future Perspectives on Computed Tomography Screening for Lung Cancer: A Roadmap From 2023 to 2027 From the International Association for the Study of Lung Cancer. J Thorac Oncol. 2024;19:36–51. doi: 10.1016/j.jtho.2023.07.019

 

  1. Waterhouse DJ, Fitzpatrick CRM, Pogue BW, O’Connor JPB, Bohndiek SE. A roadmap for the clinical implementation of optical-imaging biomarkers. Nat Biomed Eng. 2019;3(5):339–353. doi: 10.1038/s41551-019-0392-5

 

  1. O’Connor JPB, Aboagye EO, Adams JE, et al. Imaging biomarker roadmap for cancer studies. Nat Rev Clin Oncol. 2017;14(3):169–186. doi: 10.1038/nrclinonc.2016.162

 

  1. Yang H, Wang J, Wang W, et al. MMsurv: a multimodal multi-instance multi-cancer survival prediction model integrating pathological images, clinical information, and sequencing data. Brief Bioinform. 2025;26(3). doi: 10.1093/bib/bbaf209

 

  1. Luo H, Huang J, Ju H, Zhou T, Ding W. Multimodal multi-instance evidence fusion neural networks for cancer survival prediction. Sci Rep. 2025;15:10470. doi: 10.1038/s41598-025-93770-3

 

  1. Feng X, Song G, Zhang Y. et al. Deep learning-based multimodal pathogenomics integration for precision cancer prognosis. J Transl Med. 2026;24:179. doi: 10.1186/s12967-026-07682-5

 

  1. Zhao T, Ren Y, Lu H, Kong Y. Decision level scheme for fusing multiomics and histology slide images using deep neural network for tumor prognosis prediction. Sci Rep. 2025;15:25479. doi: 10.1038/s41598-025-09869-0

 

  1. Hu Y, Li X, Yi Y, Huang Y, Wang G, Wang D. Deep learning-driven survival prediction in pan-cancer studies by integrating multimodal histology-genomic data. Brief Bioinform. 2025;26(2). doi: 10.1093/bib/bbaf121

 

  1. Yu C, Helwig EJ. The role of AI technology in prediction, diagnosis and treatment of colorectal cancer. Artif Intell Rev. 2022;55:323–343. doi: 10.1007/s10462-021-10034-y

 

  1. Gillies RJ, Schabath MB. Radiomics Improves Cancer Screening and Early Detection. Cancer Epidemiol Biomark Prev. 2020;29(12):2556–2567. doi: 10.1158/1055-9965.EPI-20-0075

 

  1. Sah AK, Elshaikh RH, Shalabi MG, et al. Role of Artificial Intelligence and Personalized Medicine in Enhancing HIV Management and Treatment Outcomes. Life. 2025;15(5):745. doi: 10.3390/life15050745

 

  1. Zeng A, Houssami N, Noguchi N, Nickel B, Marinovich ML. Frequency and characteristics of errors by artificial intelligence (AI) in reading screening mammography: a systematic review. Breast Cancer Res Treat. 2024;207:1–13. doi: 10.1007/s10549-024-07353-3

 

  1. Zhan Y, Hao Y, Wang X, Guo D. Advances of artificial intelligence in clinical application and scientific research of neuro-oncology: Current knowledge and future perspectives. Crit Rev Oncol Hematol. 2025;209:104682. doi: 10.1016/j.critrevonc.2025.104682

 

  1. Harrison H, Thompson RE, Lin Z, et al. Risk Prediction Models for Kidney Cancer: A Systematic Review. Eur Urol Focus. 2021;7(6):1380–1390. doi: 10.1016/j.euf.2020.06.024

 

  1. Cellina M, Cacioppa LM, Cè M, et al. Artificial Intelligence in Lung Cancer Screening: The Future Is Now. Cancers. 2023;15(17):4344. doi: 10.3390/cancers15174344

 

  1. Chen H, Lan X, Yu T, et al. Development and validation of a radiogenomics model to predict axillary lymph node metastasis in breast cancer integrating MRI with transcriptome data: A multicohort study. Front. Oncol. 2022;12:1076267. doi: 10.3389/fonc.2022.1076267

 

  1. Jia LL, Zheng QY, Tian JH, et al. Artificial intelligence with magnetic resonance imaging for prediction of pathological complete response to neoadjuvant chemoradiotherapy in rectal cancer: A systematic review and meta-analysis. Front. Oncol. 2022;12:1026216. doi: 10.3389/fonc.2022.1026216

 

  1. Lo Gullo R, Marcus E, Huayanay J, et al. Artificial Intelligence-Enhanced Breast MRI: Applications in Breast Cancer Primary Treatment Response Assessment and Prediction. Invest Radiol. 2024;59(3):230–242. doi: 10.1097/RLI.0000000000001010

