Hereditary Breast Cancer

¹ Center for Medical and Biotechnological Research of the University of Carabobo, Faculty of Health Sciences, University of Carabobo, Valencia, Venezuela

² Department of Physiological Sciences, School of Biomedical and Technological Sciences, Faculty of Health Sciences, University of Carabobo, Valencia, Venezuela

CP 2020, 2(1), 21–29; https://doi.org/10.18063/cp.v2i1.341

Received: 20 November 2019 | Accepted: 24 February 2019 | Published online: 18 March 2019

© 2019 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Breast cancer occurs when breast cells grow out of control because they escape the fine controls that regulate cell multiplication, resulting in cell proliferation unresponsive to regulation. Most cases of breast cancer have no identifiable cause, but approximately 5% to 10% are caused by inherited genetic mutations. Although other genes are known to cause hereditary breast cancer, most studies evaluating clinical management strategies have focused on women with mutations in the BRCA1 or BRCA2 (Breast Cancer) genes. People with these mutations have a significantly increased lifetime risk of cancer compared to the general population.

Keywords

Breast cancer

Hereditary mutations

BRCA1 gene

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