Predictive Factors of Post-Void Residual Urine in Patients with Lower Urinary Tract Symptoms
Objectives: Benign prostatic hyperplasia is considered one of the most important health issues seen in older males, and is characterized by clinical lower urinary tract symptoms (LUTS). A high volume of residual urine can be seen in both organic obstructions as well as bladder dysfunctions. In this study, the primary objective was to evaluate clinical and lab results that can be used as predictive factors in significantly high residual urine volume/urinary retention.
Methods: A total of 491 patients over the age of 40 years who presented at the urology clinic with LUTS complaints from September 2015 to December 2016 were included in the study. Our routine evaluation protocol, which consists of patient history, physical examination, prostate-specific antigen test, urinalysis, uroflowmetry, and post-void residual volume assessment, was used to evaluate all the patients included in the study.
Results: In univariate analysis, body mass index, peak flow rate (Qmax), and prostate volume were found to be significant predictive factors of post void residual (PVR) urine (p=0.001, <0.0001, and <0.001, respectively). Multivariate analysis also confirmed these as significant predictive factors of PVR (p=0.013, <0.0001, and 0.001, respectively). Conclusion: Uroflowmetry is a very important tool in the assessment and follow-up of patients with LUTS. As a complementary action, PVR urine volume should also be measured. Residual urine can be significant in patients Qmax of less than 10.1 mL/second and with large prostate volume (>40 cc).
1.Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol 1984;132:474–9. [CrossRef]
2. Rosen R, Altwein J, Boyle P, Kirby RS, Lukacs B, Meuleman E, et al. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol 2003;44:637–49. [CrossRef]
3. Gallien P, Reymann JM, Amarenco G, Nicolas B, de Sèze M, Bellissant E. Placebo controlled, randomised, double blind study of the effects of botulinum A toxin on detrusor sphincter dyssynergia in multiple sclerosis patients. J Neurol Neurosurg Psychiatry 2005;76:1670–6. [CrossRef]
4. Bøtker-Rasmussen I, Bagi P, Jørgensen JB. Is bladder outlet obstruction normal in elderly men without lower urinary tract symptoms? Neurourol Urodyn 1999;18:545–51; discussion 551–2. [CrossRef]
5. Ghalayini IF, Al-Ghazo MA, Pickard RS. A prospective randomized trial comparing transurethral prostatic resection and clean intermittent self-catheterization in men with chronic urinary retention. BJU Int 2005;96:93–7. [CrossRef]
6. Belal M, Abrams P. Noninvasive methods of diagnosing bladder outlet obstruction in men. Part 1: Nonurodynamic approach. J Urol 2006;176:22–8. [CrossRef]
7. Beekman M, Merrick GS, Butler WM, Wallner KE, Allen ZA, Galbreath RW. Selecting patients with pretreatment postvoid residual urine volume less than 100 mL may favorably influence brachytherapy-related urinary morbidity. Urology 2005;66:1266–70. [CrossRef]
8. Managadze M, Tchanturaia Z. Trabeculation of urinary bladder by ultrasound in patients with benign prostatic hyperplasia. Georgian Med News 2006;16–8.
9. Grossfeld GD, Coakley FV. Benign prostatic hyperplasia: clinical overview and value of diagnostic imaging. Radiol Clin North Am 2000;38:31–47. [CrossRef]
10. Chia SJ, Heng CT, Chan SP, Foo KT. Correlation of intravesical prostatic protrusion with bladder outlet obstruction. BJU Int 2003;91:371–4. [CrossRef]
11. Kranse R, van Mastrigt R. Weak correlation between bladder outlet obstruction and probability to void to completion. Urology 2003;62:667–71. [CrossRef]
12. Turner-Warwick R, Whiteside CG, Worth PH, Milroy EJ, Bates CP. A urodynamic view of the clinical problems associated with bladder neck dysfunction and its treatment by endoscopic incision and trans-trigonal posterior prostatectomy. Br J Urol 1973;45:44–59. [CrossRef]
13. Neal DE, Ramsden PD, Sharples L, Smith A, Powell PH, Styles RA, et al. Outcome of elective prostatectomy. BMJ 1989;299:762– 7. [CrossRef]
14. Cornud F, Belin X, Piron D, Chrétien Y, Flam T, Casanova JM,et al. Color Doppler-guided prostate biopsies in 591 patients with an elevated serum PSA level: impact on Gleason score for nonpalpable lesions. Urology 1997;49:709–15. [CrossRef]
15. Rifkin MD, Sudakoff GS, Alexander AA. Prostate: techniques, results, and potential applications of color Doppler US scanning. Radiology 1993;186:509–13. [CrossRef]
16. Hayami S, Ushiyama T, Kurita Y, Kageyama S, Suzuki K, Fujita K. The value of power Doppler imaging to predict the histologic components of benign prostatic hyperplasia. Prostate 2002;53:168–74. [CrossRef]
17. Clautice-Engle T, Jeffrey RB Jr, Li KC, Barth RA. Power Doppler imaging of focal lesions of the gastrointestinal tract: comparison with conventional color Doppler imaging. J Ultrasound Med 1996;15:63–6. [CrossRef]
18. Klarskov P, Andersen JT, Asmussen CF, Brenøe J, Jensen SK, Jensen IL, et al. Symptoms and signs predictive of the voiding pattern after acute urinary retention in men. Scand J Urol Nephrol 1987;21:23–8. [CrossRef]
19. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al; Standards for Reporting of Diagnostic Accuracy. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ 2003;326:41–4.
20. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 2003;139:161–8. [CrossRef]