 

  1. Tiwari A, Mishra S, Kuo TR. Current AI technologies in cancer diagnostics and treatment. Mol Cancer. 2025;24(1):159. doi: 10.1186/s12943-025-02369-9

 

  1. Komura D, Ochi M, Ishikawa S. Machine learning methods for histopathological image analysis: Updates in 2024. Comput Struct Biotechnol J. 2025;27:383–400. doi: 10.1016/j.csbj.2024.12.033

 

  1. Hunter B, Hindocha S, Lee RW. The Role of Artificial Intelligence in Early Cancer Diagnosis. Cancers. 2022;14(6):1524. doi: 10.3390/cancers14061524

 

  1. Kumar Y, Shrivastav S, Garg K, et al. Automating cancer diagnosis using advanced deep learning techniques for multi-cancer image classification. Sci Rep. 2024;14:25006. doi: 10.1038/s41598-024-75876-2

 

  1. Kukla P, Maciejewska K, Strojna I, Zapał M, Zwierzchowski G, Bąk B. Extended Reality in Diagnostic Imaging-A Literature Review. Tomography. 2023;9(3):1071–1082. doi: 10.3390/tomography9030088

 

  1. Tharmaseelan H, Hertel A, Rennebaum S, et al. The Potential and Emerging Role of Quantitative Imaging Biomarkers for Cancer Characterization. Cancers. 2022;14(14):3349. doi: 10.3390/cancers14143349

 

  1. Li Y, Dou Y, Da Veiga Leprevost F, et al. Proteogenomic data and resources for pan-cancer analysis. Cancer Cell. 2023;41(8):1397–1406. doi: 10.1016/j.ccell.2023.06.009

 

  1. Heo YJ, Hwa C, Lee GH, Park JM, An JY. Integrative Multi- Omics Approaches in Cancer Research: From Biological Networks to Clinical Subtypes. Mol Cells. 2021;44(7):433– 443. doi: 10.14348/molcells.2021.0042

 

  1. Boehm KM, Khosravi P, Vanguri R, Gao J, Shah SP. Harnessing multimodal data integration to advance precision oncology. Nat Rev Cancer. 2022;22(2):114–126. doi: 10.1038/s41568-021-00408-3

 

  1. Alkhalaf S, Alturise F, Bahaddad AA, et al. Adaptive Aquila Optimizer with Explainable Artificial Intelligence- Enabled Cancer Diagnosis on Medical Imaging. Cancers. 2023;15(5):1492. doi: 10.3390/cancers15051492

 

  1. Smiley A, Reategui-Rivera CM, Villarreal-Zegarra D, Escobar-Agreda S, Finkelstein J. Exploring Artificial Intelligence Biases in Predictive Models for Cancer Diagnosis. Cancers. 2025;17(3):407. doi: 10.3390/cancers17030407

 

  1. Talaat FM, Gamel SA, El-Balka RM, Shehata M, ZainEldin H. Grad-CAM Enabled Breast Cancer Classification with a 3D Inception-ResNet V2: Empowering Radiologists with Explainable Insights. Cancers. 2024;16(21):3668. doi: 10.3390/cancers16213668

 

  1. Bai S, Nasir S, Khan RA, Meyer A, Konik H. Breast Cancer Diagnosis With Explainable Artificial Intelligence (XAI): Uncovering Strengths and Biases. IEEE Access. 2025;13:205197-205223. doi: 10.1109/access.2025.3639184

 

  1. Amann J, Blasimme A, Vayena E, Frey D, Madai VI, Precise4Q consortium. Explainability for artificial intelligence in healthcare: a multidisciplinary perspective. BMC Med Inf Decis Mak. 2020;20:310. doi: 10.1186/s12911-020-01332-6

 

  1. van Ineveld RL, van Vliet EJ, Wehrens EJ, Alieva M, Rios AC. 3D imaging for driving cancer discovery. EMBO J. 2022;41(10):e109675. doi: 10.15252/embj.2021109675

 

  1. Kobe A, Puippe G, Klotz E, Alkadhi H, Pfammatter T. Computed Tomography for 4-Dimensional Angiography and Perfusion Imaging of the Prostate for Embolization Planning of Benign Prostatic Hyperplasia. Invest Radiol. 2019;54(10):661–668. doi: 10.1097/RLI.0000000000000582

 

  1. Pallumeera M, Giang JC, Singh R, Pracha NS, Makary MS. Evolving and Novel Applications of Artificial Intelligence in Cancer Imaging. Cancers. 2025; 17(9):1510. doi: 10.3390/cancers17091510

 

  1. Cabral BP, Braga LAM, Syed-Abdul S, Mota FB. Future of Artificial Intelligence Applications in Cancer Care: A Global Cross-Sectional Survey of Researchers. Curr Oncol. 2023;30(3):3432–3446. doi: 10.3390/curroncol30030260

