Association Between ABO Blood Group and Hashimoto Thyroiditis

Objectives: Primary hypothyroidism in iodine-replete areas is commonly caused by chronic autoimmune thyroiditis and is typically manifested as Hashimoto thyroiditis (HT). The association between endocrinological diseases and ABO blood group (BG) has been investigated in very few studies. This study was conducted to investigate whether there is a relationship between HT and ABO BG.
Methods: Patients who were followed up in outpatient clinics with a diagnosis of hypothyroidism and who had elevated anti TPO antibodies, decreased T4 and TSH levels above 10 mU/ml were included in the study. Patients who were admitted to the outpatient clinic for any reason, who did not have a diagnosis of HT, and whose BG were checked were included as the control group (CG).
Results: 851 HT patients were included in the study. A total of 155977 individuals included as the CG. HT patients BG 0 group consisted of 317 (37.3%) individuals. HT patients with BG 0 had a higher risk of HT (OR 1.18 1.02-1.35 p=0.023).
Conclusion: BG 0 was detected more frequently in individuals with HT. We can emphasize that BG 0 is more frequent in diseases associated with autoimmunity and connective tissue origin.
1. Chaker L, Razvi S, Bensenor IM, Azizi F, Pearce EN, Peeters RP. Hypothyroidism. Nat Rev Dis Primers. 2022;8(1):30.
2. Merrill SJ, Minucci SB. Thyroid Autoimmunity: An Interplay of Factors. Vitam Horm. 2018;106:129-45.
3. Shahverdi E, Moghaddam M, Talebian A, Abolghasemi H. Distribution of blood groups in the Iranian general population. Immunohematology. 2016;32(4):135-9.
4. Abegaz SB. Human ABO Blood Groups and Their Associations with Different Diseases. Biomed Res Int. 2021;2021:6629060.
5. Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016;8(6):517-35.
6. Collet A, Zawadzki C, Jeanpierre E, Kitel C, Dubucquoi S, Hachulla E, et al. ABO Blood Groups in Systemic Sclerosis: Distribution and Association with This Disease's Characteristics. J Clin Med. 2022;12(1).
7. Klove-Mogensen K, Steffensen R, Masmas TN, Glenthoj A, Haunstrup TM, Ratcliffe P, et al. ABO, secretor, and Lewis carbohydrate histo-blood groups are associated with autoimmune neutropenia of early childhood in Danish patients. Transfusion. 2022;62(8):1636-42.
8. Nik A, Mirfeizi Z, Rezaieyazdi Z, Khodashahi M, Danevash S, Sheikh Andalibi MS, et al. ABO and Rh blood groups in patients with lupus and rheumatoid arthritis. Caspian J Intern Med. 2021;12(4):568-72.
9. Toft AD, Blackwell CC, Saadi AT, Wu P, Lymberi P, Soudjidelli M, et al. Secretor status and infection in patients with Graves' disease. Autoimmunity. 1990;7(4):279-89.
10. Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, et al. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. Nat Commun. 2018;9(1):4455.
11. Cildag S, Kara Y, Senturk T. ABO blood groups and rheumatic diseases. Eur J Rheumatol. 2017;4(4):250-3.
12. Mete O, Rotstein L, Asa SL. Controversies in thyroid pathology: thyroid capsule invasion and extrathyroidal extension. Ann Surg Oncol. 2010;17(2):386-91.
13. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49(4):137-49.
14. Bayan K, Tuzun Y, Yilmaz S, Dursun M, Canoruc F. Clarifying the relationship between ABO/Rhesus blood group antigens and upper gastrointestinal bleeding. Dig Dis Sci. 2009;54(5):1029- 34.
15. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol. 2010;172(11):1280-5.
16. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 2009;41(9):986-90.
17. Xie J, Qureshi AA, Li Y, Han J. ABO blood group and incidence of skin cancer. PLoS One. 2010;5(8):e11972.
18. Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. Eur J Cancer. 2010;46(18):3345- 50.