 

  1. Capobianco E. High-dimensional role of AI and machine learning in cancer research. Br J Cancer. 2022;126(4):523– 532. doi: 10.1038/s41416-021-01689-z

 

  1. Goel I, Bhaskar Y, Kumar N, et al. Role of AI in empowering and redefining the oncology care landscape: perspective from a developing nation. Front Digit Health. 2025;7:1550407. doi: 10.3389/fdgth.2025.1550407

 

  1. Chapman S, Dobrovolskaia M, Farahani K, et al. Nanoparticles for cancer imaging: The good, the bad, and the promise. Nano Today. 2013;8(5):454–460. doi: 10.1016/j.nantod.2013.06.001

 

  1. Zhang GM, Nie SC, Xu ZY, et al. Advanced Polymeric Nanoagents for Oral Cancer Theranostics: A Mini Review. Front Chem. 2022;10:927595. doi: 10.3389/fchem.2022.927595

 

  1. Soltani M, Moradi Kashkooli F, Souri M, et al. Enhancing Clinical Translation of Cancer Using Nanoinformatics. Cancers. 2021;13(10):2481. doi: 10.3390/cancers13102481

 

  1. Farasati Far B. Artificial intelligence ethics in precision oncology: balancing advancements in technology with patient privacy and autonomy. Explor Target Antitumor Ther. 2023;4:685–689. doi: 10.37349/etat.2023.00160

 

  1. Ziller A, Mueller TT, Stieger S, et al. Reconciling privacy and accuracy in AI for medical imaging. Nat Mach Intell. 2024;6(7):764–774. doi: 10.1038/s42256-024-00858-y

 

  1. Hantel A, Clancy DD, Kehl KL, Marron JM, Van Allen EM, Abel GA. A Process Framework for Ethically Deploying Artificial Intelligence in Oncology. J Clin Oncol. 2022;40(34):3907–3911. doi: 10.1200/JCO.22.01113

 

  1. Urban T, Ziegler E, Lewis R, et al. LesionTracker: Extensible Open-Source Zero-Footprint Web Viewer for Cancer Imaging Research and Clinical Trials. Cancer Res. 2017;77(21):e119–e122. doi: 10.1158/0008-5472.CAN-17-0334

 

  1. Gouda W, Sama NU, Al-Waakid G, Humayun M, Jhanjhi NZ. Detection of Skin Cancer Based on Skin Lesion Images Using Deep Learning. Healthcare. 2022;10(7):1183. doi: 10.3390/healthcare10071183

 

  1. Rao PMM, Singh SK, Khamparia A, Bhushan B, Podder P. Multi-Class Breast Cancer Classification Using Ensemble of Pretrained models and Transfer Learning. Curr Med Imaging. 2022;18(4):409–416. doi: 10.2174/1573405617666210218101418

 

  1. Adams SJ, Mikhael P, Wohlwend J, Barzilay R, Sequist L V, Fintelmann FJ. Artificial Intelligence and Machine Learning in Lung Cancer Screening. Thorac Surg Clin. 2023;33(4):401– 409. doi: 10.1016/j.thorsurg.2023.03.001

 

  1. Shapey J, Kujawa A, Dorent R, et al. Segmentation of vestibular schwannoma from MRI, an open annotated dataset and baseline algorithm. Sci Data. 2021;8:286. doi: 10.1038/s41597-021-01064-w

 

  1. Caban JJ, Joshi A, Nagy P. Rapid development of medical imaging tools with open-source libraries. J Digit Imaging. 2007;20(S1):83–93. doi: 10.1007/s10278-007-9062-3

 

  1. Yoo TS, Ackerman MJ, Lorensen WE, et al. Engineering and algorithm design for an image processing Api: a technical report on ITK - the Insight Toolkit. Stud Health Technol Inform. 2002;85:586–592. doi: 10.3233/978-1-60750-929-5-586

 

  1. Wolf I, Vetter M, Wegner I, et al. The medical imaging interaction toolkit. Med Image Anal. 2005;9(6):594–604. doi: 10.1016/j.media.2005.04.005

 

  1. Ziegler E, Urban T, Brown D, et al. Open Health Imaging Foundation Viewer: An Extensible Open-Source Framework for Building Web-Based Imaging Applications to Support Cancer Research. JCO Clin Cancer Inform. 2020;4:336–345. doi: 10.1200/CCI.19.00131

 

  1. Heudel P-E, Crochet H, Blay J-Y. Impact of artificial intelligence in transforming the doctor–cancer patient relationship. ESMO Real World Data Digit Oncol. 2024;3:100026. doi: 10.1016/j.esmorw.2024.100026

 

  1. Elhaddad M, Hamam S. AI-Driven Clinical Decision Support Systems: An Ongoing Pursuit of Potential. Cureus. .2024;16:e57728. doi: 10.7759/cureus.57728

 

  1. Kong X, Fang H, Chen W, Xiao J, Zhang M. Examining human–AI collaboration in hybrid intelligence learning environments: insight from the Synergy Degree Model. Humanit Soc Sci Commun. 2025;12:821. doi: 10.1057/s41599-025-05097-z

 

  1. Ziegelmayer S, Graf M, Makowski M, Gawlitza J, Gassert F. Cost-Effectiveness of Artificial Intelligence Support in Computed Tomography-Based Lung Cancer Screening. Cancers. 2022;14(7):1729. doi: 10.3390/cancers14071729

 

  1. Nashirudeen Mumuni A, Hasford F, Iniobong Udeme N, Oluwaseun Dada M, Omotayo Awojoyogbe B. 3 A SWOT analysis of artificial intelligence in diagnostic imaging in the developing world: making a case for a paradigm shift. In: Ramasami P, ed. Basic Sciences for Sustainable Development: Energy, Artificial Intelligence, Chemistry, and Materials Science. Berlin Germany: De Gruyter; 2023:pp. 51–84. doi: 10.1515/9783110913361-003

 

  1. Pal A, Shukla KK, Moqurrab SA, Amanzholova S, Rai HM. Transformative impacts of AI and the IoT on healthcare delivery. Eng Rev. 2024;44(3):116–137. doi: 10.30765/er.2523

 

  1. Katirai A. The ethics of advancing artificial intelligence in healthcare: analyzing ethical considerations for Japan’s innovative AI hospital system. Front Public Health. 2023;11:1142062. doi: 10.3389/fpubh.2023.1142062

 

  1. Dave M, Patel N. Artificial intelligence in healthcare and education. Br Dent J. 2023;234(10):761–764. doi: 10.1038/s41415-023-5845-2

 

  1. Zhang J, Duan F, Liu Y, Nie L. High-Resolution Photoacoustic Tomography for Early-Stage Cancer Detection and Its Clinical Translation. Radiol Imaging Cancer. 2020;2(3):e190030. doi: 10.1148/rycan.2020190030

 

  1. Agrawal S, Suresh T, Garikipati A, Dangi A, Kothapalli S-R. Modeling combined ultrasound and photoacoustic imaging: Simulations aiding device development and artificial intelligence. Photoacoustics. 2021;24:100304. doi: 10.1016/j.pacs.2021.100304

 

  1. Carson T, Ghoshal G, Cornwall GB, Tobias R, Schwartz DG, Foley KT. Artificial Intelligence-enabled, Real-time Intraoperative Ultrasound Imaging of Neural Structures Within the Psoas: Validation in a Porcine Spine Model. Spine. 2021;46(3):E146–E152. doi: 10.1097/BRS.0000000000003704

 

  1. Pinto-Coelho L. How Artificial Intelligence Is Shaping Medical Imaging Technology: A Survey of Innovations and Applications. Bioengineering. 2023;10(12):1435. doi: 10.3390/bioengineering10121435

 

  1. Cheung HMC, Rubin D. Challenges and opportunities for artificial intelligence in oncological imaging. Clin Radiol. 2021;76(10):728–736. doi: 10.1016/j.crad.2021.03.009

 

  1. Xu C, Coen-Pirani P, Jiang X. Empirical Study of Overfitting in Deep Learning for Predicting Breast Cancer Metastasis. Cancers. 2023;15(7):1969. doi: 10.3390/cancers15071969

 

  1. Hill DLG. AI in imaging: the regulatory landscape. Br J Radiol. 2024;97(1155):483–491. doi: 10.1093/bjr/tqae002

 

  1. Ahn JS, Shin S, Yang SA, et al. Artificial Intelligence in Breast Cancer Diagnosis and Personalized Medicine. J Breast Cancer. 2023;26(5):405–435. doi: 10.4048/jbc.2023.26.e45

 

  1. Xiang Q, Li D, Hu Z, et al. Quantum classical hybrid convolutional neural networks for breast cancer diagnosis. Sci Rep. 2024;14:24699. doi: 10.1038/s41598-024-74778-7

 

  1. Liao J, Li X, Gan Y, et al. Artificial intelligence assists precision medicine in cancer treatment. Front Oncol. 2023;12:998222. doi: 10.3389/fonc.2022.998222

 

  1. Sah AK, Afzal M, Elshaikh RH, et al. Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes. Life. 2025;15(5):779. doi: 10.3390/life15050779

 

  1. Agrawal S, Vagha S. A Comprehensive Review of Artificial Intelligence in Prostate Cancer Care: State-of-the-Art Diagnostic Tools and Future Outlook. Cureus. 2024;16:e66225. doi: 10.7759/cureus.66225
Share
Back to top
Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing